Potensiyometrik PVC-membran ve grafit kaplı tel elektrot yöntemiyle haloperidol’ün ampulde ve idrarda miktar tayini

Year 2017, Volume: 21 Issue: 1, 110 - 120, 20.09.2016

Hazem Abu Shawish Hassan Tamous Asma A. Shaheen Khaled I. Abed Almonem Ahmed Awad Elgamel Wael S. Al-lham

https://doi.org/10.12991/marupj.259888

Abstract

Sensör P olarak isimlendirilen
yeni bir PVC membran ve sensör  G olarak
isimlendirilen grafit kaplı tel Haloperidol’ün (HP)  analizi için tanımlanmıştır. Elektrotlar P ve
G için sırasıyla;  Nernst denklemine göre
en yüksek tepe noktası her onlu grup  için
3.7×10-6–1.0×10-2 mol/L -5.8 x 10-7 – 1.0 x 10-2 mol/L derişim  aralığında 57.4±0.8 and 61.1±0.4 mV;
deteksiyon alt sınırı  (LO D) ise pH
aralığı 2.5–7.5 and 2.5-8.0 için 1.6 × 10-6 mol/L  ve 4.2×10-7 mol/L olarak bulunmuştur.
Tanımlanan sensörler  HP’ün diğer gişim
yapan bileşiklerden ayrılabilmesi için yüksek 
seçicilik göstermiştir. Bahsi geçen elektrotların kullanılmasıyla  HP’ün ampül dozaj formundan ve idrar
örneklerinden analizinin  başarıyla yapılabileceği
gösterilmiştir.  

Keywords

Potensiyometri, Haloperidol, kaplanmış tel elektrot, PVC membrane elektrot, iyon-seçici elektrot

Determination of haloperidol drug in ampoules and in urine samples using a potentiometric PVC-membrane and graphite coated wire electrodes

Abstract

A new PVC membrane, called sensor P, and graphite coated wire, called sensor g,  for haloperidol drug (HP) are described. The electrodes P and C exhibit a Nernstian slope of 57.4±0.8 and 61.1±0.4 mV per decade over a wide concentration range from 3.7×10^-6–1.0×10^-2 mol/L and 5.8 x 10^-7 – 1.0 x 10^-2 mol/L and the limit of detection (LOD) of 1.6 × 10^-6 mol/L and 4.2×10^-7 mol/L over the pH range of  2.5–7.5 and 2.5-8.0 respectively. The presented sensors  show a very good selectivity for HP drug over the common interfering chemical species. The proposed electrodes were successfully used for determination of HP drug in ampoules and in urine samples with satisfactory results.

Keywords

Potentiometry, Haloperidol drug, coated wire Electrode, PVC membranes electrode, Ion-selective electrode

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