Research Article
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Year 2024, Volume: 37 Issue: 2, 178 - 184, 31.05.2024
https://doi.org/10.5472/marumj.1484705

Abstract

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. CA Cancer J Clin 2021;71:209-49. doi:10.3322/caac.21660
  • Globocan. Cancer today. International Agency for research. Published 2020. Accessed July 8, 2023. https://gco.iarc.fr/ today/fact-sheets-populations
  • Momenimovahed Z, Salehiniya H. Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer Res Treat 2019;11:151-64. doi:10.2147/ BCTT.S176070
  • Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K. Body fatness and cancer — Viewpoint of the IARC working Group. N Engl J Med 2016;375:794-8. doi:10.1056/ NEJMsr1606602
  • Muscaritoli M, Anker SD, Argilés J, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “ cachexiaanorexia in chronic wasting diseases” and “ nutrition in geriatrics.” . Clinical Nutr 2010;29:154-9. doi:10.1016/j. clnu.2009.12.004
  • Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS. Sarcopenia. J Lab Clin Med 2001;137:231-43. doi:10.1067/ mlc.2001.113504
  • Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39:412-23. doi:10.1093/ageing/afq034
  • Prado CM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet 2008;9:629-35. doi:10.1016/ S1470-2045(08)70153-0
  • Rossi F, Valdora F, Barabino E, Calabrese M, Tagliafico AS. Muscle mass estimation on breast magnetic resonance imaging in breast cancer patients: comparison between psoas muscle area on computer tomography and pectoralis muscle area on MRI. Eur Radiol 2019;29:494-500. doi:10.1007/ s00330.018.5663-0
  • Shen W, Punyanitya M, Wang ZM, et al. Total body skeletal muscle and adipose tissue volumes: Estimation from a single abdominal cross-sectional image. J Appl Physiol 2004;97:2333- 8. doi:10.1152/japplphysiol.00744.2004
  • Jones KI, Doleman B, Scott S, Lund JN, Williams JP. Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications. Colorectal Dis 2015;17:O20-O26. doi:10.1111/ codi.12805
  • Tosato M, Marzetti E, Cesari M, et al. Measurement of muscle mass in sarcopenia: from imaging to biochemical markers. Aging 2017;29:19-27. doi:10.1007/s40520.016.0717-0
  • Sanders KJC, Degens JHRJ, Dingemans AMC, Schols AMWJ. Cross-sectional and longitudinal assessment of muscle from regular chest computed tomography scans: L1 and pectoralis muscle compared to L3 as reference in non-small cell lung cancer. Int Journal COPD 2019;14:781-9. doi:10.2147/COPD. S194003
  • Hemke R, Buckless C, Torriani M. Quantitative imaging of body composition. Semin Radiol 2020;24:375-85. doi:10.1055/s-0040.170.8824 [15] Pi-Sunyer FX. Obesity: criteria and classification. Proc Nutr Soc 2000;59:505-9. doi:10.1017/s002.966.5100000732
  • Lee JS, Kim YS, Kim EY, Jin W. Prognostic significance of CT-determined sarcopenia in patients with advanced gastric cancer. PLoS ONE 2018;13:e0202700. doi:10.1371/journal. pone.0202700
  • Go SI, Park MJ, Song HN, et al. A comparison of pectoralis versus lumbar skeletal muscle indices for defining sarcopenia in diffuse large B-cell lymphoma – two are better than one. Oncotarget 2017;8:47007-19. doi:10.18632/oncotarget.16552
  • Kinsey C M, San José Estépar R, van der Velden J, Cole BF, Christiani DC, Washko GR. Lower pectoralis muscle area is associated with a worse overall survival in non–small cell lung cancer. Cancer Epidemiol Biomarkers Prev 2017;26:38-43. doi: 10.1158/1055-9965.EPI-15-1067
  • Prado CMM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet 2008;9:629-35. doi:10.1016/ S1470-2045(08)70153-0
  • Aleixo GFP, Williams GR, Nyrop KA, Muss HB, Shachar SS. Muscle composition and outcomes in patients with breast cancer: meta-analysis and systematic review. Breast Cancer Res Treat 2019;177:569-79. doi:10.1007/s10549.019.05352-3
  • Rossi F, Valdora F, Bignotti B, Torri L, Succio G, Tagliafico AS. Evaluation of body Computed Tomography-determined sarcopenia in breast cancer patients and clinical outcomes: A systematic review. Cancer Treat Res 2019;21:100154. doi:10.1016/j.ctarc.2019.100154
  • Zhang XM, Dou QL, Zeng Y, Yang Y, Cheng ASK, Zhang WW. Sarcopenia as a predictor of mortality in women with breast cancer: A meta-analysis and systematic review. BMC Cancer 2020;20:172. doi:10.1186/s12885.020.6645-6
  • Del Fabbro E, Parsons H, Warneke CL, et al. The relationship between body composition and response to neoadjuvant chemotherapy in women with operable breast cancer. Oncologist 2012;17:1240-5. doi:10.1634/ theoncologist.2012-0169
  • McDonald MLN, Diaz AA, Ross JC, et al. Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. a cross-sectional study. Ann Thorac Surg 2014;11:326-34. doi:10.1513/AnnalsATS.201307-229OC
  • Teigen LM, John R, Kuchnia AJ, et al. Preoperative pectoralis muscle quantity and attenuation by computed tomography are novel and powerful predictors of mortality after left ventricular assist device implantation. Circ Heart Fail 2017;10:e004069. doi:10.1161/CIRCHEARTFAILURE.117.004069
  • Hocaoglu E, Ors S, Yildiz O, Inci E. Correlation of pectoralis muscle volume and density with severity of COVID-19 pneumonia in adults. Acad Radiol 2021;28:166-72. doi:10.1016/j.acra.2020.11.017
  • Meyer HJ, Kardas H, Schramm D, et al. CT-defined pectoralis muscle mass and muscle density are associated with mortality in acute pulmonary embolism. A multicenter analysis. Clin Nutr 2023;42:1036-40. doi:10.1016/j.clnu.2023.04.022
  • Villaseñor A, Ballard-Barbash R, Baumgartner K, et al. Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study. J Cancer Survivorship 2012;6:398- 406. doi:10.1007/s11764.012.0234-x
  • Foukakis T, Bergh J. Prognostic and predictive factors in early, non-metastatic breast cancer. Dizon Ed UpToDate 2016.
  • Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999;341:1097-105. doi:10.1056/ NEJM199.910.073411501
  • Obesity and overweight. Accessed July 8, 2023. https:// www.who.int/news-room/fact-sheets/detail/obesity-andoverweight
  • Flegal KM, Graubard BI, Williamson DF, Gail MH. Causespecific excess deaths associated with underweight, overweight, and obesity. JAMA 2007;298:2028-37. doi:10.1001/jama.298.17.2028
  • Van Den Brandt PA, Spiegelman D, Yaun SS, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 2000;152:514-27. doi:10.1093/aje/152.6.514
  • White AJ, Nichols HB, Bradshaw PT, Sandler DP. Overall and central adiposity and breast cancer risk in the sister study. Cancer 2015;121:3700-8. doi:10.1002/cncr.29552

