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Examination of echocardiographic parameters for the early diagnosis of cardiac dysfunction in beta thalassemia major patients

Year 2014, Volume: 1 Issue: 2, 35 - 43, 01.06.2014

Aysen Turedi Yildirim Yesim Oymak Yontem Yaman Timur Mese Selen Bayraktaroglu Yesim Aydinok Canan Vergin

Abstract

Objective: This study aimed to determine the utility of tissue Doppler, pulse-wave Doppler, and conventional echocardiography for the detection of cardiac dysfunction in the early period in beta thalassemia patients. Methods: Forty beta thalassemia major patients undergoing regular blood transfusion and chelation therapy and 30 healthy controls with similar demographic factors were included in the study. Both the patient and control groups were examined with, tissue Doppler, pulse-wave Doppler, motion-mode echocardiography. Ferritin values and T2* magnetic resonance measurements were recorded for those in the patient group. Results: Diastolic dysfunction indicators like early ventricular filling rate, atrial contraction rate, mitral A wave time, and reverse pulmonary venous flow velocity were higher in the patient group (p

Keywords

Beta thalassemia major cardiac dysfunction pulse-wave Doppler echocardiography tissue Doppler echocardiography conventional echocardiography T2* magnetic resonance

References

  • Hirota Y. A clinical study of left ventricular relaxation. Circulation. 1980;62(4):756-63.
  • Spirito P, Lupi G, Melevendi C, Vecchio C. Restrictive diastolic echocardiography in patients with thalassemia major. Circulation. 1990;82(1):88-94. by Doppler
  • Parale GP, Pawar SS, Tapare VS. Assessment of LV diastolic function in patients with beta-thalassemia major with special reference to E/Eann ratio. Journal of pediatric hematology/oncology. 2009;31(1):69-73.
  • Ho CY. Echocardiographic Assessment of Diastolic Solomon Function. Echocardiography: A Practical Handbook with DVD. New Jersey: Humana Press Inc. 2007:119-131. SD editor. Essential
  • Kremastinos DT, Tsiapras DP, Tsetsos GA, Rentoukas EI, Vretou HP, Toutouzas PK. Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Circulation. 1993;88(3):1127-35.
  • Tei C, Ling LH, Hodge DO, Bailey KR, Oh JK, Rodeheffer RJ, et al. New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function--a study in normals and dilated cardiomyopathy. Journal of cardiology. 1995;26(6):357-66.
  • Ucar T, Ileri T, Atalay S, Uysal Z, Tutar E, Ertem M. Early detection of myocardial dysfunction in children with beta-thalassaemia major. The international journal of cardiovascular imaging. 2009;25(4):379-86.
  • Feigenbaum H. Role of M-mode technique in today's echocardiography. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2010;23(3):240-57; 335-7.
  • Stakos DA, Margaritis D, Tziakas DN, Kotsianidis I, Chalikias GK, Tsatalas K, et al. Cardiovascular involvement in patients with beta-thalassemia major without cardiac iron overload. International journal of cardiology. 2009;134(2):207-11.
  • Tokgöz H, Çalışkan Ü. Talasemi demir regülasyonu, metabolizması ve demir yükünün tayini. Türkiye Klinikleri J Hem Onc-Special Topics. 2010;3:70-75.
  • Ashena Z, Ghafurian S, Ehsani MA. The relation between left ventricular diastolic indices and serum ferritin in thalassemia major. Pediatric hematology and oncology. 2007;24(1):3-14.
  • Fischer R, Harmatz PR. Non-invasive assessment of tissue iron overload. Hematology / the Education Program of the American Society of Hematology American Society of Hematology Education Program. 2009:215-21.
  • Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, Patel J, et al. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009;120(20):1961-8.
  • Aypar E, Alehan D, Hazirolan T, Gumruk F. The efficacy of tissue Doppler imaging in predicting myocardial iron load in patients with beta-thalassemia major: correlation with T2* cardiovascular magnetic resonance. The international journal of cardiovascular imaging. 2010;26(4):413-21.
  • Vogel M, Anderson LJ, Holden S, Deanfield JE, Pennell DJ, Walker JM. Tissue Doppler echocardiography in patients with thalassaemia detects early myocardial dysfunction related to myocardial iron overload. European heart journal. 2003;24(1):113-9.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.

Examination of echocardiographic parameters for the early diagnosis of cardiac dysfunction in beta thalassemia major patients

Year 2014, Volume: 1 Issue: 2, 35 - 43, 01.06.2014

Aysen Turedi Yildirim Yesim Oymak Yontem Yaman Timur Mese Selen Bayraktaroglu Yesim Aydinok Canan Vergin

