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Year 2010, Volume: 23 Issue: 3, 339 - 346, 28.04.2015

Abstract

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References

  • 1. Van Leerdam ME, Tygat GN. Review article: Halicobacter pylori infection in peptic ulcer hemorrhage. Aliment Pharmacol Ther 2002;16 (suppl 1):66-78.
  • 2. Vreeburg EM, Snel P, de Bruijne JW, Bartelsman JF, Rauws EA, Tytgat GN. Acute upper gastrointestinal bleeding in the Amsterdam area: incidence, diagnosis and clinical outcome. Am J Gastroenterol 1997;92:236- 43.
  • 3. Brullet E, Campo R, Calvet X, Coroleu D, Rivero E, Simo Deu J. Factors related to the failure of endoscopic injection therapy for bleeding gastric ulcer. Gut 1996;39:155-8.
  • 4. Blatchford O, Davidson LA, Murray WR, Blatchford M, Pell J. Acute upper gastrointestinal haemorrhage in west of Scotland: case ascertainment study. BMJ 1997;315:510-4.
  • 5. Marmo R, Koch M, Cipolletta L, et al. Predictive factors of mortality from nonvariceal upper gastrointestinal hemorrhage: a multicenter study. Am J Gastroenterol 2008;103:1639-47
  • 6. Laine L, Peterson WL. Bleeding peptic ulcer. N Engl J Med 1994;331:717-27.
  • 7. Cohen M, Sapoznikov B, Niv Y. Primary and secondary nonvariceal upper gastrointestinal bleeding. J Clin Gastroenterol 2007;41:810-3
  • 8. Laine L. Gastrointestinal bleeding. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, eds. Harrision's Principles of Internal Medicine. 17 th ed. New York: McGraw-Hill Companies, 2008:257-60
  • 9. Pilotto A, Ferrucci L, Scarcelli C, et al. Usefulness of the comprehensive geriatric assesment in older patients with upper gastrointestinal bleeding: a two-year followup study. Dig Dis 2007;25:124-8.
  • 10. Marshall JK, Collins SM, Gafni A. Prediction of resource utilization and case cost for acute nonvariceal upper gastrointestinal hemorrhage at a Canadian community hospital. Am J Gastroenterol 1999;94:1841-6.
  • 11. Ong TZ, Hawkey CJ, Ho KY. Nonsteroidal antiinflammatory drug use is a significant cause of peptic ulcer disease in a tertiary hospital in Singapore: a prospective study. J Clin Gastroenterol 2006;40:795- 800.
  • 12. Vreeburg EM, de Bruijne HW, Snel P, Bartelsman JW, Rauws EA, Tytgat GN. Previous use of non-steroidal anti-inflammatory drugs and anticoagulants: the influence on clinical outcome of bleeding gastroduodenal ulcers. Eur J Gastroenterol Hepatol 1997;9:41-4.
  • 13. Thomopoulos KC, Vagenas KA, Vagianos CE, et al. Changes in etiology and clinical outcome of acute upper gastrointestinal bleeding during the last 15 years. Eur J Gastroenterol Hepatol 2004;16:177-82.
  • 14. Mellemkjaer L, Blot WJ, Sørensen HT, et al. Upper gastrointestinal bleeding among users of NSAIDs: a population-based cohort study in Denmark. Br J Clin Pharmacol 2002;53:173-81.
  • 15. Weil J, Langman MJS, Wainwright P, et al. Peptic ulcer bleeding: accessory risk factors and interactions with non-steroidal anti-inflammatory drugs. Gut 2000;46:27-31.
  • 16. Langman MJ, Weil J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994;343:1075-8.
  • 17. Shorr RI, Ray WA, Daugherty JR, Griffin MR. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993;153:1665-70.
  • 18. Slattery J, Warlow CP, Shorrock CJ, Langman MJ. Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin - analysis of gastrointestinal bleeding during the UK-TIA trial. Gut 1995;37:509-11.
  • 19. Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. The SALT Collaborative Group. Lancet 1991;338:1345-9.
  • 20. Cryer B, Feldman M. Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans. Gastroenterol 1999;117:17-25.
  • 21. Lanas A, Rodrigo L, Marquez JL, et al; EMPHASYS Study Group. Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole. Scand J Gastroenterol 2003;38:693-700.
  • 22. Longstreth GF. Epidemiology of hospitalization for acute upper gastrointestinal hemorrhage: a populationbased study. Am J Gastroenterol 1995;90:206-10.
  • 23. Wong SN, Sollano JD, Chan MM, et al. Changing trends in peptic ulcer prevalence in a tertiary care setting in the Philippines: a seven-year study. J Gastroenterol Hepatol 2005;20:628-32.
  • 24. Yachimski PS, Friedman LS. Gastrointestinal bleeding in the elderly. Nat Clin Pract Gastroenterol Hepatol 2008;5:80-93.
  • 25. Skok P. The epidemiology of hemorrhage from the upper gastrointestinal tract in the mid-nineties--has anything changed? Hepatogastroenterology 1998;45:2228-33.
  • 26. Lanas A, Hirschowitz BI. Toxicity of NSAIDs in the stomach and duodenal. Eur J Gastroenterol Hepatol 1999;11:375-81
  • 27. Sugawa C, Steffes CP, Nakamura R, et al. Upper GI bleeding in an urban hospital. Etiology, recurrence and prognosis. Ann Surg 1990;212:521-6.
  • 28. Segal WN, Cello JP. Hemorrhage in the upper gastrointestinal tract in the older patient. Am J Gastroenterol 1997;92:42-6.
  • 29. Koruk M, Polat G, Balık A, Onuk MD, Yılmaz A. Acute upper gastrointestinal bleeding in the region of Erzurum: frequency, cause and clinical features (abstract). Turkish J Gastroenterol 1999;10 (suppl 2):A123 (Turkish).
  • 30. Osmanoglu S, Bayramicli OU, Kılıc D, Kavaklı B, Yayla A. The evaluation of endoscopic and pathological findings in patients with upper gastrointestinal bleeding (abstract). Turkish J Gastroenterol 1999;10 (suppl 2):A125 (Turkish).
  • 31. Simsek Z, Arslan G, Yoruk O, Yıldırım IS. The evaluation of 161 cases with upper gastrointestinal system bleeding (abstract). Turkish J Gastroenterol 1999;10 (suppl 2):A121 (Turkish).
  • 32. Yalcın B, Zengin N, Aydın, et al. The clinical and pathological features of patients with gastric cancer in Turkey: A Turkish Oncology Group Study. Turk J Cancer 2006;36:108-15.
  • 33. Demirer T, Icli F, Uzunalimoglu O, Kucuk O. Diet and stomach cancer incidence. A case-control study in Turkey. Cancer 2006; 65:2344-48.
  • 34. Yurdaydin C, Krastev Z, Bulajic M, et al. Gastrointestinal tract cancer in Southeastern Europe: a multinational study with the participation of seven countries (abstract). Gut 2002;51 (suppl 3):A263.
  • 35. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev 2000;22:283-97.
  • 36. Ozaydın ANG, Calı S, Turkyılmaz AS, Hancıoglu A. TURHEP: Turkey Helicobacter Pilory Prevalence Survey 2003. ISBN 978975923434-8, Istanbul 2007.
  • 37. Yuan Y, Wang C, Hunt RH. Endoscopic clipping for acute nonvariceal upper-GI bleeding: a meta-analysis and critical appraisal of randomized controlled trials. Gastrointest Endosc 2008;68:339-51.
  • 38. Longstreth GF, Feitelberg SP. Hospital care of acute nonvariceal upper gastrointestinal bleeding:1991 versus 1981. J Clin Gastroenterol 1994;19:189-93.
  • 39. Blocksom JM, Tokioka S, Sugawa C. Current therapy for nonvariceal upper gastrointestinal bleeding. Surg Endosc 2004;18:186-92.

MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ

Year 2010, Volume: 23 Issue: 3, 339 - 346, 28.04.2015

Abstract

Amaç: Endoskopik tedavi çağında, varis dışı üst gastrointestinal kanama hala önemli bir mortalite ve morbidite nedenidir. Bu çalışmanın amacı, bir eğitim hastanesine varis dışı üst gastrointestinal kanamayla başvuran hastaları klinik ve endoskopik özellikleri açısından araştırmaktır. Metod: Varis dışı üst gastrointestinal kanamayla 1996-2001 tarihleri arasında başvuran 250 hasta retrospektif olarak incelendi. Bulgular: Hastaların ortalama yaşı 59 olup %34.4'ü kadındı. Hastaların %59.6'sında aspirin/non-steroidal anti-inflamatuar ilaç (NSAİİ), %2.8'inde steroid ve %9.6'sınde varfarin kullanımı vardı. Vakaların %31.8'i daha önce de gastrointestinal sistem kanaması geçirmişti. En sık görülen lezyon peptik ülserdi (%49.2), bunu duodenal ve gastrik erozyonlar (%19.2) ile mide tümörleri (%10.8) izliyordu. Lezyonlar mide (%40), duodenum (%33.6), gastrojejunal bileşke (%4.4) ve özofagus (%4.4) yerleşimliydi. H. pylori varlığı 48 olguda araştırıldı, bunların %79.2'sinde pozitif bulundu. Aktif kanama belirtisi olan 33 hastaya endoskopik tedavi uygulandı. Endoskopik tedavisi başarısız olan 3 hastayla beraber 7 hastaya (%2.8) cerrahi işlem uygulandı. Hastaların 6'sı (%2.4) kaybedildi. Sonuç: Çalışmamızda en önemli kanama nedeni peptik ülserdi. Hastaların büyük bir çoğunluğunda kanamaya neden olacak en az bir risk faktörü vardı (H. pilori veya ilaç kullanımı). Kanama nedenleri kolay tedavi edilebildiğinden, hasta grubumuzda endoskopik ve cerrahi tedavi oranı ile mortalite düşük bulundu.

