Year 2015, Volume 28 , Issue 2, Pages 99 - 104 2015-09-14

Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases
Aksiller lenf nodu metastazlı invaziv duktal meme karsinomda E-cadherin, p53, c-erb-B2 (HER- 2/neu) ve steroid reseptörleri (ER, PgR) ekspresyonu arasındaki ilişki

Nihal KILINÇ [1]


Objective: This study explores the correlation between the expression of E-cadherin, p53 tumor suppressor gene, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases.

Patients and Methods: We have investigated tumor samples from sixty patients with invasive ductal breast carcinoma. 30 of the patients had axillary lymph node metastases and 30 had no axillary lymph node metastases. Tumor tissues of these patients were evaluated by immunohistochemistry for E-cadherin, p53, c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR). 

Results: E-cadherin staining was not expressed in 39 patients (65%) with invasive ductal breast carcinoma. ER, PgR, p53, and c-erb-B2 signals were positive in 36 (60%), 26 (43.3%), 33 (55%), and 29 (48.3%) of the patients, respectively. PgR and c-erb-B2 expression was associated with lymph node metastases (p=0.009, p=0.001, respectively). No association was found between the reduced E-cadherin protein and age. The presence of E-cadherin was associated with axillary lymph node metastases and p53 (p<0.009, p<0.001, respectively).

Conclusion: We found that, the p53 protein may play a role in regulation of E-cadherin protein expression in invasive ductal breast carcinomas with axillary lymph node metastases.

Keywords: Breast carcinoma, E-cadherin, p53, c-erb-B2, ER, PgR, Metastases

Amaç: Aksiller lenf nodu metastazlı invaziv duktal meme karsinomda E-cadherin, p53 tümör supressör gen, c-erbB-2 (HER2/neu) ve steroid reseptörleri (ER ve PgR) ekspresyonu arasındaki ilişkiyi araştırmak amaçlanmıştır.Hastalar ve Yöntem: Bu çalışmada, 30 aksiller lenf nodu metastazlı ve 30 aksiller lenf nodu metastazı mevcut olmayan invaziv duktal meme karsinomlu 60 hasta immunokimyasal metodu kullanılarak E-cadherin ve c-erbB-2, ER ve PgR antikorları değerlendirildi.Bulgular: İnvaziv duktal meme karsinomlu 60 hastanın 39’unda (%65) E-cadherin ile boyanma tesbit edilmedi. Sırasıyla ER, PgR, p53, ve c-erb-B2, 60 hastanın 36’ında (%60), 60 hastanın 26’ında (%43,3), 60 hastanın 33’ünde (%55), and 60 hastanın 29’unda (%48,3) pozitif boyanma görüldü. PgR ve c-erb-B2 boyanması lenf nodu metastazı ile ilişkili idi (sırasıyla, p=0,009, p=0,001). E-cadherin proteini ile yaş arasında ilişki görülmedi. E-cadherin ile lenf nodu metastazı ve p53 arasında ilişki görüldü (sırasıyla, p
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Primary Language en
Journal Section Articles
Authors

Author: Nihal KILINÇ

Dates

Publication Date : September 14, 2015

Bibtex @ { marumj3179, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara University}, year = {2015}, volume = {28}, pages = {99 - 104}, doi = {10.5472/MMJoa.2802.07}, title = {Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases}, key = {cite}, author = {Kılınç, Nihal} }
APA Kılınç, N . (2015). Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases . Marmara Medical Journal , 28 (2) , 99-104 . DOI: 10.5472/MMJoa.2802.07
MLA Kılınç, N . "Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases" . Marmara Medical Journal 28 (2015 ): 99-104 <https://dergipark.org.tr/en/pub/marumj/issue/430/3179>
Chicago Kılınç, N . "Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases". Marmara Medical Journal 28 (2015 ): 99-104
RIS TY - JOUR T1 - Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases AU - Nihal Kılınç Y1 - 2015 PY - 2015 N1 - doi: 10.5472/MMJoa.2802.07 DO - 10.5472/MMJoa.2802.07 T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 99 EP - 104 VL - 28 IS - 2 SN - 1019-1941-1309-9469 M3 - doi: 10.5472/MMJoa.2802.07 UR - https://doi.org/10.5472/MMJoa.2802.07 Y2 - 2021 ER -
EndNote %0 Marmara Medical Journal Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases %A Nihal Kılınç %T Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases %D 2015 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 28 %N 2 %R doi: 10.5472/MMJoa.2802.07 %U 10.5472/MMJoa.2802.07
ISNAD Kılınç, Nihal . "Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases". Marmara Medical Journal 28 / 2 (September 2015): 99-104 . https://doi.org/10.5472/MMJoa.2802.07
AMA Kılınç N . Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases. Marmara Med J. 2015; 28(2): 99-104.
Vancouver Kılınç N . Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases. Marmara Medical Journal. 2015; 28(2): 99-104.
IEEE N. Kılınç , "Relation between the expression of E-cadherin, p53,c-erb-B2 (HER-2/neu) and steroid receptors (ER, PgR) in invasive ductal breast carcinoma with axillary lymph node metastases", Marmara Medical Journal, vol. 28, no. 2, pp. 99-104, Sep. 2015, doi:10.5472/MMJoa.2802.07