Evaluation of sarcopenia-associated survival in breast cancer with computed tomography-based pectoral muscle area measurements

Year 2024, Volume: 37 Issue: 2, 178 - 184, 31.05.2024
https://doi.org/10.5472/marumj.1484705

Abstract

Objective: Breast cancer is the most common and deadly female cancer. In breast cancer cases, survival is closely related to muscle
mass, which is one of the components of body composition. Our aim was to investigate the usefulness of computed-tomography (CT)-
based pectoral muscle measurements in detecting sarcopenia in patients with non-metastatic breast cancer and the relationship of
these measurements with survival.
Patients and Methods: Our study included 62 adult female breast cancer cases diagnosed with breast cancer between January 2012 and
January 2018 and without metastasis in positron emission tomography/CT (PET/CT) examination obtained for pre-treatment staging.
To evaluate sarcopenia, skeletal muscle index (SMI) and pectoral muscle index (PMI) were calculated by measuring pectoral muscle
area and skeletal muscle area at L3 vertebra level on PET/CT images.
Results: Deceased patients were significantly older (Median=73.90, IQR=27.04) than surviving patients (Median=54.60, IQR=13.37,
p=0.025) and were diagnosed with cancer later in life (Median=63.92 IQR=30.16’ vs. Median=47.51 IQR=15.0, p=0.030). When the
threshold of 31 cm2/m2 was selected, there was a statistically significant difference in survival between sarcopenic and non-sarcopenic
groups (p=0.031).
Conclusion: In conclusion, the presence of sarcopenia in female breast cancer cases is a parameter that affects survival and can be
measured using radiological imaging methods. In addition to the measurements accepted in the literature regarding sarcopenia,
pectoral muscle measurements can be chosen as an alternative method in the diagnosis of sarcopenia.