Anahtar Kelimeler: NSAİİ, aspirin, endoskopik tedavi, morbidite ve mortalite

References

  • 1. Van Leerdam ME, Tygat GN. Review article: Halicobacter pylori infection in peptic ulcer hemorrhage. Aliment Pharmacol Ther 2002;16 (suppl 1):66-78.
  • 2. Vreeburg EM, Snel P, de Bruijne JW, Bartelsman JF, Rauws EA, Tytgat GN. Acute upper gastrointestinal bleeding in the Amsterdam area: incidence, diagnosis and clinical outcome. Am J Gastroenterol 1997;92:236- 43.
  • 3. Brullet E, Campo R, Calvet X, Coroleu D, Rivero E, Simo Deu J. Factors related to the failure of endoscopic injection therapy for bleeding gastric ulcer. Gut 1996;39:155-8.
  • 4. Blatchford O, Davidson LA, Murray WR, Blatchford M, Pell J. Acute upper gastrointestinal haemorrhage in west of Scotland: case ascertainment study. BMJ 1997;315:510-4.
  • 5. Marmo R, Koch M, Cipolletta L, et al. Predictive factors of mortality from nonvariceal upper gastrointestinal hemorrhage: a multicenter study. Am J Gastroenterol 2008;103:1639-47
  • 6. Laine L, Peterson WL. Bleeding peptic ulcer. N Engl J Med 1994;331:717-27.
  • 7. Cohen M, Sapoznikov B, Niv Y. Primary and secondary nonvariceal upper gastrointestinal bleeding. J Clin Gastroenterol 2007;41:810-3
  • 8. Laine L. Gastrointestinal bleeding. In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, eds. Harrision's Principles of Internal Medicine. 17 th ed. New York: McGraw-Hill Companies, 2008:257-60
  • 9. Pilotto A, Ferrucci L, Scarcelli C, et al. Usefulness of the comprehensive geriatric assesment in older patients with upper gastrointestinal bleeding: a two-year followup study. Dig Dis 2007;25:124-8.
  • 10. Marshall JK, Collins SM, Gafni A. Prediction of resource utilization and case cost for acute nonvariceal upper gastrointestinal hemorrhage at a Canadian community hospital. Am J Gastroenterol 1999;94:1841-6.
  • 11. Ong TZ, Hawkey CJ, Ho KY. Nonsteroidal antiinflammatory drug use is a significant cause of peptic ulcer disease in a tertiary hospital in Singapore: a prospective study. J Clin Gastroenterol 2006;40:795- 800.
  • 12. Vreeburg EM, de Bruijne HW, Snel P, Bartelsman JW, Rauws EA, Tytgat GN. Previous use of non-steroidal anti-inflammatory drugs and anticoagulants: the influence on clinical outcome of bleeding gastroduodenal ulcers. Eur J Gastroenterol Hepatol 1997;9:41-4.
  • 13. Thomopoulos KC, Vagenas KA, Vagianos CE, et al. Changes in etiology and clinical outcome of acute upper gastrointestinal bleeding during the last 15 years. Eur J Gastroenterol Hepatol 2004;16:177-82.
  • 14. Mellemkjaer L, Blot WJ, Sørensen HT, et al. Upper gastrointestinal bleeding among users of NSAIDs: a population-based cohort study in Denmark. Br J Clin Pharmacol 2002;53:173-81.
  • 15. Weil J, Langman MJS, Wainwright P, et al. Peptic ulcer bleeding: accessory risk factors and interactions with non-steroidal anti-inflammatory drugs. Gut 2000;46:27-31.
  • 16. Langman MJ, Weil J, Wainwright P, et al. Risks of bleeding peptic ulcer associated with individual nonsteroidal anti-inflammatory drugs. Lancet 1994;343:1075-8.
  • 17. Shorr RI, Ray WA, Daugherty JR, Griffin MR. Concurrent use of nonsteroidal anti-inflammatory drugs and oral anticoagulants places elderly persons at high risk for hemorrhagic peptic ulcer disease. Arch Intern Med 1993;153:1665-70.
  • 18. Slattery J, Warlow CP, Shorrock CJ, Langman MJ. Risks of gastrointestinal bleeding during secondary prevention of vascular events with aspirin - analysis of gastrointestinal bleeding during the UK-TIA trial. Gut 1995;37:509-11.
