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Bipolar disorder and oxidative stress

Year 2014, , 70 - 9, 08.10.2014

Murat Erdem Süleyman Akarsu Erdal Pan Yasemin Gülcan Kurt

https://doi.org/10.5455/jmood.20131205063815

Abstract

The evidence about the role of oxidative stress on the pathophysiology of bipolar disorder (BD) has been increased recently. It has been considered that oxidative stress and its effects cause damage in the critical brain circuits regulating affective functions, emotions, motor behaviors and so that the symptoms seen in BD occur by the deterioration of mood-stabilizing mechanisms. In clinical trials, significant changes were determined in the BD patients’ levels of antioxidant enzymes, lipid peroxidation and nitric oxide. Because of the different clinical features of the disorder such as manic/hypomanic, depressive, or mixed episode, the data associated with oxidative stress might vary among the patients. Some mood stabilizers used in the treatment are known to have antioxidant effects. Normalization of the oxidative stress parameters had been reported in the treatment process of BD. It makes a positive contribution to the treatment process that these drugs increase the neurotrophic factors and protect against apoptosis as well as reducing the effects of oxidative stress. Reactive oxygen species occur with the escape of some electrons from the chain during their flow in the mitochondria complex and mitochondrial dysfunction develops after the inhibition of electron transport chain. Mitochondrial dysfunction found to be associated with the pathogenesis of BD. Mitochondrial dysfunction and oxidative stress may create symptoms of the BD secondary to the changes in intracellular signaling system, balance of intracellular calcium, and DNA structure. Using antioxidants, in addition to the treatment, is expected to provide positive contribution to the prognosis in bipolar patients. Systematic studies including each period of the disorder are needed for using the findings indicating deterioration of oxidative balance as biological markers in BD.

Keywords

bipolar disorder oxidative stress mood stabilizers

References

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İki uçlu bozukluk ve oksidatif stres

Year 2014, , 70 - 9, 08.10.2014

Murat Erdem Süleyman Akarsu Erdal Pan Yasemin Gülcan Kurt

https://doi.org/10.5455/jmood.20131205063815

Abstract

Son dönemde oksidatif stresin iki uçlu bozukluğun (İUB) fizyopatolojisinde rolü olduğuna dair bulgular artış göstermektedir. Oksidatif stres ve etkilerinin, özellikle mizacı, emosyonları, motor davranışları düzenleyen kritik beyin devrelerinde hasara neden olduğu; böylece İUB’de görülen belirtilerin mizacı düzenleyen mekanizmalarda bozulma ile ortaya çıktığı düşünülmektedir. Klinik çalışmalarda, İUB hastalarında antioksidan enzim, lipid peroksidasyonu ve nitrik oksit düzeylerinde belirgin değişiklikler saptanmıştır. Hastalığın manik/hipomanik, depresif ya da karma dönem gibi farklı klinik görünümleri nedeniyle oksidatif stres ile ilişkili veriler farklılık gösterebilmektedir. Tedavide kullanılan bazı mizaç düzenleyicilerinin antioksidan özellikleri olduğu bilinmektedir. İUB’nin tedavi sürecinde oksidatif parametrelerde normalleşme bildirilmiştir. Bu ilaçların oksidatif stresi azaltıcı etkisi yanı sıra, nörotrofik faktörleri artırması ve hücre ölümüne karşı koruyucu olması, tedavi sürecine olumlu katkı yapmaktadır. Mitokondri kompleksinde elektron akışı sırasında bazı elektronların zincirden kaçması ile reaktif oksijen radikalleri oluşmakta ve elektron transport zincir inhibisyonu ile mitokondrial işlev bozukluğu gelişmektedir. İUB patogenezi ile mitokondrial işlev bozukluğu ilişkili bulunmuştur. Mitokondrial işlev bozukluğu ve oksidatif hasar, hücre içi sinyal sisteminde, hücre içi kalsiyum dengesinde ve DNA yapısında değişiklikler oluşturarak İUB belirtilerine neden olabilir. İUB’de tedaviye ek olarak antioksidan kullanılmasının hastalığın seyrine olumlu katkı sağlayabileceği düşünülmektedir. İUB’de oksidatif dengedeki bozulmayı gösteren bulguların biyolojik belirteç olarak kullanılabilmesi için, sistemli ve bozukluğun her dönemini kapsayacak çalışmalara ihtiyaç vardır.