References

  • Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA. CA Cancer J Clin 2021;71:209-49. doi:10.3322/caac.21660
  • Globocan. Cancer today. International Agency for research. Published 2020. Accessed July 8, 2023. https://gco.iarc.fr/ today/fact-sheets-populations
  • Momenimovahed Z, Salehiniya H. Epidemiological characteristics of and risk factors for breast cancer in the world. Breast Cancer Res Treat 2019;11:151-64. doi:10.2147/ BCTT.S176070
  • Lauby-Secretan B, Scoccianti C, Loomis D, Grosse Y, Bianchini F, Straif K. Body fatness and cancer — Viewpoint of the IARC working Group. N Engl J Med 2016;375:794-8. doi:10.1056/ NEJMsr1606602
  • Muscaritoli M, Anker SD, Argilés J, et al. Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “ cachexiaanorexia in chronic wasting diseases” and “ nutrition in geriatrics.” . Clinical Nutr 2010;29:154-9. doi:10.1016/j. clnu.2009.12.004
  • Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS. Sarcopenia. J Lab Clin Med 2001;137:231-43. doi:10.1067/ mlc.2001.113504
  • Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010;39:412-23. doi:10.1093/ageing/afq034
  • Prado CM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet 2008;9:629-35. doi:10.1016/ S1470-2045(08)70153-0
  • Rossi F, Valdora F, Barabino E, Calabrese M, Tagliafico AS. Muscle mass estimation on breast magnetic resonance imaging in breast cancer patients: comparison between psoas muscle area on computer tomography and pectoralis muscle area on MRI. Eur Radiol 2019;29:494-500. doi:10.1007/ s00330.018.5663-0
  • Shen W, Punyanitya M, Wang ZM, et al. Total body skeletal muscle and adipose tissue volumes: Estimation from a single abdominal cross-sectional image. J Appl Physiol 2004;97:2333- 8. doi:10.1152/japplphysiol.00744.2004
  • Jones KI, Doleman B, Scott S, Lund JN, Williams JP. Simple psoas cross-sectional area measurement is a quick and easy method to assess sarcopenia and predicts major surgical complications. Colorectal Dis 2015;17:O20-O26. doi:10.1111/ codi.12805
  • Tosato M, Marzetti E, Cesari M, et al. Measurement of muscle mass in sarcopenia: from imaging to biochemical markers. Aging 2017;29:19-27. doi:10.1007/s40520.016.0717-0
  • Sanders KJC, Degens JHRJ, Dingemans AMC, Schols AMWJ. Cross-sectional and longitudinal assessment of muscle from regular chest computed tomography scans: L1 and pectoralis muscle compared to L3 as reference in non-small cell lung cancer. Int Journal COPD 2019;14:781-9. doi:10.2147/COPD. S194003
  • Hemke R, Buckless C, Torriani M. Quantitative imaging of body composition. Semin Radiol 2020;24:375-85. doi:10.1055/s-0040.170.8824 [15] Pi-Sunyer FX. Obesity: criteria and classification. Proc Nutr Soc 2000;59:505-9. doi:10.1017/s002.966.5100000732
  • Lee JS, Kim YS, Kim EY, Jin W. Prognostic significance of CT-determined sarcopenia in patients with advanced gastric cancer. PLoS ONE 2018;13:e0202700. doi:10.1371/journal. pone.0202700
  • Go SI, Park MJ, Song HN, et al. A comparison of pectoralis versus lumbar skeletal muscle indices for defining sarcopenia in diffuse large B-cell lymphoma – two are better than one. Oncotarget 2017;8:47007-19. doi:10.18632/oncotarget.16552
  • Kinsey C M, San José Estépar R, van der Velden J, Cole BF, Christiani DC, Washko GR. Lower pectoralis muscle area is associated with a worse overall survival in non–small cell lung cancer. Cancer Epidemiol Biomarkers Prev 2017;26:38-43. doi: 10.1158/1055-9965.EPI-15-1067
