Abstract
Objective: Sepsis is a complex pathophysiological process that involves both alterations in the microcirculation and changes in the biochemical and physiological characteristics of the blood constituents and hyperdynamic syndrome characterized by maldistribution of blood flow. Plasma viscosity is a major determinant of capillary blood flow through the microcirculation. β-glucan is accepted to be one of the most powerful immune response modifiers. The aim of this study was to investigate the possible protective effect of β-glucan on the levels of plasma viscosity and malondialdehyde (MDA), after rats was exposed to sepsis.
Methods: Sepsis was induced by cecal ligation and perforation (CLP) in 14 male Wistar albino rat. To evaluate this, rats were divided into four groups as sham operated, β-glucan treated sham operated, CLP and β-glucan treated CLP. Sixteen hours after operation, rats were decapitated and MDA, plasma viscosity levels were measured.
Results: Plasma viscosity represented, 1.30±0.12 mPa.s in CLP group and 1.35±0.09 mPa.s in CLP+β-glucan group. In the CLP group, MDA levels were found to be higher than in control group. When CLP group compared with CLP+β-glucan group, no significant statistical differences were observed in the levels of plasma viscosity and MDA.
Conclusion: Our results seem that the given dose of β-glucan was probably insufficient to prevent sepsis induced plasma viscosity.
Keywords
References
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- and erythrocyte aggregation in nine mammalian
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- Lazarova M, Labaj J, Eckl P, Kogan G, Slamenova D.
- Effects of dietary intake of a fungal beta-D-glucan
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- Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
- License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
- provided the original work is properly cited.
Abstract
References
- Mihara M, Uchiyama M. Determination of
- malonaldehyde precursor in tissues by thiobarbituric
- acid test. Analytical biochemistry. 1978;86(1):271-8. 17.
- Harkness J. A new instrument for the measurement of
- plasma-viscosity. Lancet. 1963;2(7302):280-1. 18.
- Baskurt OK, Boynard M, Cokelet GC, Connes P, Cooke
- BM, Forconi S, et al. New guidelines for
- hemorheological laboratory techniques. Clinical
- Windberger U, Bartholovitsch A, Plasenzotti R, Korak
- KJ, Heinze G. Whole blood viscosity, plasma viscosity
- and erythrocyte aggregation in nine mammalian
- species: reference values and comparison of data.
- Lazarova M, Labaj J, Eckl P, Kogan G, Slamenova D.
- Effects of dietary intake of a fungal beta-D-glucan
- derivative on the level of DNA damage induced in
- primary rat hepatocytes by various carcinogens.
- Nutrition and cancer. 2006;56(1):113-22.
- Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
- License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
- provided the original work is properly cited.
Details
| Primary Language | English |
|---|---|
| Journal Section | Research Article |
| Authors | |
| Publication Date | January 10, 2015 |
| Published in Issue | Year 2015 Volume: 2 Issue: 1 |
