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The Effects of Preoperative Clinical and Radiological Results on the Prognosis in Patients Diagnosed with Oligodendroglioma

Year 2017, Volume: 4 Issue: 2, 1 - 5, 01.08.2017

Abstract

Oligodendroglial
tumors are the third most common primary glial originated intracranial tumors.
According to the World Health Organization central nervous system
histopathological classification, Oligodendrogliomas are classified as Grade II
(classic) or Grade III (anaplastic). The aim of this study is to
retrospectively analyze the risk factors of recurrence during the follow- up
period of the patients who were diagnosed with Oligodendroglioma Grade II or
Grade III in our clinic. This study includes 18 patients who have been operated
in Dokuz Eylül University Medical Faculty Department of Neurosurgery between
2008 and 2013 with pathology results compatible with Grade II or Grade III
Oligodendroglioma. The study consisted of 12 males (66.7%) and 6 females (33.3%).
The average age of the patients was 45.22±11.41 (Age range: 26-65). 6 patients
(33.3%) were diagnosed with Oligodendroglioma (WHO Grade II), 12 (66.7%) with
Anaplastic Oligodendroglioma (WHO Grade III). When the subgroups, which were
divided into WHO Grade 2 and 3 by histopathological results, were compared
according to the radiological results, a significant statistical difference has
not been determined between calcification (p=0.596), midline shift (p=0,393),
tumor location (p=0.193), and death rate (0.193).  In the future bioindicators and molecular
studies will be used in the diagnosis and follow up of tumors and the risk
factors that cause recurrence will be defined in more details.

References

  • 1. Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014;16(Suppl 4):1–63.
  • 2. Aldape K, Nejad R, Louis DN, Zadeh G.Integrating molecular markers into the World Health Organization classification of CNS tumors: a survey of the neuro-oncology community. Neuro Oncol. 2017;19(3):336-344.
  • 3. Louis DN, Perry A, Reifenberger G et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803-20.
  • 4. Wesseling P, van den Bent M, Perry A. Oligodendroglioma: pathology, molecular mechanisms and markers.. Acta Neuropathol. 2015;129(6):809-27.
  • 5. Ino Y, Betensky RA, Zlatescu MC, et al. Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. Clin Cancer Res 2001;7: 839–45.
  • 6. Olson JD, Riedel E, DeAngelis LM. Long-term outcome of low-grade oligodendroglioma and mixed glioma. Neurology. 2000;54(7):1442–8.
  • 7. Lebrun C, Fontaine D, Ramaioli A et al. Long-term outcome of oligodendrogliomas. Neurology. 2004;62(10), 1783–7.
  • 8. Smits M. Imaging of oligodendroglioma. Br J Radiol. 2016;89(1060):20150857.
  • 9. Wessels PH, Weber WE, Raven G, et al. Supratentorial grade II astrocytoma: biological features and clinical course. Lancet Neurol 2003;2(7):395–403.
  • 10. Van Den Bent MJ, Bromberg JE, Buckner J. Low-grade and anaplastic oligodendroglioma.. Handb Clin Neurol. 2016;134:361-80.
  • 11. Oktar N, Biray C. Moleküler Tedavide Hedefteki İlk Tümör: Oligodendrogliomlar Türk Nöroşirürji Dergisi. 2005;15(2):130-5. 12. Olson JD, Riedel E, DeAngelis LM. Long-term outcome of low-grade oligodendroglioma and mixed glioma. Neurology. 2000;54(7):1442–8.
  • 13. Koeller KK, Rushing EJ. From the archives of the AFIP: oligodendroglioma and its variants: radiologic-pathologic correlation. Radiographics. 2005;25:1669–88.
  • 14. Chaichana KL, McGirt MJ, Niranjan A, Olivi A, Burger PC, Quinones-Hinojosa A. Prognostic significance of contrastenhancing low-grade gliomas in adults and a review of the literature. Neurol Res. 2009;31(9):931-9.
  • 15. Scott JN, Brasher PM, Sevick RJ, Rewcastle NB, Forsyth PA. How often are nonenhancing supratentorial gliomas malignant? A population study. Neurology. 2002;59:947–9.
  • 16. White ML, Zhang Y, Kirby P, Ryken TC. Can tumor contrast enhancement be used as a criterion for differentiating tumor grades of oligodendrogliomas? AJNR Am J Neuroradiol. 2005;26:784–90.
  • 17. Hlaihel C, Guilloton L, Guyotat J, Streichenberger N, Honnorat J, Cotton F. Predictive value of multimodality MRI using conventional, perfusion, and spectroscopy MR in anaplastic transformation of low-grade oligodendrogliomas. J Neurooncol. 2010;97(1):73-80.
  • 18. Lebrun C, Fontaine D, Ramaioli A et al. Nice Brain Tumor Study Group. Long-term outcome of oligodendrogliomas. Neurology. 2004; 62(10):1783-7.
  • 19. Park CK, Kim JH, Moon MJ et al. Investigation of molecular factors associated with malignant transformation of oligodendroglioma by proteomic study of a single case of rapid tumor progression. J Cancer Res Clin Oncol. 2008;134(2):255-6.
  • 20. Fellah S, Caudal D, De Paula AM et al. Multimodal MR imaging (diffusion, perfusion, and spectroscopy): is it possible to distinguish oligodendroglial tumor grade and 1p/19q codeletion in the pretherapeutic diagnosis? AJNR Am J Neuroradiol. 2013; 34: 1326–33.

Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik ve Radyolojik Sonuçlarının Prognoza Etkisi

Year 2017, Volume: 4 Issue: 2, 1 - 5, 01.08.2017

Abstract

Oligodendroglial tümörler en sık görülen üçüncü
intrakranyal glial hücre kökenli  primer
beyin tümörleridir. Oligodendrogliomlar Dünya Sağlık Örgütü (DSÖ) santral sinir
sistemi tümörlerinin histolojik sınıflandırmasına göre Derece 2 (klasik) veya
Derece 3 (anaplastik) olarak sınıflandırılmaktadır. Bu çalışmanın amacı
kliniğimizde oligodendrogliom tanısı alan hastaların takiplerinde rekürrense sebep
olan risk faktörlerinin retrospektif analizini yapmaktır. Bu çalışma 2008-2013
yılları arasında Dokuz Eylül Üniversitesi Tıp Fakültesi Beyin ve Sinir
Cerrahisi Kliniğinde ameliyat edilen ve patoloji sonucu Derece 2 ve 3
oligodendrogliom ile uyumlu olan 18 hastayı kapsamaktadır. Çalışmamızdaki
hastaların 12’si (% 66.7) erkek ve 6’sı (% 33.3) kadın idi. Hastaların başvuru
yaş ortalaması 45.22±11.41 (aralık 26-65) idi. Hastaların 6’sı  (% 33.3) oligodendrogliom (DSÖ derece
II),  12’si (%66.7) anaplastik oligodendrogliom
(DSÖ derece III) olarak değerlendirildi. Patoloji sonuçlarına göre DSÖ derece 2
ve derece 3 olarak ikiye ayrılan gruplar radyolojik görüntüler eşliğinde
karşılaştırıldığında; kalsifikasyon (p=0.600), orta hat şifti (p= 0.316), tümör
lokasyonu (p= 0.114) ve ölüm oranı (p= 0.114) arasında istatistiksel olarak
fark saptanmadı. Gelecekte biyobelirteçler ve moleküler çalışmalar tümör tanı
ve takibinde kullanılacak, rekürrense sebep olan risk faktörleri daha ayrıntılı
tanımlanacaktır.

