Pemfigus tedavisinde rituksimabın ötesi: Kimerik otoantikor reseptör T hücre (CAAR-T hücre) tedavisi

Year 2023, Volume: 6 Issue: 1, 1 - 9, 31.01.2023

Hande Ermiş Akkuş

https://doi.org/10.33204/mucosa.1235968

Abstract

Pemfigus vulgaris, nadir görülen, hayatı tehdit eden bir otoimmün büllöz hastalıktır. Hastalığı kontrol etmek için uzun yıllar sistemik kortikosteroid ve adjuvan immünsüpresiflerin kullanılmasının ardından, randomize kontrollü çalışmalarla rituksimabın hastalıktaki etkinliği gösterildi. Böylece rituksimab en güncel Avrupa S2K kılavuzunda hafif ve orta-şiddetli pemfigus vulgarisin ilk sıra tedavi seçeneği olarak yerini aldı. Rituksimab ile her ne kadar umut verici yanıtlar elde edilse de, henüz hastalığa spesifik bir tedavi bulunmamaktadır. Bu bağlamda, en son teknoloji kullanılarak yapılan kimerik otoantikor reseptör tedavisi (CAAR-T hücre tedavisi) tüm ilgiyi üzerine toplamıştır.

Keywords

pemfigus, kimerik otoantikor reseptör tedavisi, hücresel immünoterapi, CAAR-T hücre tedavisi

Supporting Institution

bulunmuyor

Project Number

bulunmuyor

Treatment of pemphigus beyond rituximab: chimeric autoantibody receptor T cell (CAAR-T cell) therapy

Abstract

Pemphigus vulgaris is a rare, life-threatening, autoimmune bullous disease. After decades of systemic corticosteroids and corticosteroid-sparing immunosuppressants being used to control the disease, the efficacy of rituximab has been shown in randomized controlled studies. Hence rituximab constitutes the first-line treatment for mild and moderate-to-severe pemphigus vulgaris according to the most recent European S2K guideline. Despite promising results with rituximab, there is still no disease-specific treatment available. In that regard, chimeric autoantibody receptor therapy (CAAR-T cell therapy) is under the spotlight utilizing a cutting-edge technology.

Keywords

CAAR-T cell therapy, pemphigus, chimeric autoantibody receptor therapy, cellular immunotherapy

Project Number

bulunmuyor

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