  • Prado CMM, Lieffers JR, McCargar LJ, et al. Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study. Lancet 2008;9:629-35. doi:10.1016/ S1470-2045(08)70153-0
  • Aleixo GFP, Williams GR, Nyrop KA, Muss HB, Shachar SS. Muscle composition and outcomes in patients with breast cancer: meta-analysis and systematic review. Breast Cancer Res Treat 2019;177:569-79. doi:10.1007/s10549.019.05352-3
  • Rossi F, Valdora F, Bignotti B, Torri L, Succio G, Tagliafico AS. Evaluation of body Computed Tomography-determined sarcopenia in breast cancer patients and clinical outcomes: A systematic review. Cancer Treat Res 2019;21:100154. doi:10.1016/j.ctarc.2019.100154
  • Zhang XM, Dou QL, Zeng Y, Yang Y, Cheng ASK, Zhang WW. Sarcopenia as a predictor of mortality in women with breast cancer: A meta-analysis and systematic review. BMC Cancer 2020;20:172. doi:10.1186/s12885.020.6645-6
  • Del Fabbro E, Parsons H, Warneke CL, et al. The relationship between body composition and response to neoadjuvant chemotherapy in women with operable breast cancer. Oncologist 2012;17:1240-5. doi:10.1634/ theoncologist.2012-0169
  • McDonald MLN, Diaz AA, Ross JC, et al. Quantitative computed tomography measures of pectoralis muscle area and disease severity in chronic obstructive pulmonary disease. a cross-sectional study. Ann Thorac Surg 2014;11:326-34. doi:10.1513/AnnalsATS.201307-229OC
  • Teigen LM, John R, Kuchnia AJ, et al. Preoperative pectoralis muscle quantity and attenuation by computed tomography are novel and powerful predictors of mortality after left ventricular assist device implantation. Circ Heart Fail 2017;10:e004069. doi:10.1161/CIRCHEARTFAILURE.117.004069
  • Hocaoglu E, Ors S, Yildiz O, Inci E. Correlation of pectoralis muscle volume and density with severity of COVID-19 pneumonia in adults. Acad Radiol 2021;28:166-72. doi:10.1016/j.acra.2020.11.017
  • Meyer HJ, Kardas H, Schramm D, et al. CT-defined pectoralis muscle mass and muscle density are associated with mortality in acute pulmonary embolism. A multicenter analysis. Clin Nutr 2023;42:1036-40. doi:10.1016/j.clnu.2023.04.022
  • Villaseñor A, Ballard-Barbash R, Baumgartner K, et al. Prevalence and prognostic effect of sarcopenia in breast cancer survivors: the HEAL Study. J Cancer Survivorship 2012;6:398- 406. doi:10.1007/s11764.012.0234-x
  • Foukakis T, Bergh J. Prognostic and predictive factors in early, non-metastatic breast cancer. Dizon Ed UpToDate 2016.
  • Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J Med 1999;341:1097-105. doi:10.1056/ NEJM199.910.073411501
  • Obesity and overweight. Accessed July 8, 2023. https:// www.who.int/news-room/fact-sheets/detail/obesity-andoverweight
  • Flegal KM, Graubard BI, Williamson DF, Gail MH. Causespecific excess deaths associated with underweight, overweight, and obesity. JAMA 2007;298:2028-37. doi:10.1001/jama.298.17.2028
  • Van Den Brandt PA, Spiegelman D, Yaun SS, et al. Pooled analysis of prospective cohort studies on height, weight, and breast cancer risk. Am J Epidemiol 2000;152:514-27. doi:10.1093/aje/152.6.514
  • White AJ, Nichols HB, Bradshaw PT, Sandler DP. Overall and central adiposity and breast cancer risk in the sister study. Cancer 2015;121:3700-8. doi:10.1002/cncr.29552
There are 33 citations in total.

