Characterization of Chrysophyllum albidum and Anacardium occidentale gums as wet and dry binders in ciprofloxacin tablets

Year 2016, Volume: 20 Issue: 2, 122 - 130, 11.03.2016

Ebere I. Okoye , Ifeoma Ndiwe

https://doi.org/10.12991/mpj.20162036047

Abstract

This study aimed to extract gums from Chrysophyllum albidum (CAG) fruit and Anacardium occidentale (AOG) bark tears; and characterize them as wet and dry binders in tablets. AOG and CAG were extracted using old and modified protocols respectively. CAG, polyvinylpyrrolidone (PVP) and gelatin (GTN) were used in wet granulation (WG), while CAG, AOG, pregelatinized starch (PGS) and hydroxypropylmethyl cellulose (HPMC) were used in direct compression (DC). Granules and powder blends were evaluated for flowability, while tablets underwent standard quality assessment to characterize and compare CAG and AOG to standard binders. CAG yield was influenced by anti-solvent and procedure used. Ethanol precipitated more gum than acetone; slurry from mixture of exocarp and mesocarp gave lower gum yield than mesocarp alone. On flowability, granules formulated with CAG flowed better than those containing PVP or GTN. Ciprofloxacin-excipients blends exhibited poor flow but can be rank in order of performance: PGS>AOG>CAG>HPMC. WG tablets possessed excellent mechanical properties, with binder efficiency ranked as: CAG>PVP>GTN. DC tablets had acceptable mechanical properties (CAG at concentrations ≥ 6%, AOG at ≥ 2%). Drug release from WG with CAG or PVP at 1- 2% was ≥ 80% in 30 min, but CAG significantly (p<0.05) reduced release at 3-4%, while GTN did at 2-4%. DC tablets (CAG or PGS) released ≥ 80% drug in 30 min. AOG imparted slow release, while HPMC allowed much slower release. CAG and AOG have good binder efficiencies, thus useable at low concentrations as wet and dry binders to produce tablets with acceptable pharmaceutical characteristics.

Keywords

Chrysophyllum albidum gum, Anacardium occidentale gum, wet and dry binders, ciprofloxacin tablets

Characterization of Chrysophyllum albidum and Anacardium occidentale gums as wet and dry binders in ciprofloxacin tablets

