Aim: Platelets play an important role in the pathogenesis of nephrotic syndrome, and the aim in this study is to evaluate platelet indices as markers of this disorder. Methods: A total of 39 patients with nephrotic syndrome, who were followed by the pediatric nephrology department in our center from January 2017 to January 2018, were included in the study. The participants were divided into two groups, as those with steroid-sensitive nephrotic syndrome (n= 26) and those with steroid-resistant nephrotic syndrome (n= 13). Laboratory parameters, including neutrophils, lymphocytes, white blood cells, platelet counts, mean platelet volume, platelet distribution width, plateletcrit and platelet large cell ratios were reviewed retrospectively. Similar parameters from a control group comprising 30 age- and sex-matched healthy subjects were also evaluated and compared with the study groups. Results: White blood cells, neutrophil, platelet and plateletcrit values were found to be greater in the nephrotic syndrome patients than in the controls [(10.83 ± 4.98 x103/µl, 8.96 ± 2.30 x103/µl, P= 0.043), (6.96 ± 4.95 x103/ µl, 4.54 ± 2.39 x103/ µl, P=0.010), (379.49 ± 120.87 x103/µl, 328.83 ± 69.42 x103/ µl, P=0.032), (0.38 ± 0.11%, 0.33 ± 0.06%, P=0.012) respectively]. Plateletcrit values were greater in the steroid-resistant nephrotic syndrome group when compared to the control group (0.42 ± 0.14%, 0.33 ± 0.06%) (P= 0.007). Conclusion: Plateletcrit could serve as a marker for steroid-resistant nephrotic syndrome, although further studies involving larger samples should be carried out to determine changes in platelet indices that occur in association with nephrotic syndrome.