mersin univ saglık bilim derg

Mersin Üniversitesi Sağlık Bilimleri Dergisi

1308-0830

Mersin University

Surgery (Other)

Cerrahi (Diğer)

Çocukluk çağı kronik Hepatit B hastalığının klinik seyir ve tedavisi ile Serum CD 95 (FAS) ve Nitrik Oksid düzeyleri arasındaki ilişkinin belirlenmesi

The correlation between clinical prognosis together with the treatment of chronic Hepatitis B infection and Serum CD 95 (FAS) and Nitric Oxide levels in children

https://orcid.org/0000-0003-0486-0422

Kont Özhan

Aylin

MERSİN ÜNİVERSİTESİ

https://orcid.org/0000-0001-6727-0070

Çoşkun

Mehmet Yavuz

GAZİANTEP ÜNİVERSİTESİ, TIP FAKÜLTESİ

12 18 2023

16 3 495 502 09 18 2023 10 17 2023

2008

Mersin Üniversitesi Sağlık Bilimleri Dergisi

Amaç: Nitrik oksid (NO) ve CD 95’ in (FAS) kronik hepatit B enfeksiyonlarında inflamasyonda ve apoptozisde rol oynadığı düşünülmektedir. Bu çalışmada, kronik hepatit B enfeksiyonu olan çocukların serum NO ve CD 95 düzeylerinin sağlıklı çocuklarla karşılaştırmalı olarak incelenmesi amaçlandı. Yöntem: Kronik hepatit B tanısı ile izlenen 1-18 yaş arası 69 hasta çalışmaya dahil edildi. Kronik inaktif hepatit B enfeksiyonu olan 32 hasta (21 erkek, 11 kız) grup 1 olarak, kronik aktif hepatit B enfeksiyonu olan 37 hasta (25 erkek, 12 kız) grup 2 olarak ve 32 sağlıklı çocuk (18 erkek, 14 kız) kontrol grubu olarak sınıflandırıldı. Serum NO ve CD 95 düzeyleri ölçüldü. Hasta ve kontrol grubu karşılaştırmaları yapıldı. Bulgular: Ortalama yaş grup 1’ de 10.1±3.1 yıl, grup 2’ de 9.3±3.3 yıl ve kontrol grubunda 9.2±1.8 yıl bulundu (p>0.05). Hasta grubu ve kontrol grubu arasında serum NO ve CD 95 düzeyleri anlamlı farklılık gösterdi (sırasıyla 72.2±36.9’a karşılık 38.5±17.3 mµ, p

Aim: Nitric oxide (NO) and CD 95 (FAS) are thought to play a role in inflammation and apoptosis in chronic hepatitis B infections. This study aimed to examine the serum NO and CD 95 levels of children with chronic hepatitis B infection in comparison with healthy children. Method: 69 patients between the ages of 1 and 18 who were diagnosed with chronic hepatitis B were included in the study. 32 patients (21 boys, 11 girls) with chronic inactive hepatitis B infection as group 1, 37 patients with chronic active hepatitis B infection (25 boys, 12 girls) as group 2 and 32 healthy children (18 boys, 14 girls) as control group were included. Serum NO and CD 95 levels were measured. Comparisons between patient and control groups were made. Results: The mean age was 10.1±3.1 years in group 1, 9.3±3.3 years in group 2 and 9.2±1.8 years in the control group (p>0.05). Serum NO and CD 95 levels showed significant differences between the patient group and the control group (72.2±36.9 vs. 38.5±17.3 mµ, p

Hepatit B virüs kronik hepatit B enfeksiyonu apoptozis CD 95 (FAS) nitrik oksid

Hepatitis B virus chronic hepatitis B infection apoptosis CD 95 (FAS) nitric oxide (NO)

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