Aldehyde dehydrogenase-1 expression and prognosis in triple-negative breast cancer

Year 2014, Volume: 1 Issue: 2, 44 - 50, 01.06.2014

Edvin Murrja Zeynep Hande Turna Mehmet Akif Ozturk Ahmet Cinkaya Tulin Ozturk

Abstract

Objective: Understanding of other biological characteristics of Triple-negative breast cancer, the development of new therapeutical approaches and identification of new markers is necessary due to the lack of biological markers like ER, PR and HER2. The purpose of this study was to investigate the prognostic effect of the expression of aldehyde dehydrogenase-1 (ALDH1) in TNBC and its relationship with the clinico-pathological features Methods: In this study 87 patient files were searched for clinico-pathological data obtained from the files and paraffin blocks. The prognostic value of these clinical data and ALDH1 positivity were evaluated by determining disease-free survival. Results: TNM stage I vs III (p=0.03), vascular invasion (p=0.05), chemotherapy indication (p=0.02) were significantly associated with DFS. Multivariable analyses didn't demonstrate any statistically significant relationship between ALDH1 (p=0.61) and DFS. Conclusions: We didn\'t find any statistically significant relationship between ALDH1 positivity and DFS. There was no correlation between ALDH1 expression and tumor\'s pathological features .

Keywords

aldehyde dehydrogenase 1, immunohistochemistry, triple-negative breast cancer

Aldehyde dehydrogenase-1 expression and prognosis in triple-negative breast cancer

Abstract

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