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Yara İyileşmesi ve Oksidatif Stres

Year 2014, Volume: 18 Issue: 3, 153 - 158, 12.09.2014

Abstract

Aerobik hücrelerin normal metabolik yolaklarında bulunan

çeşitli enzimler ile travma, enfeksiyon, reperfüzyon ve

inflamasyon gibi çevresel faktörler reaktif oksijen türlerini

(ROT) oluşturur. Bu radikaller bir veya birden fazla

eşleşmemiş elektron içeren moleküller olup, yüksek kimyasal

aktivitelerinden dolayı hücresel makromoleküllerin hasarına

neden olurlar. Son yıllarda oksidatif stresin hem savunma

sisteminde hem de yara iyileşmesinde de rol aldığı birçok

çalışmada ortaya konmuştur. Diğer taraftan, yara

iyileşmesinde büyük bir role sahip olan ROT’un etki

mekanizmasıtam olarak aydılatıamamışı. Bu nedenle,

ROT’un oluşmu ve oluşn bu üülerin detoksifikasyonu

yara iyileşesinde büü öem kazanmaktadı. Bu da tedavi

içn yeni yötemlerin gelişesine öemli katkıar

sağayacaktı. Bu çlışada, yara iyileşesinde rolüolan

çştli antioksidan moleküler ile ROT’ un detoksifiye

enzimleri anlatıacaktı.

Anahtar Kelimeler: Antioksidan, oksidatif stres, reaktif

oksijen türleri, yara iyileşmesi

References

  • Witte MB, Barbul A. General principles of wound healing. Surg Clin N Amer 1997; 77: 509-28.
  • Ghosh K, Clark RA. Principles of tissue engineering. Editör: Lanza R, Langer R and Vacanti J. Wound Repair. II. Basic biology of wound repair, Elsevier Academic Press, 2007; 3rd Edition, 1149-1161.
  • Sen CK, Roy S. Redox signals in wound healing. Biochim Biophys Acta 2008; 1780:1348-61.
  • Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA. Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 2000;28: 1456-62.
  • Bayir H. Reactive oxygen species. Crit Care Med 2005; 33:498-501.
  • Blokhina O, Virolainen E, Fagerstedt KV. Antioxidants, oxidative damage and oxygen deprivation stress. Ann Bot 2003; 91:179-94.
  • Yager DR, Kulina RA, Gilman LA. Wound fluids: a window into the wound environment? Int J Low Extrem Wounds 2007; 6:262-72.
  • Yeoh-Ellerton S, Stacey MC. Iron and 8-isoprostane levels in acute and chronic wounds. J Invest Dermatol 2003; 121:918-25.
  • Kopal C, Deveci M, Oztürk S, Sengezer M. Effects of topical glutathione treatment in rat ischemic wound model. Ann Plast Surg 2007; 58:449-55.
  • Coudray C, Boucher F, Pucheu S, Leiris JD, Favier A. Relationship between severity of ischemia and oxidant scavenger enzyme activities in the isolated rat heart. Int J Biochem Cell Biol 1995; 27:61-9.
  • Fujita N, Sakaguchi I, Kobayashi H, Ikeda N, Kato Y, Minamino M, Ishii M. An extract of the root of Lithospermun erythrorhison accelerates wound healing in diabetic mice. Biol Pharm Bull 2003; 26:329-35.
  • Shetty S, Udupa S, Udupa L. Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of Ocimum sanctum Linn in rats. Evid Based Complement Alternat Med 2008; 5:95-101.
  • Rajasekaran NS, Nithya M, Rose C, Chandra TS. The effect of finger millet feeding on the early responses during the process of wound healing in diabetic rats. Biochim Biophys Acta 2004; 1689:190-201.
  • Doxey DL, Ng MC, Dill RE, Iacopino AM. Platelet-derived growth factor levels in wounds of diabetic rats. Life Sci 1995; 57:1111-23.
  • Phan TT, Wang L, See P, Grayer RJ, Chan SY, Lee ST. Phenolic compounds of Chromolaena odorata protect cultured skin cells from oxidative damage: Implication for cutaneous wound healing. Biol Pharm Bull 2001; 24:1373-9.
  • Oner OZ, Oğünç AV, Cingi A, Uyar SB, Yalçin AS, Aktan AO. Whey feeding suppresses the measurement of oxidative stress in experimental burn injury. Surg Today 2006; 36:376-81.
  • Parihar A, Parihar MS, Milner S, Bhat S. Oxidative stress and antioxidative mobilization in burn injury. Burns 2008; 34:6-17.
  • Latha B, Babu M. The involvement of free radicals in burn injury: Burns 2001; 27:309-17.
  • Fridovich I. Superoxide anion radical (O2 ), superoxide dismutases, and related matters. J Biol Chem 1997; 272:18515-7.
  • Chiumiento A, Lamponi S, Barbucci R, Domínguez A, Pérez Y, Villalonga R. Immobilizing Cu, Zn-superoxide dismutase in hydrogels of carboxymethylcellulose improves its stability and wound healing properties. Biochem (Mosc) 2006; 71: 1324-8.
  • Steiling H, Munz B, Werner S, Brauchle M. Different types of ROSScavenging enzymes are expressed during cutaneous wound repair. Exp Cell Res 1999; 247:484-94.
  • Perry JJ, Shin DS, Getzoff ED, Tainer JA. The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta 2010; 1804:245
  • Tudhope GR. Red cell catalase in health and in disease with reference to the enzyme activity in anaemia. Clin Sci 1967; 33:165-82.
  • Kapoor M, Kojima F, Appleton I, Kawai S, Crofford LJ. Major enzymatic pathways in dermal wound healing: Current understanding and future therapeutic targets. Curr Opin Investig Drugs 2006; 7:418
  • Munz B, Frank S, Hübner G, Olsen E, Werner S. A novel type of glutathione peroxidase :expression and regulation during wound repair. Biochem J 1997; 326:579-85.
  • Thiele JJ, Ekanayake-Mudiyanselage S. Vitamin E in human skin: organspecific physiology and considerations for its use in dermatology. Mol Aspects Med 2007; 28: 646-67.
Year 2014, Volume: 18 Issue: 3, 153 - 158, 12.09.2014

