med j west black sea

Medical Journal of Western Black Sea

2822-4302 2587-0602

Zonguldak Bulent Ecevit University

10.29058/mjwbs.1591828

Gastroenterology and Hepatology

Gastroenteroloji ve Hepatoloji

Non-Alkolik Yağlı Karaciğer Hastalığı Olan Çocuklarda Lipid Profilleri ve D Vitamini Düzeylerinin Yağlı Karaciğer Derecesi Üzerindeki Etkileri

Effects of Lipid Profiles and Vitamin D Levels on the Degree of Fatty Liver in Children with Non-Alcoholic Fatty Liver Disease

https://orcid.org/0000-0001-7632-2215

Gülseren

Arzu

Kayseri Şehir Hastanesi

https://orcid.org/0000-0002-2746-3799

Gulcu Taskin

Didem

Department of Pediatric Gastroenterology, Adana City Training and Research Hospital, Adana, Turkey

08 31 2025

9 2 181 186 11 26 2024 07 17 2025

2017

Medical Journal of Western Black Sea

Amaç: Çalışmanın amacı hepatosteatoz hastalarının D vitamini, trigliserit ve kolesterol düzeylerini sağlıklı kontrol hastalarıyla karşılaştırmaktır.Gereç ve Yöntemler: Çalışmamıza retrospektif olarak hepatosteatozlu 99 hasta ve sağlıklı kontrol hastaları dahil edildi. Çalışmaya dahiledilen hastalar 2020-2023 yılları arasında çocuk gastroenteroloji polikliniğine başvuran hastalardı.Bulgular: Çalışmamıza hepatosteatozlu 47 (%47,5) ve kontrol grubunda 52 (%52,5) olmak üzere toplam 99 hasta dahil edildi. Ortalama ALTdeğerleri hepatosteatoz ve kontrol gruplarında sırasıyla 35,2 ± 19,5 ve 28,3 ± 13,0 idi (P= 0,039). Ortalama trigliserit (136 ± 28 vs 125 ± 24;P= 0.042) ve kolesterol (165 ± 20 vs 154 ± 20; P= 0.010) düzeyleri hepatosteatoz grubunda kontrol grubuna göre daha yüksekti ve sonuçanlamlı olarak farklı bulundu. Ortalama D vitamini düzeyleri gruplar arasında farklılık göstermedi. Her iki grupta da D vitamini eksikliği yüksekbulundu, ancak gruplar arasında fark analiz edilmedi (%72.3 vs %61.5; P= 0.491).Sonuç: Hepatosteatozlu hastalarda trigliserit ve kolesterol düzeyleri daha yüksek bulundu. Açlık kan şekeri hepatosteatoz grubundadaha yüksektir. Bu sonuçlara ve literatüre dayanarak, hepatosteatozlu hastalar ilerleyen yıllarda metabolik sendrom ve ateroskleroz gibikardiyovasküler hastalıklar gibi önemli hastalıklar için risk oluşturmaktadır.

Aim: The aim of the study was to compare vitamin D, triglyceride and cholesterol levels of hepatosteatosis patients with healthy controlpatients.Material and Methods: Ninety-nine patients with hepatosteatosis and healthy control patients were included in our study retrospectively.The patients included in the study were patients who applied to the pediatric gastroenterology outpatient clinic between 2020 and 2023.Results: A total of 99 patients, 47 (47.5%) with hepatosteatosis and 52 (52.5%) in the control group, were included in our study. Mean ALTvalues were 35.2 ± 19.5 and 28.3 ± 13.0 in the hepatosteatosis and control groups, respectively (P= 0.039). Mean triglyceride (136 ± 28 vs125 ± 24; P= 0.042) and cholesterol (165 ± 20 vs 154 ± 20; P= 0.010) levels were higher in the hepatosteatosis group than in the controlgroup and the result was found to be significantly different. Mean vitamin D levels did not differ between the groups. Vitamin D deficiency wasfound to be high in both groups, but no difference was analyzed between the groups (72.3% vs 61.5%; P= 0.491).Conclusion: Triglyceride and cholesterol levels were found to be higher in patients with hepatosteatosis. Fasting blood glucose is higher inthe hepatosteatosis group. Based on these results and the literature, patients with hepatosteatosis pose a risk for important diseases suchas metabolic syndrome and cardiovascular diseases such as atherosclerosis in the following years.

Cholesterol hepatosteatosis triglyceride vitamin D

Kolesterol hepatosteatoz trigliserid D vitamini

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