Keywords

iki uçlu bozukluk oksidatif stres mizaç düzenleyicileri

References

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  • 2. Andreazza AC, Cassini C, Rosa AR, Leite MC, Almeida LMV, Nardin P, Cunha AB, Ceresér KM, Santin A, Gottfried C, Salvador M, Kapczinski F, Gonçalves CA. Serum S100B and antioxidant enzymes in bipolar patients. J Psychiatr Res 2007;41:523-9.
  • 3. Kuloğlu M, Ustundag B, Atmaca M, Canatan H, Tezcan E, Cinkilinc N. Lipid peroxidation and antioxidant enzyme levels in patients with schizophrenia and bipolar disorder. Cell Biochem Funct 2002;20:171-5.
  • 4. Ranjekar PK, Hinge A, Hegde MV, Ghate M, Kale A, Sitasawad S, Wagh UV, Debsikdar VB, Mahadik SP. Decreased antioxidantenzymes and membrane essential polyunsaturated fatty acids in schizophrenicand bipolar mood disorder patients. Psychiatry Res 2003;121:109-22.
  • 5. Steckert AV, Valvassori SS, Moretti M, Dal-Pizzol F, Quevedo J. Role of oxidative stres in the pathophysiology of bipolar disorder. Neurochem Res 2010;35:1295-301.
  • 6. Gergerlioglu HS, Savas HA, Bulbul F, Selek S, Uz E, Yumru M. Changes in nitric oxidelevel and superoxide dismutase activity during antimanic treatment. Prog Neuropsychopharmacol Biol Psychiatry 2007;31:697-702.
  • 7. Machado-Vieira R, Andreazza AC, Viale CI, Zanatto V, Cereser Jr V, Vargas RS, Kapczinski F, Portela LV, Souza DO, Salvador M, Gentil V. Oxidativestress parameters in unmedicated and treated bipolar subjects during initialmanic episode: a possible role for lithium antioxidant effects. Neurosci Lett 2007;421:33-6.
  • 8. Selek S, Savas HA, Gergerlioglu HS, Bulbul F, Uz E, Yumru M. The course of nitric oxideand superoxide dismutase during treatment of bipolar depressive episode. J Affect Disord 2008;107:89-94.
  • 9. Savas HA, Gergerlioglu HS, Armutcu F, Herken H, Yilmaz HR, Kocoglu E, Selek S, Tutkun H, Zoroglu SS, Akyol O. Elevated serum nitric oxide and superoxide dismutase in euthymic bipolar patients: impactof past episodes. World J Biol Psychiatry 2006;7:51-5.
  • 10. Özcan ME, Gulec M, Ozerol E, Polat R, Akyol O. Antioxidant enzyme activities and oxidativestress in affective disorders. Int Clin Psychopharmacol 2004;19:89-95.
  • 11. Berk M, Kapczinskie F, Andreazzae AC, Deana OM, Giorlando F, Maesg M, Yücel M, Gamae CS, Dodda S, Deand B, Magalhãesa PVS, Ammingerb P, McGorryb P, Malhi GS. Pathways underlying neuroprogression in bipolar disorder: Focus on inflammation, oxidative stress and neurotrophic factors. Neuroscience and Biobehavioral Reviews 2011;35:804-17.
  • 12. Zarate CA, Singh J Jr, Manji HK. Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder. Biol Psychiatry 2006;59:1006-20 13. Halliwell B, Gutteridge JMC. Free radicals in biology and medicine. Oxford: Oxford University Press; 2007:440-613.
  • 14. Adam-Vizi V, Chinopoulos C. Bioenergetics and the formation of mitochondrial reactive oxygen species. Trends Pharmacol Sci 2006;27:639-45.
  • 15. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence baseand therapeutic implications. Int J Neuropsychopharmacol 2008;21:1-26.
  • 16. Andreazza AC, Kauer-Sant’anna M, Frey BN Bond DJ, Kapczinski F, Young LT, Yatham LN. Oxidative stress markers in bipolar disorder: a meta-analysis. J Affect Disord 2008;111:135-44.
  • 17. Khairova R,Pawar R, Salvadore G, Juruena MF, De Sousa RT, Soeiro-De-Souza MG, Salvador M, Zarate CA, Gattaz WF, Machado-Vieira R.Effects of lithium on oxidative stress parameters in healthySubjects. Mol Med Report 2012;5:680-2.
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  • 21. Abdalla DSP, Manteiro HP, Oliveira JAC, Bechara CH. Activities of superoxide dismutase and glutathione peroxidase in schizophrenic and manic depressive patients. Clin Chem 1986;32:805-7.
  • 22. Wang JF, Shao L, Sun X, Young LT. Increased oxidative stress in the anterior cingulate cortex of subjects with bipolar disorder and schizophrenia. Bipolar Disord 2009;11:523-9.
  • 23. Yanik M, Vural H, Tutkun H, Zoroglu SS, Savas HA, Herken H, Koçyigit A, Keles H, Akyol O. The role of the arginine nitricoxide pathway in the pathogenesis of bipolar affective disorder.Eur Arch Psychiatry Clin Neurosci 2004;254:43-7.
  • 24. Savas HA, Gergerlioglu HS, Gurel A, Selek S, Savas E,Kocoglu E. Increased xanthine oxidase and malondialdehydelevels in euthymic bipolar patients. Klinik Psikiyatri Dergisi 2005;8:180-5.
  • 25. SavasHA,Herken H, Yurekli M. Possible role of nitricoxide and adrenomedullin in bipolar affective disorder. Neuropsychobiology 2002;45:57-61.
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There are 77 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Murat Erdem This is me

