Effects of Royal Jelly Supplementation on Growth Plate Zones and Longitudinal Growth in Young Rats

Abstract

Kraliçe arıların ana besin öğesini oluşturan Arı sütü, işçi arıların mandibular bezlerinden salgılanmaktadır. Son yıllarda, ailelerin çocuklarının büyümesine yardımcı olmak için Arısütü’nü uygulamasında artış olduğu gözlenmektedir. Bu çalışmada arısütü verilen genç sıçanlarda büyüme plağı zonlarına olan etkisi ve hormonal etkilerini (östrodiol, büyüme hormone ve insulin benzeri büyüme faktörü-1) araştırdık. 30 adet 7 günlük sıçan randomize olarak iki gruba ayrıldı. Bir gruba annesütünün yanısıra 15 gün süresince gavaj yolu ile günde 50 mg/kg Arı sütü uygulandı. Çalışmanın sonunda RJ verilen grubun göre ortalama ağırlığı kontrol grubuna daha fazla ve ortalama kuyruk uzunlukları daha uzundu (p<0.001; p=0.04). Plazma büyüme hormonu ve östradiol seviyesi RJ g rubunda daha yüksek olarak sonuçlandı (p=0.03; p=0.04). Büyüme plağının uzunluğu RJ grubunda control grubuna göre daha uzun olduğu tespit edildi. Ayrıca büyüme plağının proliferative zonunda östrojen reseptör ekspresyonu RJ grubunda control grubuna göre daha fazla olduğu gözlendi (p<0.001). Çalışma sonunda büyüme plağı zonları, östrodiol, büyüme hormonu ve insulin benzeri büyüme faktörü-1 ölçüldü. Bu çalışma sonucunda Arı sütü’nün büyüme plağı zonlarında ve serumda östrodiol ile büyüme hormonunun artışı olduğu ancak büyüme plağının uzamasının Arısütünün potansiyel östrojenik etkisine bağlı olacağı belirtildi.

Keywords

• Royal Jelly,growth,growth hormone

References

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