BibTex RIS Cite

Bipolar disorder and congitive functions

Year 2013, Volume: 3 Issue: 5, 0 - 0, 01.05.2013

Abstract

Despite evidence that individuals with bipolar disorder have neurocognitive impairment that persists during euthymia, decline in cognitive functioning during the illnes has not been well established. Several risk factors were reported, such as early onset of illness, prior number of hospitalization, psychotic features, and number of past episods. However there is limited evidence on the relationship between cognitive dsyfunctions and pharmacotherapy and comorbidity. Furthermore, the prognosis of cognitive dysfunction over time is unclear. Cognitive dysfunctions may be an endophontype in bipolar disorder leading disability. Cognitive aspects of bipolar disorder and its treatment if can be investigated via simultanously conducted genetic and imaging studies invaluable information can be obtained on this important matter.

References

  • Şentürk V, Göker C, Bilgiç A, Ölmez Ş, Tuğcu H, Öncü B, Atbaşoğlu E.C. Impaired Verbal Memory And Otherwise Spared Cognition In Remitted Bipolar Patients On Monotherapy With Lithium Or Valproate. Bipolar Disord 2007;9:136-44.
  • Arts B, Jabben N, Krabbendam L, Van Os J. Meta-Analyses Of Cognitive Functioning In Euthymic Bipolar Patients And Their First-Degree Relatives. Psychol Med 2008;38:771-85.
  • Bora E, Yücel M, Pantelis C. Cognitive Endophenotypes Of Bipolar Disorder: A Meta-Analysis Of Neuropsychological Deficits In Euthymic Patients And Their First-Degree Realatives. J Affect Disord 2009;113:1-20.
  • Robinson L.J, Thompson J.M, Gallagher P. ve ark. A Meta-Analysis Of Cognitive Deficits In Euthymic Patients With Bipolar Disorder. J Affect Disord 2006;93:105-15.
  • Torres I.J, Boudreau V.G, Yatham L.N. Neuropsychological Functioning In Euthymic Bipolar Disorder: A Meta-Analysis. Acta Psychiatr Scand 2007;434:17-26.
  • Mann-Wrpbel M.C, Carreno J.T, Dickinson D. Meta-Analysis Of Neuropsychological Functioning In Euthymic Bipolar Disorder: An Update And Investigation Of Moderator Variabiles. Bipolar Disord 2011;13:334-43.
  • Kurtz M.M, Gerraty R.T, A Meta-Analytic Investigation Of Neurocognitive Deficits In Bipolar Illness: Profile And Effects Of Clinical State. Neuropsycohology 2009;23:551-62.
  • Robinson L.J, Ferrier I.N, Evolution Of Cognitive Impairment In Bipolar Disorder: A Systemic Review Of Cross-Sectional Evidence. Bipolar Disord 2006;8:103-16.
  • Thompson J.M, Gallagher P, Hughes J.H. ve ark. Neurocognitive Impairment In Euthymic Patients With Bipolar Disorder. Br J Psychiatry 2005;186:32-40.
  • Bora E, Vahip S, Akdeniz F. ve ark. The Effect Of Previous Psychotic Mood Episodes On Cognitive Impairment In Euthymic Bipolar Patients. Bipolar Disord 2007;9:468-77.
  • Torrent C, Martinez-Aran A, Daban C. ve ark. Cognitive Impairment In Bipolar II Disorder. Br J Psychiatry 2006;189:254-59.
  • Martinez-Aran A, Vieta E., Reinares M. ve ark. Cognitive Functions Across Manic Or Hypomanic, Depressed And Euthymic States In Bipolar Disorder. Am J Psychiatry 2004;161:262-70.
  • Nemeroff C.B. An Ever-Increasing Pharmacopoeia For The Management Of Patients With Bipolar Disorder. J Clin Psychiatry 2000;61:19-25.
  • Stip E, Dufresne J, Lussier I, Yatham L, A Double-Blind, Placebo-Controlled Study Of The Effects Of Lithium On Cognition In Healthy Subjects: Mild And Selective Effects On Learning. J Affect Disord 2000;60:147-57.
  • Savitz J, Solms M, Ramesar R. Neuropsychological Dysfunction In Bipolar Affective Disorder: A Critical Opinion. Bipolar Disord 2005;7:216-35.
  • Zubieta J.K, Huguelet P, O’Neil R.L, Giordani B.J. Cognitive Functions In Eutymic Bipolar I Disorder. Psychiatry Res 2011;102:9-20.
  • Bearden C.E, Glahn D.C, Caetano S. ve ark. Evidence For Disruption In Prefrontal Cortical Functions In Juvenile Bipolar Disorder. Bipolar Disord 2007;9:145-59.
  • Şentürk V, Demirel H, Çakır S, Kesebir S. Atbaşoğlu E.C. Bipolar Bozukluğu Lityum, Valproik Asit Ya Da Atipik Antipsikotik Monoterapisi İle Remisyonda Olan Hastaların Bilişsel İşlevleri. 48. Ulusal Psikiyatri Kongresi 2012, Bursa
  • Balanza-Martinez V, Tabares-Seisdedos R, Selva-Vera G. ve ark. Persistent Cognitive Dysfunctions In Bipolar I Disorder And Schizophrenia Patients: A 3-Year Follow-Up Study. Psychother Psychosom 2005;74:113-9.
  • Mur M, Portella M.J, Martinez-Aran A, Pifarre J, Vieta E. Long-Term Stability Of Cognitive Impairment In Bipolar Disorder: A 2-Year FollowUp Study Of Lithium-Treated Euthymic Bipolar Patients. J Clin Psychiatry 2008;69:712-9.

