Melatonin and the pathophysiology of

Year 2010, Volume: 14 Issue: 1, 1 - 9, 03.03.2014

Russel Reiter Lorena Fuentes-broto Sergio Paredes Dun-xian Tan Joaquin Garcia

Abstract

Melatonin and the pathophysiology of cellular membranes

Abstract

ABSTRACT: The ability of melatonin to influence the physiology of cell membranes is reviewed
in this report. Publications related to this field from 1993 – present. Melatonin is a
ubiquitously acting indoleamine which is associated with a variety of important functions
within both unicellular and multicellular organisms. By virtue of its ability to protect lipids
from free radical damage, melatonin is remarkably beneficial in preserving the morphological
and functional integrity of cell membranes. In doing so, it reduces the quantity of oxidized
lipids in membranes and maintains them at optimal fluidity, i.e., prevents them from
becoming rigid. This contributes significantly to the function of proteins (receptors, channels,
pores, etc.) in the cell membranes and helps in preserving the normal physiology of the
cells. In addition to these indirect effects of melatonin on membrane function, there is evidence
that this indoleamine also may act directly on channels assisting membranes in maintaining
proper ion gradients and current. The role of melatonin in the functioning of membrane
channels and pores is an area of research that should be experimentally exploited.
KEY WORDS: Melatonin, cell membranes, lipid peroxidation, membrane channels, membrane
pores, cell membrane receptors

Keywords

Melatonin, cell membranes, lipid peroxidation, membrane channels, membrane pores, cell membrane receptors

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