  • 19. Swedish Aspirin Low-Dose Trial (SALT) of 75 mg aspirin as secondary prophylaxis after cerebrovascular ischaemic events. The SALT Collaborative Group. Lancet 1991;338:1345-9.
  • 20. Cryer B, Feldman M. Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans. Gastroenterol 1999;117:17-25.
  • 21. Lanas A, Rodrigo L, Marquez JL, et al; EMPHASYS Study Group. Low frequency of upper gastrointestinal complications in a cohort of high-risk patients taking low-dose aspirin or NSAIDS and omeprazole. Scand J Gastroenterol 2003;38:693-700.
  • 22. Longstreth GF. Epidemiology of hospitalization for acute upper gastrointestinal hemorrhage: a populationbased study. Am J Gastroenterol 1995;90:206-10.
  • 23. Wong SN, Sollano JD, Chan MM, et al. Changing trends in peptic ulcer prevalence in a tertiary care setting in the Philippines: a seven-year study. J Gastroenterol Hepatol 2005;20:628-32.
  • 24. Yachimski PS, Friedman LS. Gastrointestinal bleeding in the elderly. Nat Clin Pract Gastroenterol Hepatol 2008;5:80-93.
  • 25. Skok P. The epidemiology of hemorrhage from the upper gastrointestinal tract in the mid-nineties--has anything changed? Hepatogastroenterology 1998;45:2228-33.
  • 26. Lanas A, Hirschowitz BI. Toxicity of NSAIDs in the stomach and duodenal. Eur J Gastroenterol Hepatol 1999;11:375-81
  • 27. Sugawa C, Steffes CP, Nakamura R, et al. Upper GI bleeding in an urban hospital. Etiology, recurrence and prognosis. Ann Surg 1990;212:521-6.
  • 28. Segal WN, Cello JP. Hemorrhage in the upper gastrointestinal tract in the older patient. Am J Gastroenterol 1997;92:42-6.
  • 29. Koruk M, Polat G, Balık A, Onuk MD, Yılmaz A. Acute upper gastrointestinal bleeding in the region of Erzurum: frequency, cause and clinical features (abstract). Turkish J Gastroenterol 1999;10 (suppl 2):A123 (Turkish).
  • 30. Osmanoglu S, Bayramicli OU, Kılıc D, Kavaklı B, Yayla A. The evaluation of endoscopic and pathological findings in patients with upper gastrointestinal bleeding (abstract). Turkish J Gastroenterol 1999;10 (suppl 2):A125 (Turkish).
  • 31. Simsek Z, Arslan G, Yoruk O, Yıldırım IS. The evaluation of 161 cases with upper gastrointestinal system bleeding (abstract). Turkish J Gastroenterol 1999;10 (suppl 2):A121 (Turkish).
  • 32. Yalcın B, Zengin N, Aydın, et al. The clinical and pathological features of patients with gastric cancer in Turkey: A Turkish Oncology Group Study. Turk J Cancer 2006;36:108-15.
  • 33. Demirer T, Icli F, Uzunalimoglu O, Kucuk O. Diet and stomach cancer incidence. A case-control study in Turkey. Cancer 2006; 65:2344-48.
  • 34. Yurdaydin C, Krastev Z, Bulajic M, et al. Gastrointestinal tract cancer in Southeastern Europe: a multinational study with the participation of seven countries (abstract). Gut 2002;51 (suppl 3):A263.
  • 35. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev 2000;22:283-97.
  • 36. Ozaydın ANG, Calı S, Turkyılmaz AS, Hancıoglu A. TURHEP: Turkey Helicobacter Pilory Prevalence Survey 2003. ISBN 978975923434-8, Istanbul 2007.
  • 37. Yuan Y, Wang C, Hunt RH. Endoscopic clipping for acute nonvariceal upper-GI bleeding: a meta-analysis and critical appraisal of randomized controlled trials. Gastrointest Endosc 2008;68:339-51.
  • 38. Longstreth GF, Feitelberg SP. Hospital care of acute nonvariceal upper gastrointestinal bleeding:1991 versus 1981. J Clin Gastroenterol 1994;19:189-93.
  • 39. Blocksom JM, Tokioka S, Sugawa C. Current therapy for nonvariceal upper gastrointestinal bleeding. Surg Endosc 2004;18:186-92.
There are 39 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Türkay Akbaş