Abstract

References

• Okoye EI, Onyekweli1 AO, kunle OO, Arhewoh MI. Brittle fracture index (BFI) as a tool in the classification, grouping and ranking of some binders used in tablet formulation: Lactose tablets. Sci Res Essays 2010; 5: 500-6.
• Onyekweli AO, kunle OO, Okoye EI. Application of a newly developed multifunctional excipient in tablet formulation. Res J Pharm Tech 2013; 6:1019-31.
• Adebayo AH, Abolaji AO, kela R, Ayepola OO, Olorunfemi TB, Taiwo OS. Antioxidant activities of the leaves of Chrysophyllum albidum G. Pak J Pharm Sci 2011; 24: 545-51.
• Ige MM, Gbadamosi SO. Chemical composition and physicalproperties of african star apple (Chrysophyllum Albidum). Asset Series A 2007; 7: 37-42.
• Farmers seek effective utilisation of agbalumo. http:// dailyindependentnig.com/2015/04/farmers-seek-effective- utilisation-agbalumo/ (Accessed: 9th September, 2015)
• African star apple. http://www.harvestmall.com/afsa.html. (Accessed: 9th September, 2015).
• Bhosale RR, Osmani RAM, Padmaja C, Moin A. Formulation and evaluation of sustained release dosage form using modified cashew gum. Int J Pharm Pharm Sci 2015; 7:141-50.
• Oforikwakye k, Asantewaa y, kipo SL. Physicochemical and binding properties of cashew tree gum in metronidazole tablet formulations. Int J Pharm Pharm Sci 2010; 2:105-9.
• kumar A, Uma AR, Gopal M, Moin A. development of cashew gum and its derivatives for sustained released drug delivery system: by response surface methodology. Int J Pharm Pharm Sci 2014; 6: 476-84.
• Okoye EI, Onyekweli AO, Ohwoavworhua FO, kunle OO. Comparative study of some mechanical and release properties of paracetamol tablets formulated with cashew tree gum, povidone and gelatin as binders. Afri J Biotech 2009; 8:3970-3.
• Okoye EI, Onyekweli AO, Fatoki OO. Evaluation of Ld50 of cashew gum and the comparative study of its functionality in cotrimoxazole granule and tablet formulations. British J Pharmacol Toxicol 2012; 3:156-64.
• Ofori-kwakye k, Mfoafo kA, kipo SL, kuntworbe N, Boakye- Gyasi ME. development and evaluation of natural gum-based extended release matrix tablets of two model drugs of different water solubilities by direct compression. Saudi Pharm J 2016;24:82-91.
• Badwan AA, Rashid I, Al Omari MMH, darras FH. Chitin and chitosan as direct compression excipients in pharmaceutical applications. Mar drugs 2015; 13:1519-47.
• Ciprofloxacin Hydrochloride. http://www.Fda. Gov/downloads/drugs/Emergencypreparedness/ Bioterrorismanddrugpreparedness/Ucm130802.Pdf. (Accessed: 24th September 2015).
• Oliphant CM, Green GM. Quinolones: A comprehensive review. Am Fam Physician 2002; 65: 455-64.
• Fahmy R, kona R, dandu R, Xie w, Claycamp G, Hoag Sw. Quality by design I: Application of Failure Mode Effect Analysis (FMEA) and Plackett–Burman design of Experiments in the Identification of “Main Factors” in the Formulation and Process design Space for Roller-Compacted Ciprofloxacin Hydrochloride Immediate-Release Tablets. AAPS PharmSciTech 2012; 13:1243-54.
• Gaikwad Vd, yadav Vd, Gaikwad Md. Novel sustained release and swellable gastroretentive dosage form for ciprofloxacin hydrochloride. Int J Pharm Investig 2014; 4: 88–92.
• Arza ANk, Gonugunta CSR, Veerareddy PR. Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets. AAPS PharmSciTech 2009; 10:220-6.
• British Pharmaceutical Codex, 11th Edition. The Pharmaceutical Press, London. 1979, pp 510.
• Okoye EI, Onyekweli AO, kunle OO. Solid state characterization of Anacardium occidentale gum. Res J Appl Sci Engin Techn 2012; 4: 3709-16.
• Okoye EI, Awotunde T, Morales T. Comparative study of the functionality of povidone, gelatin and corn starch on Moringa oleifera leaf granule and capsule formulations. Am J Pharmtech Res 2013; 3:1-22.
• British Pharmacopoeia, Volume 4. Her Majesty Stationery Office, London. 2009, pp A449
• The International Pharmacopoeia Fifth Edition, 2015. Http:// Apps.who.Int/Phint/En/P/docf/. (Accessed 5th October 2015).
• Alebiowu G, Itiola OA. Effects of starches on the mechanical properties of paracetamol tablet formulations. II. Sorghum and plantain starches as disintegrants. Acta Pharma 2003; 53:313-20.
• Amid BT, Mirhosseini H. Effect of different purification techniques on the characteristics of heteropolysaccharide- protein biopolymer from durian (Durio zibethinus) seed. Molecules 2012; 17:10875-92.
• Cunha PLR, de Paula RCM, Feitosa JPA. Purification of guar gum for biological applications. Int J Biol Macromol 2007; 41: 324–31.
• Powder flow. http://www.pharmacopeia.Cn/V29240/ Usp29nf24s0_C1174.Html. (Accessed 20th december 2015).
• Niklas S, Reiche k, Heinämäki J, yliruusi J. Effect of moisture on powder flow properties of theophylline. Pharmaceutics 2010; 2: 275–90.
• Meeus L. direct compression versus granulation. Pharm Technol Europe 2011; 23:1-2.
• Miinea LA, Mehta R, kallam M, Farina JA, deorkar N. Evaluation and characteristics of a new direct compression performance excipient. Pharm Technol 2011; 35:1-8.
• Evelghem JV. Improving Tablet Quality with Compression to Equal Force Technology. Pharm Technol 2008. http://www. pharmtech.com/improving-tablet-quality-compression- equal-force-technology. (Accessed 4th March 2016)
• Rudnic EM, Schwartz JB. Oral solid dosage forms. In: The science and Practice of Pharmacy 21st Ed. Lppincott williams and wilkins, Philadelphia USA. 2006, pp 917.
• British Pharmacopoeia Vol. 4. Her Majesty Stationery Office, London. 2003, pp 2051.
• Uniformity of mass for single-dose preparations. The International Pharmacopoeia – 5th Edition, 2015. Http://Apps. who.Int/Phint/Pdf/B/Jb.7.5.3.Pdf. (Accessed 11th december 2015).
• Lawal MV, Odeniyi MA, Itiola OA. Effect of thermal and chemical modifications on the mechanical and release properties of paracetamol tablet formulations containing corn, cassava and sweet potato starches as filler-binders. Asian Pac J Trop Biomed 2015; 5: 585–90.
• Alebiowu G, Adebolu AA. disintegrant properties of paracetamol tablet formulation lubricated with co – processed lubricants. Farmacia 2009; 57: 500–10.
• USP monograph on ciprofloxacin hydrochloride tablet. http:// www.pharmacopeia.cn/v29240/usp29nf24s0_m17880.html. (Accessed 13th November 2015).
• Okoye EI. Improvement of the crystal stability and dissolution profile of metronidazole by composite formation with microcrystalline cellulose and cashew gum. J Pharm Allied Sci 2014;11: 2006-26.
• Avachat AM, Nandare dS. Effect of alcohol on drug release kinetics from hpmc-based matrix tablets using model drugs. dissol Technol 2014; February: 11-17.