Details

Primary Language English
Subjects Surgery (Other)
Journal Section Original Research
Authors

Beyza Nur Kuzan 0000-0002-5001-3649

Nargiz Majidova 0000-0002-2575-5819

Can Ilgın 0000-0003-1751-8546

Hulya Arslan This is me 0000-0001-5831-5740

Meltem Kursun This is me 0000-0003-0579-3655

Salih Ozguven This is me 0000-0002-2790-7206

Vedat Bayoğlu 0000-0002-0481-1084

Onur Buğdaycı 0000-0002-6011-2720

Perran Fulden Yumuk 0000-0001-8650-299X

Handan Kaya This is me 0000-0002-1147-4178

Publication Date May 31, 2024
Published in Issue Year 2024 Volume: 37 Issue: 2

Cite

APA Kuzan, B. N., Majidova, N., Ilgın, C., Arslan, H., et al. (2024). Evaluation of sarcopenia-associated survival in breast cancer with computed tomography-based pectoral muscle area measurements. Marmara Medical Journal, 37(2), 178-184. https://doi.org/10.5472/marumj.1484705
AMA Kuzan BN, Majidova N, Ilgın C, Arslan H, Kursun M, Ozguven S, Bayoğlu V, Buğdaycı O, Yumuk PF, Kaya H. Evaluation of sarcopenia-associated survival in breast cancer with computed tomography-based pectoral muscle area measurements. Marmara Med J. May 2024;37(2):178-184. doi:10.5472/marumj.1484705
Chicago Kuzan, Beyza Nur, Nargiz Majidova, Can Ilgın, Hulya Arslan, Meltem Kursun, Salih Ozguven, Vedat Bayoğlu, Onur Buğdaycı, Perran Fulden Yumuk, and Handan Kaya. “Evaluation of Sarcopenia-Associated Survival in Breast Cancer With Computed Tomography-Based Pectoral Muscle Area Measurements”. Marmara Medical Journal 37, no. 2 (May 2024): 178-84. https://doi.org/10.5472/marumj.1484705.
EndNote Kuzan BN, Majidova N, Ilgın C, Arslan H, Kursun M, Ozguven S, Bayoğlu V, Buğdaycı O, Yumuk PF, Kaya H (May 1, 2024) Evaluation of sarcopenia-associated survival in breast cancer with computed tomography-based pectoral muscle area measurements. Marmara Medical Journal 37 2 178–184.
IEEE B. N. Kuzan, “Evaluation of sarcopenia-associated survival in breast cancer with computed tomography-based pectoral muscle area measurements”, Marmara Med J, vol. 37, no. 2, pp. 178–184, 2024, doi: 10.5472/marumj.1484705.
ISNAD Kuzan, Beyza Nur et al. “Evaluation of Sarcopenia-Associated Survival in Breast Cancer With Computed Tomography-Based Pectoral Muscle Area Measurements”. Marmara Medical Journal 37/2 (May 2024), 178-184. https://doi.org/10.5472/marumj.1484705.
JAMA Kuzan BN, Majidova N, Ilgın C, Arslan H, Kursun M, Ozguven S, Bayoğlu V, Buğdaycı O, Yumuk PF, Kaya H. Evaluation of sarcopenia-associated survival in breast cancer with computed tomography-based pectoral muscle area measurements. Marmara Med J. 2024;37:178–184.
MLA Kuzan, Beyza Nur et al. “Evaluation of Sarcopenia-Associated Survival in Breast Cancer With Computed Tomography-Based Pectoral Muscle Area Measurements”. Marmara Medical Journal, vol. 37, no. 2, 2024, pp. 178-84, doi:10.5472/marumj.1484705.
Vancouver Kuzan BN, Majidova N, Ilgın C, Arslan H, Kursun M, Ozguven S, Bayoğlu V, Buğdaycı O, Yumuk PF, Kaya H. Evaluation of sarcopenia-associated survival in breast cancer with computed tomography-based pectoral muscle area measurements. Marmara Med J. 2024;37(2):178-84.