Abstract

References

  • Witte MB, Barbul A. General principles of wound healing. Surg Clin N Amer 1997; 77: 509-28.
  • Ghosh K, Clark RA. Principles of tissue engineering. Editör: Lanza R, Langer R and Vacanti J. Wound Repair. II. Basic biology of wound repair, Elsevier Academic Press, 2007; 3rd Edition, 1149-1161.
  • Sen CK, Roy S. Redox signals in wound healing. Biochim Biophys Acta 2008; 1780:1348-61.
  • Hensley K, Robinson KA, Gabbita SP, Salsman S, Floyd RA. Reactive oxygen species, cell signaling, and cell injury. Free Radic Biol Med 2000;28: 1456-62.
  • Bayir H. Reactive oxygen species. Crit Care Med 2005; 33:498-501.
  • Blokhina O, Virolainen E, Fagerstedt KV. Antioxidants, oxidative damage and oxygen deprivation stress. Ann Bot 2003; 91:179-94.
  • Yager DR, Kulina RA, Gilman LA. Wound fluids: a window into the wound environment? Int J Low Extrem Wounds 2007; 6:262-72.
  • Yeoh-Ellerton S, Stacey MC. Iron and 8-isoprostane levels in acute and chronic wounds. J Invest Dermatol 2003; 121:918-25.
  • Kopal C, Deveci M, Oztürk S, Sengezer M. Effects of topical glutathione treatment in rat ischemic wound model. Ann Plast Surg 2007; 58:449-55.
  • Coudray C, Boucher F, Pucheu S, Leiris JD, Favier A. Relationship between severity of ischemia and oxidant scavenger enzyme activities in the isolated rat heart. Int J Biochem Cell Biol 1995; 27:61-9.
  • Fujita N, Sakaguchi I, Kobayashi H, Ikeda N, Kato Y, Minamino M, Ishii M. An extract of the root of Lithospermun erythrorhison accelerates wound healing in diabetic mice. Biol Pharm Bull 2003; 26:329-35.
  • Shetty S, Udupa S, Udupa L. Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of Ocimum sanctum Linn in rats. Evid Based Complement Alternat Med 2008; 5:95-101.
  • Rajasekaran NS, Nithya M, Rose C, Chandra TS. The effect of finger millet feeding on the early responses during the process of wound healing in diabetic rats. Biochim Biophys Acta 2004; 1689:190-201.
  • Doxey DL, Ng MC, Dill RE, Iacopino AM. Platelet-derived growth factor levels in wounds of diabetic rats. Life Sci 1995; 57:1111-23.
  • Phan TT, Wang L, See P, Grayer RJ, Chan SY, Lee ST. Phenolic compounds of Chromolaena odorata protect cultured skin cells from oxidative damage: Implication for cutaneous wound healing. Biol Pharm Bull 2001; 24:1373-9.
  • Oner OZ, Oğünç AV, Cingi A, Uyar SB, Yalçin AS, Aktan AO. Whey feeding suppresses the measurement of oxidative stress in experimental burn injury. Surg Today 2006; 36:376-81.
  • Parihar A, Parihar MS, Milner S, Bhat S. Oxidative stress and antioxidative mobilization in burn injury. Burns 2008; 34:6-17.
  • Latha B, Babu M. The involvement of free radicals in burn injury: Burns 2001; 27:309-17.
  • Fridovich I. Superoxide anion radical (O2 ), superoxide dismutases, and related matters. J Biol Chem 1997; 272:18515-7.
  • Chiumiento A, Lamponi S, Barbucci R, Domínguez A, Pérez Y, Villalonga R. Immobilizing Cu, Zn-superoxide dismutase in hydrogels of carboxymethylcellulose improves its stability and wound healing properties. Biochem (Mosc) 2006; 71: 1324-8.
  • Steiling H, Munz B, Werner S, Brauchle M. Different types of ROSScavenging enzymes are expressed during cutaneous wound repair. Exp Cell Res 1999; 247:484-94.
  • Perry JJ, Shin DS, Getzoff ED, Tainer JA. The structural biochemistry of the superoxide dismutases. Biochim Biophys Acta 2010; 1804:245
  • Tudhope GR. Red cell catalase in health and in disease with reference to the enzyme activity in anaemia. Clin Sci 1967; 33:165-82.
  • Kapoor M, Kojima F, Appleton I, Kawai S, Crofford LJ. Major enzymatic pathways in dermal wound healing: Current understanding and future therapeutic targets. Curr Opin Investig Drugs 2006; 7:418
  • Munz B, Frank S, Hübner G, Olsen E, Werner S. A novel type of glutathione peroxidase :expression and regulation during wound repair. Biochem J 1997; 326:579-85.
  • Thiele JJ, Ekanayake-Mudiyanselage S. Vitamin E in human skin: organspecific physiology and considerations for its use in dermatology. Mol Aspects Med 2007; 28: 646-67.
There are 26 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Halil Aksoy