Süleyman Akarsu This is me

Erdal Pan This is me

Yasemin Gülcan Kurt This is me

Publication Date October 8, 2014
Published in Issue Year 2014

Cite

APA Erdem, M., Akarsu, S., Pan, E., Kurt, Y. G. (2014). İki uçlu bozukluk ve oksidatif stres. Journal of Mood Disorders, 4(2), 70-9. https://doi.org/10.5455/jmood.20131205063815
AMA Erdem M, Akarsu S, Pan E, Kurt YG. İki uçlu bozukluk ve oksidatif stres. Journal of Mood Disorders. February 2014;4(2):70-9. doi:10.5455/jmood.20131205063815
Chicago Erdem, Murat, Süleyman Akarsu, Erdal Pan, and Yasemin Gülcan Kurt. “İki uçlu Bozukluk Ve Oksidatif Stres”. Journal of Mood Disorders 4, no. 2 (February 2014): 70-9. https://doi.org/10.5455/jmood.20131205063815.
EndNote Erdem M, Akarsu S, Pan E, Kurt YG (February 1, 2014) İki uçlu bozukluk ve oksidatif stres. Journal of Mood Disorders 4 2 70–9.
IEEE M. Erdem, S. Akarsu, E. Pan, and Y. G. Kurt, “İki uçlu bozukluk ve oksidatif stres”, Journal of Mood Disorders, vol. 4, no. 2, pp. 70–9, 2014, doi: 10.5455/jmood.20131205063815.
ISNAD Erdem, Murat et al. “İki uçlu Bozukluk Ve Oksidatif Stres”. Journal of Mood Disorders 4/2 (February 2014), 70-9. https://doi.org/10.5455/jmood.20131205063815.
JAMA Erdem M, Akarsu S, Pan E, Kurt YG. İki uçlu bozukluk ve oksidatif stres. Journal of Mood Disorders. 2014;4:70–9.
MLA Erdem, Murat et al. “İki uçlu Bozukluk Ve Oksidatif Stres”. Journal of Mood Disorders, vol. 4, no. 2, 2014, pp. 70-9, doi:10.5455/jmood.20131205063815.
Vancouver Erdem M, Akarsu S, Pan E, Kurt YG. İki uçlu bozukluk ve oksidatif stres. Journal of Mood Disorders. 2014;4(2):70-9.