Abstract

References

  • Hirota Y. A clinical study of left ventricular relaxation. Circulation. 1980;62(4):756-63.
  • Spirito P, Lupi G, Melevendi C, Vecchio C. Restrictive diastolic echocardiography in patients with thalassemia major. Circulation. 1990;82(1):88-94. by Doppler
  • Parale GP, Pawar SS, Tapare VS. Assessment of LV diastolic function in patients with beta-thalassemia major with special reference to E/Eann ratio. Journal of pediatric hematology/oncology. 2009;31(1):69-73.
  • Ho CY. Echocardiographic Assessment of Diastolic Solomon Function. Echocardiography: A Practical Handbook with DVD. New Jersey: Humana Press Inc. 2007:119-131. SD editor. Essential
  • Kremastinos DT, Tsiapras DP, Tsetsos GA, Rentoukas EI, Vretou HP, Toutouzas PK. Left ventricular diastolic Doppler characteristics in beta-thalassemia major. Circulation. 1993;88(3):1127-35.
  • Tei C, Ling LH, Hodge DO, Bailey KR, Oh JK, Rodeheffer RJ, et al. New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function--a study in normals and dilated cardiomyopathy. Journal of cardiology. 1995;26(6):357-66.
  • Ucar T, Ileri T, Atalay S, Uysal Z, Tutar E, Ertem M. Early detection of myocardial dysfunction in children with beta-thalassaemia major. The international journal of cardiovascular imaging. 2009;25(4):379-86.
  • Feigenbaum H. Role of M-mode technique in today's echocardiography. Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography. 2010;23(3):240-57; 335-7.
  • Stakos DA, Margaritis D, Tziakas DN, Kotsianidis I, Chalikias GK, Tsatalas K, et al. Cardiovascular involvement in patients with beta-thalassemia major without cardiac iron overload. International journal of cardiology. 2009;134(2):207-11.
  • Tokgöz H, Çalışkan Ü. Talasemi demir regülasyonu, metabolizması ve demir yükünün tayini. Türkiye Klinikleri J Hem Onc-Special Topics. 2010;3:70-75.
  • Ashena Z, Ghafurian S, Ehsani MA. The relation between left ventricular diastolic indices and serum ferritin in thalassemia major. Pediatric hematology and oncology. 2007;24(1):3-14.
  • Fischer R, Harmatz PR. Non-invasive assessment of tissue iron overload. Hematology / the Education Program of the American Society of Hematology American Society of Hematology Education Program. 2009:215-21.
  • Kirk P, Roughton M, Porter JB, Walker JM, Tanner MA, Patel J, et al. Cardiac T2* magnetic resonance for prediction of cardiac complications in thalassemia major. Circulation. 2009;120(20):1961-8.
  • Aypar E, Alehan D, Hazirolan T, Gumruk F. The efficacy of tissue Doppler imaging in predicting myocardial iron load in patients with beta-thalassemia major: correlation with T2* cardiovascular magnetic resonance. The international journal of cardiovascular imaging. 2010;26(4):413-21.
  • Vogel M, Anderson LJ, Holden S, Deanfield JE, Pennell DJ, Walker JM. Tissue Doppler echocardiography in patients with thalassaemia detects early myocardial dysfunction related to myocardial iron overload. European heart journal. 2003;24(1):113-9.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.
There are 18 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Aysen Turedi Yildirim This is me

Yesim Oymak This is me

Yontem Yaman This is me

Timur Mese This is me

Selen Bayraktaroglu This is me

Yesim Aydinok This is me

Canan Vergin This is me

Publication Date June 1, 2014
Published in Issue Year 2014 Volume: 1 Issue: 2

Cite

APA Yildirim, A. T., Oymak, Y., Yaman, Y., Mese, T., et al. (2014). Examination of echocardiographic parameters for the early diagnosis of cardiac dysfunction in beta thalassemia major patients. Medical Science and Discovery, 1(2), 35-43. https://doi.org/10.17546/msd.68956
AMA Yildirim AT, Oymak Y, Yaman Y, Mese T, Bayraktaroglu S, Aydinok Y, Vergin C. Examination of echocardiographic parameters for the early diagnosis of cardiac dysfunction in beta thalassemia major patients. Med Sci Discov. June 2014;1(2):35-43. doi:10.17546/msd.68956
Chicago Yildirim, Aysen Turedi, Yesim Oymak, Yontem Yaman, Timur Mese, Selen Bayraktaroglu, Yesim Aydinok, and Canan Vergin. “Examination of Echocardiographic Parameters for the Early Diagnosis of Cardiac Dysfunction in Beta Thalassemia Major Patients”. Medical Science and Discovery 1, no. 2 (June 2014): 35-43. https://doi.org/10.17546/msd.68956.
EndNote Yildirim AT, Oymak Y, Yaman Y, Mese T, Bayraktaroglu S, Aydinok Y, Vergin C (June 1, 2014) Examination of echocardiographic parameters for the early diagnosis of cardiac dysfunction in beta thalassemia major patients. Medical Science and Discovery 1 2 35–43.
IEEE A. T. Yildirim, Y. Oymak, Y. Yaman, T. Mese, S. Bayraktaroglu, Y. Aydinok, and C. Vergin, “Examination of echocardiographic parameters for the early diagnosis of cardiac dysfunction in beta thalassemia major patients”, Med Sci Discov, vol. 1, no. 2, pp. 35–43, 2014, doi: 10.17546/msd.68956.
ISNAD Yildirim, Aysen Turedi et al. “Examination of Echocardiographic Parameters for the Early Diagnosis of Cardiac Dysfunction in Beta Thalassemia Major Patients”. Medical Science and Discovery 1/2 (June 2014), 35-43. https://doi.org/10.17546/msd.68956.
JAMA Yildirim AT, Oymak Y, Yaman Y, Mese T, Bayraktaroglu S, Aydinok Y, Vergin C. Examination of echocardiographic parameters for the early diagnosis of cardiac dysfunction in beta thalassemia major patients. Med Sci Discov. 2014;1:35–43.
MLA Yildirim, Aysen Turedi et al. “Examination of Echocardiographic Parameters for the Early Diagnosis of Cardiac Dysfunction in Beta Thalassemia Major Patients”. Medical Science and Discovery, vol. 1, no. 2, 2014, pp. 35-43, doi:10.17546/msd.68956.
Vancouver Yildirim AT, Oymak Y, Yaman Y, Mese T, Bayraktaroglu S, Aydinok Y, Vergin C. Examination of echocardiographic parameters for the early diagnosis of cardiac dysfunction in beta thalassemia major patients. Med Sci Discov. 2014;1(2):35-43.
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