Research Article
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Year 2019, Volume: 32 Issue: 3, 112 - 117, 31.10.2019
https://doi.org/10.5472/marumj.637180

Abstract

References

  • [1] Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM. A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum 2014 ;43:701-12. doi: 10.1016/j.semarthrit.2013.11.012.
  • [2] Bannuru R R, Vaysbrot E E, Sullivan M C, McAlindon T E. Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis: a systematic review and metaanalysis. Semin Arthritis Rheum 2014;43:593-9. doi:10.1016/j. semarthrit.2013.10.002.
  • [3] Sen C, Güneş T, Saygi B, Erdem M, Köseoğlu R D, Kilic N. The chondroprotective effect of intra-articular hyaluronic acid at early stages of osteoarthritis: An experimental study in rabbits. Acta Orthop Traumatol Turc 2004;38:348-52.
  • [4] Özkan ÜF, Özkan K, Ramadan S, Güven Z. Chondroprotective effect of N-acetylglucosamine and hyaluronate in early stages of osteoarthritis an experimental study in rabbits. Bulletin of the NYU Hospital for Joint Diseases 2009; 67:352-7.
  • [5] Orak M. M, Ak D, Midi A, et al. Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. Acta Orthop Traumatol Turc 2015;49:438-46. doi: 10.3944/ AOTT.2015.14.0312.
  • [6] Herrero-Beaumont G, Rovati LC, Castañeda S, Alvarez- Soria MA, Largo R. The reverse glucosamine sulfate pathway: application in knee osteoarthritis. Expert Opin Pharmacother. 2007 Feb;8(2):215-25. DOI: 10.1517/14656566.8.2.215
  • [7] Cen X, Liu Y, Wang S, Yang X, Shi Z, Liang X et al. Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis. Oral Dis. 2018 Apr;24(3):404-411. doi: 10.1111/odi.12760.
  • [8] Torrent A, Montell E, Vergés J, et al. SAT0547 Chondroprotective activity of acti-joint®, a combination of chondroitin sulphate, glucosamine and a natural ıngredient rich in hyaluronic acid. Ann Rheum Dis 2014;73(Suppl 2):789-9. doi: 10.1016/j.joca.2014.02.602
  • [9] Müller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994; 2:61-9.
  • [10] van der Sluijs JA, Geesink RG, van der Linden AJ, Bulstra SK, Kuyer R, Drukker J. The reliability of the Mankin score for osteoarthritis. J Orthop Res 1992, 10:58–61. doi:10.1002/ jor.110.010.0107
  • [11] Heybeli N, Doral M N, Atay O A, Leblebicioglu G, Uzumcugil A. Intra-articular sodium hyaluronate injections after arthroscopic debridement for osteoarthritis of the knee: a prospective, randomized, controlled study. Acta Orthop Traumatol Turc 2008;42:221-7.
  • [12] Şükür E, Talu C, Akman Y E, Çirci E, Öztürkmen Y, Tüzüner T. Comparison of the chondroprotective effect of a novel hydrogel compound and traditional hyaluronate on rat cartilage in a papain-induced osteoarthritis model. Acta Orthop Traumatol Turc 2016;50:458-63. doi: 10.1016/j.aott.2016.07.008
  • [13] Ayhan E, Kesmezacar H, Akgun I. Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World J Orthop 2014;5:351-61. doi: 10.5312/wjo.v5.i3.351
  • [14] Akman Y E, Sukur E, Senel A, Sukur N E O, Talu C K, Ozturkmen Y. The comparison of the effects of a novel hydrogel compound and traditional hyaluronate following micro-fracture procedure in a rat full-thickness chondral defect model. Acta Orthop Traumatol Turc 2017;51:331-336. doi: 10.1016/j.aott.2017.04.001.
  • [15] Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomised, placebo-controlled clinical trial. Lancet 2001; 357:251-6.
  • [16] Bannuru R R, Schmid CH, Kent DM, Vaysbrot EE, Wong J B, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.Ann Intern Med 2015;162:46-54. doi: 10.7326/M14-1231.
  • [17] Murat N, Karadam B, Ozkal S, Karatosun V, Gidener S. Quantification of papain-induced rat osteoarthritis in relation to time with the Mankin score. Acta Orthop Traumatol Turc 2007; 41:233-7.
  • [18] Cen X, Liu Y, Wang S, Yang X, Shi Z, Liang X. Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis. Oral Dis 2018 ;24:404-411. doi: 10.1111/odi.12760. Epub 2017 Oct 4.
  • [19] Jones B. Q, Covey C. J, SINEATH M. H, Sineath Jr, M. H. Nonsurgical Management of Knee Pain in Adults. Am Fam Physician 2015;92:875-83.
  • [20] Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J at al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2012 ;64:465-74.
  • [21] American Academy of Orthopaedic Surgeons (AAOS). Treatment of osteoarthritis of the knee. Evidence-based guideline. 2nd edition. AAOS 2013 May 18 PDF, summary can be found at AAOS 2013 May 18 PDF.
  • [22] McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage 2014;22:363-88. doi: 10.1016/j.joca.2014.01.003.
  • [23] O’Hanlon CE, Newberry SJ, Booth M, et al. Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. Systematic reviews 2016 ;5:186.
  • [24] Rutjes AW, Jüni P, da Costa BR, Trelle S, Nüesch E, Reichenbach S. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med 2012;157:180-91. doi: 10.7326/0003-4819-157-3- 201208.070.00473.
  • [25] Fibel KH, Hillstrom HJ, Halpern BC. State-of-the-Art management of knee osteoarthritis. World J Clin Cases 2015 ;3:89-101. doi: 10.12998/wjcc.v3.i2.89.

Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid

Year 2019, Volume: 32 Issue: 3, 112 - 117, 31.10.2019
https://doi.org/10.5472/marumj.637180

Abstract

Objectives: The main purpose of this study was to determine a comparison between the chondroprotective efficacy of intra-articular

administrations of glucosamine sulphate (GS) and hyaluronic acid (HA) in the experimental knee osteoarthritis model in rats.

Materials and Methods: Forty-five rats were assigned to the following three groups: GS group (Group 1), HA group (Group 2), control

group (Group 3). The knee joints of the rats were seen macroscopically and the anterior cruciate ligaments were resected. Two weeks

after surgery, an intra-articular injection was applied to each group for three weeks with 1 week interval. In the osteoarthritic rat knee

joints, the histopathological effects of tissue regeneration of GS and HA applications were compared with the control group.

Results: The total Mankin Scale was 2.64±2.56, 3.58±3.9, 8.12±2.80 for the GS group, HA group and control group respectively.

According to these results, the GS and HA were superior to the control group. The values of the total Mankin scale, cartilage structure,

cellular abnormality, matrix staining and tidemark integrity of the GS group were lower than the values of the HA group but this

difference was not statistically significant.

Conclusion: According to the results of this study, intra-articular administration of GS for the management of osteoarthritis may be

beneficial for patients with knee osteoarthritis.

