Objective: This study explores the correlation between the expression of E-cadherin, p53 tumor suppressor gene, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases.
Patients and Methods: We have investigated tumor samples from sixty patients with invasive ductal breast carcinoma. 30 of the patients had axillary lymph node metastases and 30 had no axillary lymph node metastases. Tumor tissues of these patients were evaluated by immunohistochemistry for E-cadherin, p53, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR).
Results: E-cadherin staining was not expressed in 39 patients (65%) with invasive ductal breast carcinoma. ER, PgR, p53, and c-erb-B2 signals were positive in 36 (60%), 26 (43.3%), 33 (55%), and 29 (48.3%) of the patients, respectively. PgR and c-erb-B2 expression was associated with lymph node metastases (p=0.009, p=0.001, respectively). No association was found between the reduced E-cadherin protein and age. The presence of E-cadherin was associated with axillary lymph node metastases and p53 (p<0.009, p<0.001, respectively).
Conclusion: We found that, the p53 protein may play a role in regulation of E-cadherin protein expression in invasive ductal breast carcinomas with axillary lymph node metastases.
Keywords: Breast carcinoma, E-cadherin, p53, c-erb-B2, ER, PgR, Metastases
Primary Language | en |
---|---|
Journal Section | Articles |
Authors | |
Dates |
Publication Date : September 14, 2015 |
Bibtex | @ { marumj3179,
journal = {Marmara Medical Journal},
issn = {1019-1941},
eissn = {1309-9469},
address = {},
publisher = {Marmara University},
year = {2015},
volume = {28},
pages = {99 - 104},
doi = {10.5472/MMJoa.2802.07},
title = {Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases},
key = {cite},
author = {Kılınç, Nihal}
} |
APA | Kılınç, N . (2015). Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases . Marmara Medical Journal , 28 (2) , 99-104 . DOI: 10.5472/MMJoa.2802.07 |
MLA | Kılınç, N . "Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases" . Marmara Medical Journal 28 (2015 ): 99-104 <https://dergipark.org.tr/en/pub/marumj/issue/430/3179> |
Chicago | Kılınç, N . "Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases". Marmara Medical Journal 28 (2015 ): 99-104 |
RIS | TY - JOUR T1 - Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases AU - Nihal Kılınç Y1 - 2015 PY - 2015 N1 - doi: 10.5472/MMJoa.2802.07 DO - 10.5472/MMJoa.2802.07 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 99 EP - 104 VL - 28 IS - 2 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/MMJoa.2802.07 UR - https://doi.org/10.5472/MMJoa.2802.07 Y2 - 2021 ER - |
EndNote | %0 Marmara Medical Journal Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases %A Nihal Kılınç %T Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases %D 2015 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 28 %N 2 %R doi: 10.5472/MMJoa.2802.07 %U 10.5472/MMJoa.2802.07 |
ISNAD | Kılınç, Nihal . "Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases". Marmara Medical Journal 28 / 2 (September 2015): 99-104 . https://doi.org/10.5472/MMJoa.2802.07 |
AMA | Kılınç N . Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases. Marmara Med J. 2015; 28(2): 99-104. |
Vancouver | Kılınç N . Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases. Marmara Medical Journal. 2015; 28(2): 99-104. |
IEEE | N. Kılınç , "Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases", Marmara Medical Journal, vol. 28, no. 2, pp. 99-104, Sep. 2015, doi:10.5472/MMJoa.2802.07 |