İki uçlu bozukluk ve bilişsel işlevler

Year 2013, Volume: 3 Issue: 5, 0 - 0, 01.05.2013

Abstract

İki uçlu bozuklukta ötimik dönemde de bilişsel işlevlerde bozulmaya dair bulgular bildirilmektedir. Yürütücü işlevler, dikkat ve bellek bilişsel işlevlerin sıklıkla bozulduğu alanları oluşturuken bu bozulmaya neden olarak hastalığın erken yaşta başlaması, hastaneye yatış sayısının çokluğu, psikotik içeriğin olması, atak sayısının çok olması gibi klinik nedenler sayılmaktadır. Ancak bilişsel işlevlerle farmakoterapinin ilişkisi, ekhastalıkların bilişsel işlevler üzerindeki etkisi ve bilişsel işlevlerin seyrine ilişkin çok az sayıda çalışma bulunmaktadır. Bilişsel işlev bozukluğunun iki uçlu bozukluğa ait endofenotip olma olasılığının yüksek olması ve bilişsel işlev bozukluğunun yetiyitimi ile ilişkilendirilmesi konunun önemini vurgulamaktadır. Bilişsel işlevlerle birlikte görüntüleme çalışmalarının ve genetik incelemelerin yapılması ve izlem çalışmalarının yürütülmesi bu konudaki bilgilerimize önemli katkılar sağlayabilir.