References

  • [1] Nelson AE, Allen KD, Golightly YM, Goode AP, Jordan JM. A systematic review of recommendations and guidelines for the management of osteoarthritis: The chronic osteoarthritis management initiative of the U.S. bone and joint initiative. Semin Arthritis Rheum 2014 ;43:701-12. doi: 10.1016/j.semarthrit.2013.11.012.
  • [2] Bannuru R R, Vaysbrot E E, Sullivan M C, McAlindon T E. Relative efficacy of hyaluronic acid in comparison with NSAIDs for knee osteoarthritis: a systematic review and metaanalysis. Semin Arthritis Rheum 2014;43:593-9. doi:10.1016/j. semarthrit.2013.10.002.
  • [3] Sen C, Güneş T, Saygi B, Erdem M, Köseoğlu R D, Kilic N. The chondroprotective effect of intra-articular hyaluronic acid at early stages of osteoarthritis: An experimental study in rabbits. Acta Orthop Traumatol Turc 2004;38:348-52.
  • [4] Özkan ÜF, Özkan K, Ramadan S, Güven Z. Chondroprotective effect of N-acetylglucosamine and hyaluronate in early stages of osteoarthritis an experimental study in rabbits. Bulletin of the NYU Hospital for Joint Diseases 2009; 67:352-7.
  • [5] Orak M. M, Ak D, Midi A, et al. Comparison of the effects of chronic intra-articular administration of tenoxicam, diclofenac, and methylprednisolone in healthy rats. Acta Orthop Traumatol Turc 2015;49:438-46. doi: 10.3944/ AOTT.2015.14.0312.
  • [6] Herrero-Beaumont G, Rovati LC, Castañeda S, Alvarez- Soria MA, Largo R. The reverse glucosamine sulfate pathway: application in knee osteoarthritis. Expert Opin Pharmacother. 2007 Feb;8(2):215-25. DOI: 10.1517/14656566.8.2.215
  • [7] Cen X, Liu Y, Wang S, Yang X, Shi Z, Liang X et al. Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis. Oral Dis. 2018 Apr;24(3):404-411. doi: 10.1111/odi.12760.
  • [8] Torrent A, Montell E, Vergés J, et al. SAT0547 Chondroprotective activity of acti-joint®, a combination of chondroitin sulphate, glucosamine and a natural ıngredient rich in hyaluronic acid. Ann Rheum Dis 2014;73(Suppl 2):789-9. doi: 10.1016/j.joca.2014.02.602
  • [9] Müller-Fassbender H, Bach GL, Haase W, Rovati LC, Setnikar I. Glucosamine sulfate compared to ibuprofen in osteoarthritis of the knee. Osteoarthritis Cartilage 1994; 2:61-9.
  • [10] van der Sluijs JA, Geesink RG, van der Linden AJ, Bulstra SK, Kuyer R, Drukker J. The reliability of the Mankin score for osteoarthritis. J Orthop Res 1992, 10:58–61. doi:10.1002/ jor.110.010.0107
  • [11] Heybeli N, Doral M N, Atay O A, Leblebicioglu G, Uzumcugil A. Intra-articular sodium hyaluronate injections after arthroscopic debridement for osteoarthritis of the knee: a prospective, randomized, controlled study. Acta Orthop Traumatol Turc 2008;42:221-7.
  • [12] Şükür E, Talu C, Akman Y E, Çirci E, Öztürkmen Y, Tüzüner T. Comparison of the chondroprotective effect of a novel hydrogel compound and traditional hyaluronate on rat cartilage in a papain-induced osteoarthritis model. Acta Orthop Traumatol Turc 2016;50:458-63. doi: 10.1016/j.aott.2016.07.008
  • [13] Ayhan E, Kesmezacar H, Akgun I. Intraarticular injections (corticosteroid, hyaluronic acid, platelet rich plasma) for the knee osteoarthritis. World J Orthop 2014;5:351-61. doi: 10.5312/wjo.v5.i3.351
  • [14] Akman Y E, Sukur E, Senel A, Sukur N E O, Talu C K, Ozturkmen Y. The comparison of the effects of a novel hydrogel compound and traditional hyaluronate following micro-fracture procedure in a rat full-thickness chondral defect model. Acta Orthop Traumatol Turc 2017;51:331-336. doi: 10.1016/j.aott.2017.04.001.
  • [15] Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: A randomised, placebo-controlled clinical trial. Lancet 2001; 357:251-6.
  • [16] Bannuru R R, Schmid CH, Kent DM, Vaysbrot EE, Wong J B, McAlindon TE. Comparative effectiveness of pharmacologic interventions for knee osteoarthritis: a systematic review and network meta-analysis.Ann Intern Med 2015;162:46-54. doi: 10.7326/M14-1231.
  • [17] Murat N, Karadam B, Ozkal S, Karatosun V, Gidener S. Quantification of papain-induced rat osteoarthritis in relation to time with the Mankin score. Acta Orthop Traumatol Turc 2007; 41:233-7.
  • [18] Cen X, Liu Y, Wang S, Yang X, Shi Z, Liang X. Glucosamine oral administration as an adjunct to hyaluronic acid injection in treating temporomandibular joint osteoarthritis. Oral Dis 2018 ;24:404-411. doi: 10.1111/odi.12760. Epub 2017 Oct 4.
  • [19] Jones B. Q, Covey C. J, SINEATH M. H, Sineath Jr, M. H. Nonsurgical Management of Knee Pain in Adults. Am Fam Physician 2015;92:875-83.
  • [20] Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J at al. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken). 2012 ;64:465-74.
  • [21] American Academy of Orthopaedic Surgeons (AAOS). Treatment of osteoarthritis of the knee. Evidence-based guideline. 2nd edition. AAOS 2013 May 18 PDF, summary can be found at AAOS 2013 May 18 PDF.
  • [22] McAlindon TE, Bannuru RR, Sullivan MC, et al. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage 2014;22:363-88. doi: 10.1016/j.joca.2014.01.003.
  • [23] O’Hanlon CE, Newberry SJ, Booth M, et al. Hyaluronic acid injection therapy for osteoarthritis of the knee: concordant efficacy and conflicting serious adverse events in two systematic reviews. Systematic reviews 2016 ;5:186.
  • [24] Rutjes AW, Jüni P, da Costa BR, Trelle S, Nüesch E, Reichenbach S. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med 2012;157:180-91. doi: 10.7326/0003-4819-157-3- 201208.070.00473.
  • [25] Fibel KH, Hillstrom HJ, Halpern BC. State-of-the-Art management of knee osteoarthritis. World J Clin Cases 2015 ;3:89-101. doi: 10.12998/wjcc.v3.i2.89.
There are 25 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Research
Authors

