Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging

Pınar Pelin Özcan; Zehra Pınar Koç; Gökçe Yavan; Mustafa Musa Dirlik

Image Presentation

Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging

Year 2022, Volume: 2 Issue: 1, 12 - 16, 15.04.2022

Pınar Pelin Özcan Zehra Pınar Koç Gökçe Yavan Mustafa Musa Dirlik

Abstract

Von Hippel–Lindau disease (VHL), also known as Von Hippel–Lindau syndrome, is a rare genetic disorder with multisystem involvement (1). Imaging plays an important role in the evaluation of cancer patients. In recent years, much attention has been focused on 68Ga-PSMA PET-CT. We hereby, report the rare case of a Von Hippel Lindau Syndrome with renal cell carcinoma, pancreas cystadenoma, hemangioblastoma and pancreatic NET demonstrated on both Ga-68 PSMA and FDG PET-CT imaging.

Keywords

68 Ga PSMA PET-CT, FDG PET-CT, Von Hippel Lindau Syndrome

References

1. Von Hippel-Lindau disease, Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2018-04-17
2. Lindsay, Kenneth W; Ian Bone; Robin Callander; J. van Gijn (1991). Neurology and Neurosurgery Illustrated. United States: Churchill Livingstone. ISBN 978-0-443-04345-1
3. Frantzen, Carlijn; Links, Thera P.; Giles, Rachel H. (21 June 2012). "Von Hippel-Lindau Syndrome". Von Hippel-Lindau Disease. GeneReviews at NCBI. University of Washington, Seattle. Retrieved 30 March 2013
4. Maher ER; Glenn GM; Walther M; et al. (June 2011). "von Hippel-Lindau disease: a clinical and scientific review". European Journal of Human Genetics. 19 (6): 617–23
5. Friedrich, CA (December 1, 1999). "Von Hippel-Lindau syndrome. A pleomorphic condition". Cancer. 86 (11 Suppl): 2478–82
6. Leung RS, Biswas SV, Duncan M, et al. Imaging features of von Hippel-Lindau disease. Radiographics. 2008; 28:65–67
7. Ambrosini V, Campana D, Allegri V, et al. 68Ga-DOTANOC PET/CT detects somatostatin receptors expression in von Hippel-Lindau cerebellar disease. Clin. Nucl. Med. 2011; 36:64–65.
8. Oh JR, Kulkarni H, Carreras C, et al. Ga-68 Somatostatin Receptor PET/CT in von Hippel-Lindau Disease. Nucl. Med. Mol. Imaging. 2012; 46:129–133
9. Papadakis G.Z., Millo C, Sadowski SM, et. al. Epididymal cystadenomas in von Hippel-Lindau disease showing increased activity on 68Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 October ; 41(10): 781–782
10. Sizdahkhani S, Michael J. Feldman MJ.,Martin G. Piazza MG., et. al. Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target. Scientific Reports | 7:40822 | DOI: 10.1038/srep40822
11. Papadakis G.Z., Millo C, Sadowski SM, et. al. Endolymphatic sac tumor showing increased activity on 68 Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 October; 41(10): 783–784
12. Leung RS, Biswas SV, Duncan M, et al. Imaging features of von Hippel-Lindau disease. Radiographics. 2008; 28:65–67
13. Wood CG, Stromberg LJ, Harmath CB, et al. CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 2015; 35:125–141.
14. Hofman MS, Lau WF, Hicks RJ. Somatostatin Receptor Imaging with 68Ga-DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 2015; 35:500–516
15. Papadakis GZ, Bagci U, Sadowski SM, et al. Ectopic ACTH and CRH co-secreting tumor localized by 68Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2015; 40:576–578
16. Papadakis G.Z., Millo C, Sadowski SM, et. al. Kidney tumor in a von Hippel-Lindau (VHL) patient with intensely increased activity on 68 Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 December; 41(12): 970–971

There are 16 citations in total.

Details

Primary Language	English
Subjects	Oncology and Carcinogenesis
Journal Section	Case Reports
Authors	Pınar Pelin Özcan This is me 0000-0003-0147-2678 Zehra Pınar Koç This is me 0000-0002-3274-5790 Gökçe Yavan This is me 0000-0002-7332-6293 Mustafa Musa Dirlik This is me 0000-0002-5326-2149
Publication Date	April 15, 2022
Published in Issue	Year 2022 Volume: 2 Issue: 1

Cite

APA	Özcan, P. P., Koç, Z. P., Yavan, G., Dirlik, M. M. (2022). Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging, 2(1), 12-16.
AMA	Özcan PP, Koç ZP, Yavan G, Dirlik MM. Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging. April 2022;2(1):12-16.
Chicago	Özcan, Pınar Pelin, Zehra Pınar Koç, Gökçe Yavan, and Mustafa Musa Dirlik. “Von Hippel Lindau Syndrome With Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging”. Molecular Oncologic Imaging 2, no. 1 (April 2022): 12-16.
EndNote	Özcan PP, Koç ZP, Yavan G, Dirlik MM (April 1, 2022) Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging 2 1 12–16.
IEEE	P. P. Özcan, Z. P. Koç, G. Yavan, and M. M. Dirlik, “Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging”, Molecular Oncologic Imaging, vol. 2, no. 1, pp. 12–16, 2022.
ISNAD	Özcan, Pınar Pelin et al. “Von Hippel Lindau Syndrome With Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging”. Molecular Oncologic Imaging 2/1 (April 2022), 12-16.
JAMA	Özcan PP, Koç ZP, Yavan G, Dirlik MM. Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging. 2022;2:12–16.
MLA	Özcan, Pınar Pelin et al. “Von Hippel Lindau Syndrome With Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging”. Molecular Oncologic Imaging, vol. 2, no. 1, 2022, pp. 12-16.
Vancouver	Özcan PP, Koç ZP, Yavan G, Dirlik MM. Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging. 2022;2(1):12-6.