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Histopathological Review of Male Breast Cancer Cases

Year 2014, Volume: 1 Issue: 3, 76 - 79, 01.09.2014

Abstract

Objective: Male breast cancer (MBC) accounts for less than 1% of all breast cancer diagnoses and all cancer cases in men. Methods: We included 33 MBC cases and analyzed histopathological features and survival data. Results: The mean age was 63.5, mean tumor diameter was 3 cm. Central quadrants (69.2%) was most common localization, invasive ductal carcinoma (75.8%) was most common histological subtype. Most of the cases (78.6%) were grade 2. Nipple involvement was noted in 9, tumor necrosis in 9, perineural invasion in 15, dermal lymphatic emboli in 10 cases. Nearly half of the cases (45.5%) showed lymph node metastasis. There was statistically significant relation between lymph node metastasis and stromal lymphocyte response, tumor necrosis (p=0.008, p=0.013) also between grade and dermal lymphatic emboli (p=0.04). Non-tumoral parenchymal findings were columnar cell lesions (CCL), (n: 5) and gynaecomastia (n: 3). Majority of the cases showed estrogen receptor (90.9%) and progesterone receptor (77.2%) positivity. Overall survival analysis showed significant results between grade (p=0.008), lymph node metastasis (p=0.03), dermal lymphatic tumor emboli (p=0.02), nipple involvement (p=0.02) and survival. Conclusions: Our results showed good correlation with literature data in terms of histopathological features and prognostic factors. Confidential data about etiological and prognostic factors will be collected through these reports showing institutional experiences. The significance of CCL in MBC etiology, the impact of intratumoral stromal lymphocyte response, hormone receptor-HER2 status on survival should be clarified in larger series

References

  • Agrawal A, Ayantunde AA, Rampaul R, Robertson JF. Male breast cancer: a review of clinical management. Breast cancer research and treatment. 2007;103(1):11-21.
  • Ni YB, Mujtaba S, Shao MM, Lacambra M, Tsang JY, Chan SK, et al. Columnar cell-like changes in the male breast. Journal of clinical pathology. 2014;67(1):45-8.
  • Verschuur-Maes AH, Kornegoor R, de Bruin PC, Oudejans JJ, van Diest PJ. Do columnar cell lesions exist in the male breast? Histopathology. 2014;64(6):818-25.
  • Nahleh Z, Girnius S. Male breast cancer: a gender issue. Nature clinical practice Oncology. 2006;3(8):428-37.
  • Hill TD, Khamis HJ, Tyczynski JE, Berkel HJ. Comparison of male and female breast cancer incidence trends, tumor characteristics, and survival. Annals of epidemiology. 2005;15(10):773-80.
  • Rathore AS, Kumar S, Konwar R, Srivastava AN, Makker A, Goel MM. Presence of CD3+ tumor infiltrating lymphocytes is significantly associated with good prognosis in infiltrating ductal carcinoma of breast. Indian journal of cancer. 2013;50(3):239-44.
  • Giordano SH. A review of the diagnosis and management of male breast cancer. The oncologist. 2005;10(7):471-9
  • Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma. Canadian journal of surgery Journal canadien de chirurgie. 2002;45(4):296-302.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.

Histopathological Review of Male Breast Cancer Cases

Year 2014, Volume: 1 Issue: 3, 76 - 79, 01.09.2014

Abstract

References

  • Agrawal A, Ayantunde AA, Rampaul R, Robertson JF. Male breast cancer: a review of clinical management. Breast cancer research and treatment. 2007;103(1):11-21.
  • Ni YB, Mujtaba S, Shao MM, Lacambra M, Tsang JY, Chan SK, et al. Columnar cell-like changes in the male breast. Journal of clinical pathology. 2014;67(1):45-8.
  • Verschuur-Maes AH, Kornegoor R, de Bruin PC, Oudejans JJ, van Diest PJ. Do columnar cell lesions exist in the male breast? Histopathology. 2014;64(6):818-25.
  • Nahleh Z, Girnius S. Male breast cancer: a gender issue. Nature clinical practice Oncology. 2006;3(8):428-37.
  • Hill TD, Khamis HJ, Tyczynski JE, Berkel HJ. Comparison of male and female breast cancer incidence trends, tumor characteristics, and survival. Annals of epidemiology. 2005;15(10):773-80.
  • Rathore AS, Kumar S, Konwar R, Srivastava AN, Makker A, Goel MM. Presence of CD3+ tumor infiltrating lymphocytes is significantly associated with good prognosis in infiltrating ductal carcinoma of breast. Indian journal of cancer. 2013;50(3):239-44.
  • Giordano SH. A review of the diagnosis and management of male breast cancer. The oncologist. 2005;10(7):471-9
  • Meguerditchian AN, Falardeau M, Martin G. Male breast carcinoma. Canadian journal of surgery Journal canadien de chirurgie. 2002;45(4):296-302.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.
There are 11 citations in total.

Details

Primary Language English
Journal Section Research Article
Authors

Emel Ebru Pala This is me

Zubeyde Yildirim This is me

Ulku Kucuk This is me

Ebru Cakir This is me

Nilay Senkorkmaz This is me

Umit Bayol This is me

Publication Date September 1, 2014
Published in Issue Year 2014 Volume: 1 Issue: 3

Cite

APA Pala, E. E., Yildirim, Z., Kucuk, U., Cakir, E., et al. (2014). Histopathological Review of Male Breast Cancer Cases. Medical Science and Discovery, 1(3), 76-79. https://doi.org/10.17546/msd.63883
AMA Pala EE, Yildirim Z, Kucuk U, Cakir E, Senkorkmaz N, Bayol U. Histopathological Review of Male Breast Cancer Cases. Med Sci Discov. September 2014;1(3):76-79. doi:10.17546/msd.63883
Chicago Pala, Emel Ebru, Zubeyde Yildirim, Ulku Kucuk, Ebru Cakir, Nilay Senkorkmaz, and Umit Bayol. “Histopathological Review of Male Breast Cancer Cases”. Medical Science and Discovery 1, no. 3 (September 2014): 76-79. https://doi.org/10.17546/msd.63883.
EndNote Pala EE, Yildirim Z, Kucuk U, Cakir E, Senkorkmaz N, Bayol U (September 1, 2014) Histopathological Review of Male Breast Cancer Cases. Medical Science and Discovery 1 3 76–79.
IEEE E. E. Pala, Z. Yildirim, U. Kucuk, E. Cakir, N. Senkorkmaz, and U. Bayol, “Histopathological Review of Male Breast Cancer Cases”, Med Sci Discov, vol. 1, no. 3, pp. 76–79, 2014, doi: 10.17546/msd.63883.
ISNAD Pala, Emel Ebru et al. “Histopathological Review of Male Breast Cancer Cases”. Medical Science and Discovery 1/3 (September 2014), 76-79. https://doi.org/10.17546/msd.63883.
JAMA Pala EE, Yildirim Z, Kucuk U, Cakir E, Senkorkmaz N, Bayol U. Histopathological Review of Male Breast Cancer Cases. Med Sci Discov. 2014;1:76–79.
MLA Pala, Emel Ebru et al. “Histopathological Review of Male Breast Cancer Cases”. Medical Science and Discovery, vol. 1, no. 3, 2014, pp. 76-79, doi:10.17546/msd.63883.
Vancouver Pala EE, Yildirim Z, Kucuk U, Cakir E, Senkorkmaz N, Bayol U. Histopathological Review of Male Breast Cancer Cases. Med Sci Discov. 2014;1(3):76-9.