The transition theory developed by Afaf İbrahim Meleis is a nursing theory aimed at defining changes in individuals’ lives and improving their health. Effects of such changes and transitions on individuals’ health differ from one person to another. Nurses assist patients in these transition times by developing different intervention methods for them. Meleis' s transition theory is of importance because it is based on nursing profession and has contributed to the emergence of nursing science. A female patient presented to a private health institution with complaints of fever (38.2°C) and sore throat. The result of the 2019-nCov test performed was positive and she was quarantined in a socially isolated room of the hospital. Uncertainty and fear of death due to COVID-19, a global epidemic, bring about serious consequences for patients. In this case report, in line with Meleis’ s transition theory, nursing care was planned for this 52-year-old woman diagnosed with 2019-nCov.