References

  • Şentürk V, Göker C, Bilgiç A, Ölmez Ş, Tuğcu H, Öncü B, Atbaşoğlu E.C. Impaired Verbal Memory And Otherwise Spared Cognition In Remitted Bipolar Patients On Monotherapy With Lithium Or Valproate. Bipolar Disord 2007;9:136-44.
  • Arts B, Jabben N, Krabbendam L, Van Os J. Meta-Analyses Of Cognitive Functioning In Euthymic Bipolar Patients And Their First-Degree Relatives. Psychol Med 2008;38:771-85.
  • Bora E, Yücel M, Pantelis C. Cognitive Endophenotypes Of Bipolar Disorder: A Meta-Analysis Of Neuropsychological Deficits In Euthymic Patients And Their First-Degree Realatives. J Affect Disord 2009;113:1-20.
  • Robinson L.J, Thompson J.M, Gallagher P. ve ark. A Meta-Analysis Of Cognitive Deficits In Euthymic Patients With Bipolar Disorder. J Affect Disord 2006;93:105-15.
  • Torres I.J, Boudreau V.G, Yatham L.N. Neuropsychological Functioning In Euthymic Bipolar Disorder: A Meta-Analysis. Acta Psychiatr Scand 2007;434:17-26.
  • Mann-Wrpbel M.C, Carreno J.T, Dickinson D. Meta-Analysis Of Neuropsychological Functioning In Euthymic Bipolar Disorder: An Update And Investigation Of Moderator Variabiles. Bipolar Disord 2011;13:334-43.
  • Kurtz M.M, Gerraty R.T, A Meta-Analytic Investigation Of Neurocognitive Deficits In Bipolar Illness: Profile And Effects Of Clinical State. Neuropsycohology 2009;23:551-62.
  • Robinson L.J, Ferrier I.N, Evolution Of Cognitive Impairment In Bipolar Disorder: A Systemic Review Of Cross-Sectional Evidence. Bipolar Disord 2006;8:103-16.
  • Thompson J.M, Gallagher P, Hughes J.H. ve ark. Neurocognitive Impairment In Euthymic Patients With Bipolar Disorder. Br J Psychiatry 2005;186:32-40.
  • Bora E, Vahip S, Akdeniz F. ve ark. The Effect Of Previous Psychotic Mood Episodes On Cognitive Impairment In Euthymic Bipolar Patients. Bipolar Disord 2007;9:468-77.
  • Torrent C, Martinez-Aran A, Daban C. ve ark. Cognitive Impairment In Bipolar II Disorder. Br J Psychiatry 2006;189:254-59.
  • Martinez-Aran A, Vieta E., Reinares M. ve ark. Cognitive Functions Across Manic Or Hypomanic, Depressed And Euthymic States In Bipolar Disorder. Am J Psychiatry 2004;161:262-70.
  • Nemeroff C.B. An Ever-Increasing Pharmacopoeia For The Management Of Patients With Bipolar Disorder. J Clin Psychiatry 2000;61:19-25.
  • Stip E, Dufresne J, Lussier I, Yatham L, A Double-Blind, Placebo-Controlled Study Of The Effects Of Lithium On Cognition In Healthy Subjects: Mild And Selective Effects On Learning. J Affect Disord 2000;60:147-57.
  • Savitz J, Solms M, Ramesar R. Neuropsychological Dysfunction In Bipolar Affective Disorder: A Critical Opinion. Bipolar Disord 2005;7:216-35.
  • Zubieta J.K, Huguelet P, O’Neil R.L, Giordani B.J. Cognitive Functions In Eutymic Bipolar I Disorder. Psychiatry Res 2011;102:9-20.
  • Bearden C.E, Glahn D.C, Caetano S. ve ark. Evidence For Disruption In Prefrontal Cortical Functions In Juvenile Bipolar Disorder. Bipolar Disord 2007;9:145-59.
  • Şentürk V, Demirel H, Çakır S, Kesebir S. Atbaşoğlu E.C. Bipolar Bozukluğu Lityum, Valproik Asit Ya Da Atipik Antipsikotik Monoterapisi İle Remisyonda Olan Hastaların Bilişsel İşlevleri. 48. Ulusal Psikiyatri Kongresi 2012, Bursa
  • Balanza-Martinez V, Tabares-Seisdedos R, Selva-Vera G. ve ark. Persistent Cognitive Dysfunctions In Bipolar I Disorder And Schizophrenia Patients: A 3-Year Follow-Up Study. Psychother Psychosom 2005;74:113-9.
  • Mur M, Portella M.J, Martinez-Aran A, Pifarre J, Vieta E. Long-Term Stability Of Cognitive Impairment In Bipolar Disorder: A 2-Year FollowUp Study Of Lithium-Treated Euthymic Bipolar Patients. J Clin Psychiatry 2008;69:712-9.
There are 20 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Vesile Şentürk Cankorur This is me

Publication Date May 1, 2013
Published in Issue Year 2013 Volume: 3 Issue: 5

Cite

APA Cankorur, V. Ş. (2013). İki uçlu bozukluk ve bilişsel işlevler. Journal of Mood Disorders, 3(5).
AMA Cankorur VŞ. İki uçlu bozukluk ve bilişsel işlevler. Journal of Mood Disorders. May 2013;3(5).
Chicago Cankorur, Vesile Şentürk. “İki uçlu Bozukluk Ve bilişsel işlevler”. Journal of Mood Disorders 3, no. 5 (May 2013).
EndNote Cankorur VŞ (May 1, 2013) İki uçlu bozukluk ve bilişsel işlevler. Journal of Mood Disorders 3 5
IEEE V. Ş. Cankorur, “İki uçlu bozukluk ve bilişsel işlevler”, Journal of Mood Disorders, vol. 3, no. 5, 2013.
ISNAD Cankorur, Vesile Şentürk. “İki uçlu Bozukluk Ve bilişsel işlevler”. Journal of Mood Disorders 3/5 (May 2013).
JAMA Cankorur VŞ. İki uçlu bozukluk ve bilişsel işlevler. Journal of Mood Disorders. 2013;3.
MLA Cankorur, Vesile Şentürk. “İki uçlu Bozukluk Ve bilişsel işlevler”. Journal of Mood Disorders, vol. 3, no. 5, 2013.
Vancouver Cankorur VŞ. İki uçlu bozukluk ve bilişsel işlevler. Journal of Mood Disorders. 2013;3(5).