Uzun Süreli 32 Saatlik Aralıksız Vardiyalar, Kadın Pediatri Asistanında Progesteron, Il-1β, Tnf-a, Il-6, Eozinofil Sayısı ve Dikkat Performansını Artırır

Öz

Amaç: Çalışmada, kadın pediatri asistanlarında uzun süreli 32 saatlik aralıksız vardiyaların leptin, melatonin, seks hormonları, IL-1β, TNF-α, IL-6, hematolojik parametreler, uyku kalitesi ve dikkat performansı üzerine etkilerininin değerlendirilmesi amaçlamıştır. FPR).
Materyal ve Metot: 32 saat sürekli vardiyada (08:00-08:00 sonrası 08:00-17:00, n=10) çalışan FPR, gündüz saatlerinde (08:00-16: 00 saat, n=10) çalışan kadın sağlık profesyonelleri ile karşılaştırılmıştır.
Bulgular: Çalışmada; eozinofil oranı (p=0.015), hemoglobin (p=0.010), hematokrit (p=0.012), progesteron (p=0.008), TNF α, (p=0.000), IL-1beta ve (p= 0.003) IL-6 düzeyleri (p= 0.000) FPR’de anlamlı olarak yüksek bulundu. Ayrıca FPR’nin sabahları uyanmakta güçlük çektiği (p=0,000), kötü rüyalar gördüğü (p=0,040) ve uyku kalitesinin kötü olduğu (p=0,010) bulundu. FPR daha iyi dikkat performansı gösterdi (p=0.000).
Sonuç: FPR’de dikkat performansı daha yüksek olmasına rağmen, veriler uzun süreli sürekli 32 saatlik vardiya sisteminin inflamatuar yanıtı aktive ettiğini, over steroid üretimini bozduğunu ve uyku kalitesini azalttığını göstermektedir. Hep birlikte, bunlar iltihaplı hastalıklar veya üreme sorunları ile sonuçlanabilir.

Long-Term 32-Hours Continuous Shifts Increases Progesterone, IL-1β, TNF-α, IL-6, Eosinophil Count and Attention Performance in Female Pediatric Resident

Abstract

Aim: The study aimed at assessing effects of long-term 32-hours continuous shifts on leptin, melatonin, sex hormones, IL-1β, TNF-α, IL-6, hematological parameters, sleep quality and attention performance in female pediatric residents (FPR).
Materials and Methods: FPR working under 32 hours continuous shifts (08:00-08:00h after 08:00-17:00h, n=10) were compared to female health professionals working in day-time hours (08:00-16:00h, n=10). Vital parameters, glucose, leptin, melatonin, estrogen, progesterone, IL-1β, TNF-α, and IL-6 concentrations, complete blood count (CBC) and erythrocyte sedimentation rate (ESR) were measured. The participants were also requested to fill in sleep quality questionnaires and visual attention test.
Results: In the study; eosinophil ratio (p=0.015), hemoglobin (p=0.010), hematocrit (p=0.012), progesterone (p=0.008), TNF-α, (p=0.000), IL-1beta and (p= 0.003) IL-6 levels (p= 0.000) were found significantly higher in FPR. In addition, it was found that FPR had difficulty in waking up in the mornings (p = 0.000), had bad dreams (p = 0.040), and had poor sleep quality (p = 0.010). FPR had better attention performance (p=0.000).
Conclusion: Although attention performance was higher in FPR, data suggest that long-term continuous 32-hour shift system activates inflammatory response, disturbs ovarian steroid production and reduces sleep quality. Alltogether, these may culminate in inflammatory diseases or reproductive problems.  

Keywords

• Uyku
• uzun süreli aralıksız vardiya sistemi
• kadın
• sitokin
• hormon
• hematolojik parametreler

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