Özlem Bingöl Özakpınar This is me

Publication Date September 12, 2014
Published in Issue Year 2014 Volume: 18 Issue: 3

Cite

APA Aksoy, H., & Bingöl Özakpınar, Ö. (2014). Yara İyileşmesi ve Oksidatif Stres. Marmara Pharmaceutical Journal, 18(3), 153-158. https://doi.org/10.12991/mpj.2014187243
AMA Aksoy H, Bingöl Özakpınar Ö. Yara İyileşmesi ve Oksidatif Stres. Marmara Pharm J. November 2014;18(3):153-158. doi:10.12991/mpj.2014187243
Chicago Aksoy, Halil, and Özlem Bingöl Özakpınar. “Yara İyileşmesi Ve Oksidatif Stres”. Marmara Pharmaceutical Journal 18, no. 3 (November 2014): 153-58. https://doi.org/10.12991/mpj.2014187243.
EndNote Aksoy H, Bingöl Özakpınar Ö (November 1, 2014) Yara İyileşmesi ve Oksidatif Stres. Marmara Pharmaceutical Journal 18 3 153–158.
IEEE H. Aksoy and Ö. Bingöl Özakpınar, “Yara İyileşmesi ve Oksidatif Stres”, Marmara Pharm J, vol. 18, no. 3, pp. 153–158, 2014, doi: 10.12991/mpj.2014187243.
ISNAD Aksoy, Halil - Bingöl Özakpınar, Özlem. “Yara İyileşmesi Ve Oksidatif Stres”. Marmara Pharmaceutical Journal 18/3 (November 2014), 153-158. https://doi.org/10.12991/mpj.2014187243.
JAMA Aksoy H, Bingöl Özakpınar Ö. Yara İyileşmesi ve Oksidatif Stres. Marmara Pharm J. 2014;18:153–158.
MLA Aksoy, Halil and Özlem Bingöl Özakpınar. “Yara İyileşmesi Ve Oksidatif Stres”. Marmara Pharmaceutical Journal, vol. 18, no. 3, 2014, pp. 153-8, doi:10.12991/mpj.2014187243.
Vancouver Aksoy H, Bingöl Özakpınar Ö. Yara İyileşmesi ve Oksidatif Stres. Marmara Pharm J. 2014;18(3):153-8.