Zekeriya Okan Karaduman This is me 0000-0002-6719-3666

Yucel Istemı This is me 0000-0002-0074-4654

Elif Gulsah Bas This is me 0000-0003-0193-6495

Kazım Solak This is me 0000-0001-9320-0973

Ahmet Mıdı 0000-0002-6197-7654

Publication Date October 31, 2019
Published in Issue Year 2019 Volume: 32 Issue: 3

Cite

APA Karaduman, Z. O., Istemı, Y., Bas, E. G., Solak, K., et al. (2019). Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid. Marmara Medical Journal, 32(3), 112-117. https://doi.org/10.5472/marumj.637180
AMA Karaduman ZO, Istemı Y, Bas EG, Solak K, Mıdı A. Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid. Marmara Med J. October 2019;32(3):112-117. doi:10.5472/marumj.637180
Chicago Karaduman, Zekeriya Okan, Yucel Istemı, Elif Gulsah Bas, Kazım Solak, and Ahmet Mıdı. “Chondroprotective Efficiencies of Intra-Articular Treatment of Glucosamine Sulfate and Hyaluronic Acid”. Marmara Medical Journal 32, no. 3 (October 2019): 112-17. https://doi.org/10.5472/marumj.637180.
EndNote Karaduman ZO, Istemı Y, Bas EG, Solak K, Mıdı A (October 1, 2019) Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid. Marmara Medical Journal 32 3 112–117.
IEEE Z. O. Karaduman, Y. Istemı, E. G. Bas, K. Solak, and A. Mıdı, “Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid”, Marmara Med J, vol. 32, no. 3, pp. 112–117, 2019, doi: 10.5472/marumj.637180.
ISNAD Karaduman, Zekeriya Okan et al. “Chondroprotective Efficiencies of Intra-Articular Treatment of Glucosamine Sulfate and Hyaluronic Acid”. Marmara Medical Journal 32/3 (October 2019), 112-117. https://doi.org/10.5472/marumj.637180.
JAMA Karaduman ZO, Istemı Y, Bas EG, Solak K, Mıdı A. Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid. Marmara Med J. 2019;32:112–117.
MLA Karaduman, Zekeriya Okan et al. “Chondroprotective Efficiencies of Intra-Articular Treatment of Glucosamine Sulfate and Hyaluronic Acid”. Marmara Medical Journal, vol. 32, no. 3, 2019, pp. 112-7, doi:10.5472/marumj.637180.
Vancouver Karaduman ZO, Istemı Y, Bas EG, Solak K, Mıdı A. Chondroprotective efficiencies of intra-articular treatment of glucosamine sulfate and hyaluronic acid. Marmara Med J. 2019;32(3):112-7.