mersin univ saglık bilim derg Mersin Üniversitesi Sağlık Bilimleri Dergisi 1308-0830 Mersin University 10.26559/mersinsbd.558520 Health Care Administration Sağlık Kurumları Yönetimi The relationship between Thyroid Stimulating Hormone - Anti Mullerian Hormone in women infertility Kadın infertilitesinde Tiroid Stimülan Hormon - Anti Müllerian hormon ilişkisi https://orcid.org/0000-0002-9494-1076 Çalıkoğlu İlker Mersin Şehir Eğitim ve Araştırma Hastanesi Biyokimya Laboratuarı https://orcid.org/0000-0003-1890-5863 Yazıcı Gürkan Mersin Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum AD https://orcid.org/0000-0002-2413-2695 Aykal Güzin Antalya Eğitim Araştırma Hastanesi Biyokimya Bölümü https://orcid.org/0000-0001-8146-4912 Taşdelen Bahar Mersin Üniversitesi Tıp Fakültesi Biyoistatistik AD 08 30 2019 12 2 284 292 04 27 2019 05 28 2019 Copyright © 2008, Mersin Üniversitesi Sağlık Bilimleri Dergisi 2008 Mersin Üniversitesi Sağlık Bilimleri Dergisi

Objective: Hypothyroidismmay be a risk for infertility, the relationship between increased ThyroidStimulating Hormone (TSH) andovarian reserve is discussed. Anti-Mullarian Hormone (AMH) is a good predictor of ovarian reserve.Weinvestigated the relationship between TSH and AMH levelsin infertile women and the effect of TSH on fertility. Methods: Age, weight, height, additional diseases and treatmenthistory of patients aged 19-40 years who were admitted to Mersin City HospitalGynecology and Obstetrics Clinic between 01.01.2018 and 01.03.2019 wereobtained from hospital records. Women data with similar demographiccharacteristics who were healthy, had at least one birth, applies to the samecenter for control on the same date were taken from records. Patients withpolycystic ovary, hirsutism, primary amenorrhea, menopausal conditions,endometriosis, known thyroid disease and treatment, cancer, obese, cachecticwere not included. Serum AMH and TSH levels were recorded. Results: The mean serum AMH and TSH levels of infertile (160) andfertile (34) women were compared. Mean AMH level in infertil women was3.01±1.56 and 1.65±1.70ng/ml in fertilizers (p=0.00002). TSH levels in infertilwomen were higher (2.91±1.26μIU/mL) than fertilizers (1.76±0.72μIU/mL) and itwas different at the statistical border (p=0.05). AMH-age(r=-0.34, p=0.01) and AMH-TSH levels were inversely correlated in infertil women(r=-0.20, p=0.0001). In fertilizers AMH levels were decreased with age(r=-0.40, p=0.01), but there was no correlation between AMH-TSH levels(r=-0.17,p=0,31). Conclusion: Our studysuggests negative relation between AMH-TSH levels in infertile women and TSHelevation should not be overlooked in the etiology of infertility.

AmaçHipotiroidizmin infertilitede riskfaktörü olabileceği, artmış Tiroid StimulanHormon (TSH) düzeyinin over rezerviyle ilişkisi tartışılmaktadır. AntiMüllerian Hormon (AMH) over rezervini belirlemede iyi bir belirteçtir. İnfertil kadınlarda serum ortalama TSH ile AMH düzeyleriarasındaki ilişkiyi ve TSH'ın fertiliteye etkisini araştırdık. Yöntem: Mersin Şehir Hastanesi Kadın Hastalıkları Doğumpolikliniğine 01.01.2018-1.03.2019arasında başvuran, infertilite tanılı, 19-40 yaş kadınların yaş, kilo, boy, ekhastalık, tedavi öyküleri ve kontrol amacıyla başvuran sağlıklı, en az birdoğum yapmış, benzer demografik özelliklere sahip kadınların verileri hastanekayıtlarından alındı. Polikistik Over, hirsutism, amenore, menapozal durumlar,endometriozis, bilinen tiroid bezi hastalığı olanlar ve tedavi alanlar, kansertanılılar, obezler, kaşektikler çalışmadan çıkarıldı. Başvuruda serum AMHve TSH düzeyleri bakılmışların değerlerikaydedildi. Bulgular: İnfertil(160) ve fertil (34) kadına ait ortalama serum AMH ve TSH düzeyleri karşılaştırıldı. İnfertillerde AMH düzeyi 1.65±1.70 fertillerde 3.01±1.56 ng/mlolup, istatistiksel farklıydı (p=0.00002). İnfertillerdeki TSH düzeyi (2.20±1.26 μIU/mL) fertillerden(1.76±0.72 μIU/mL) yüksek olup istatistiksel sınırda farklıydı (p=0.05).İnfertillerde AMH-yaş (r=-0.34, p=0.01) ve AMH-TSHdüzeyleri ters korele bulundu (r=-0.20, p=0,0001). Fertillerde serum AMH düzeyi yaş ile azalırken (r=-0.40, p=0.01),AMH-TSH düzeyleri arasında korelasyonizlenmedi (r=-0.17, p=0.31). Sonuç:Çalışmamız infertillerde AMH ve TSH düzeyleriarasındaki negatif ilişkiyi ve infertilite etiyolojisinde TSH yüksekliğinin gözden kaçırılmamasıgerektiğini düşündürmektedir.

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