Neşe İmeryüz This is me

Aysun Bozbaş This is me

Nurdan Tözün This is me

Publication Date April 28, 2015
Published in Issue Year 2010 Volume: 23 Issue: 3

Cite

APA Akbaş, T., İmeryüz, N., Bozbaş, A., Tözün, N. (2015). MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ. Marmara Medical Journal, 23(3), 339-346.
AMA Akbaş T, İmeryüz N, Bozbaş A, Tözün N. MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ. Marmara Med J. August 2015;23(3):339-346.
Chicago Akbaş, Türkay, Neşe İmeryüz, Aysun Bozbaş, and Nurdan Tözün. “MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ”. Marmara Medical Journal 23, no. 3 (August 2015): 339-46.
EndNote Akbaş T, İmeryüz N, Bozbaş A, Tözün N (August 1, 2015) MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ. Marmara Medical Journal 23 3 339–346.
IEEE T. Akbaş, N. İmeryüz, A. Bozbaş, and N. Tözün, “MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ”, Marmara Med J, vol. 23, no. 3, pp. 339–346, 2015.
ISNAD Akbaş, Türkay et al. “MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ”. Marmara Medical Journal 23/3 (August 2015), 339-346.
JAMA Akbaş T, İmeryüz N, Bozbaş A, Tözün N. MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ. Marmara Med J. 2015;23:339–346.
MLA Akbaş, Türkay et al. “MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ”. Marmara Medical Journal, vol. 23, no. 3, 2015, pp. 339-46.
Vancouver Akbaş T, İmeryüz N, Bozbaş A, Tözün N. MARMARA ÜNİVERSİTESİ HASTANESİNE VARİS DIŞI ÜST GASTROİNTESTİNAL KANAMA İLE BAŞVURAN HASTALARIN DEĞERLENDİRİLMESİ. Marmara Med J. 2015;23(3):339-46.