References

  • 1. Ostrom QT, Gittleman H, Liao P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007-2011. Neuro Oncol. 2014;16(Suppl 4):1–63.
  • 2. Aldape K, Nejad R, Louis DN, Zadeh G.Integrating molecular markers into the World Health Organization classification of CNS tumors: a survey of the neuro-oncology community. Neuro Oncol. 2017;19(3):336-344.
  • 3. Louis DN, Perry A, Reifenberger G et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016;131(6):803-20.
  • 4. Wesseling P, van den Bent M, Perry A. Oligodendroglioma: pathology, molecular mechanisms and markers.. Acta Neuropathol. 2015;129(6):809-27.
  • 5. Ino Y, Betensky RA, Zlatescu MC, et al. Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. Clin Cancer Res 2001;7: 839–45.
  • 6. Olson JD, Riedel E, DeAngelis LM. Long-term outcome of low-grade oligodendroglioma and mixed glioma. Neurology. 2000;54(7):1442–8.
  • 7. Lebrun C, Fontaine D, Ramaioli A et al. Long-term outcome of oligodendrogliomas. Neurology. 2004;62(10), 1783–7.
  • 8. Smits M. Imaging of oligodendroglioma. Br J Radiol. 2016;89(1060):20150857.
  • 9. Wessels PH, Weber WE, Raven G, et al. Supratentorial grade II astrocytoma: biological features and clinical course. Lancet Neurol 2003;2(7):395–403.
  • 10. Van Den Bent MJ, Bromberg JE, Buckner J. Low-grade and anaplastic oligodendroglioma.. Handb Clin Neurol. 2016;134:361-80.
  • 11. Oktar N, Biray C. Moleküler Tedavide Hedefteki İlk Tümör: Oligodendrogliomlar Türk Nöroşirürji Dergisi. 2005;15(2):130-5. 12. Olson JD, Riedel E, DeAngelis LM. Long-term outcome of low-grade oligodendroglioma and mixed glioma. Neurology. 2000;54(7):1442–8.
  • 13. Koeller KK, Rushing EJ. From the archives of the AFIP: oligodendroglioma and its variants: radiologic-pathologic correlation. Radiographics. 2005;25:1669–88.
  • 14. Chaichana KL, McGirt MJ, Niranjan A, Olivi A, Burger PC, Quinones-Hinojosa A. Prognostic significance of contrastenhancing low-grade gliomas in adults and a review of the literature. Neurol Res. 2009;31(9):931-9.
  • 15. Scott JN, Brasher PM, Sevick RJ, Rewcastle NB, Forsyth PA. How often are nonenhancing supratentorial gliomas malignant? A population study. Neurology. 2002;59:947–9.
  • 16. White ML, Zhang Y, Kirby P, Ryken TC. Can tumor contrast enhancement be used as a criterion for differentiating tumor grades of oligodendrogliomas? AJNR Am J Neuroradiol. 2005;26:784–90.
  • 17. Hlaihel C, Guilloton L, Guyotat J, Streichenberger N, Honnorat J, Cotton F. Predictive value of multimodality MRI using conventional, perfusion, and spectroscopy MR in anaplastic transformation of low-grade oligodendrogliomas. J Neurooncol. 2010;97(1):73-80.
  • 18. Lebrun C, Fontaine D, Ramaioli A et al. Nice Brain Tumor Study Group. Long-term outcome of oligodendrogliomas. Neurology. 2004; 62(10):1783-7.
  • 19. Park CK, Kim JH, Moon MJ et al. Investigation of molecular factors associated with malignant transformation of oligodendroglioma by proteomic study of a single case of rapid tumor progression. J Cancer Res Clin Oncol. 2008;134(2):255-6.
  • 20. Fellah S, Caudal D, De Paula AM et al. Multimodal MR imaging (diffusion, perfusion, and spectroscopy): is it possible to distinguish oligodendroglial tumor grade and 1p/19q codeletion in the pretherapeutic diagnosis? AJNR Am J Neuroradiol. 2013; 34: 1326–33.
There are 19 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section Original Article
Authors

Levent Fırat

Derya Burcu Hazer Rosberg This is me

Ayça Erşen Danyeli

Fadime Akman This is me

Gökmen Reyhanlı This is me

Mehmet Nuri Arda This is me

Publication Date August 1, 2017
Submission Date July 13, 2017
Published in Issue Year 2017 Volume: 4 Issue: 2

Cite

APA Fırat, L., Hazer Rosberg, D. B., Erşen Danyeli, A., Akman, F., et al. (2017). Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik ve Radyolojik Sonuçlarının Prognoza Etkisi. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, 4(2), 1-5.
AMA Fırat L, Hazer Rosberg DB, Erşen Danyeli A, Akman F, Reyhanlı G, Arda MN. Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik ve Radyolojik Sonuçlarının Prognoza Etkisi. MMJ. August 2017;4(2):1-5.
Chicago Fırat, Levent, Derya Burcu Hazer Rosberg, Ayça Erşen Danyeli, Fadime Akman, Gökmen Reyhanlı, and Mehmet Nuri Arda. “Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik Ve Radyolojik Sonuçlarının Prognoza Etkisi”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 4, no. 2 (August 2017): 1-5.
EndNote Fırat L, Hazer Rosberg DB, Erşen Danyeli A, Akman F, Reyhanlı G, Arda MN (August 1, 2017) Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik ve Radyolojik Sonuçlarının Prognoza Etkisi. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 4 2 1–5.
IEEE L. Fırat, D. B. Hazer Rosberg, A. Erşen Danyeli, F. Akman, G. Reyhanlı, and M. N. Arda, “Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik ve Radyolojik Sonuçlarının Prognoza Etkisi”, MMJ, vol. 4, no. 2, pp. 1–5, 2017.
ISNAD Fırat, Levent et al. “Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik Ve Radyolojik Sonuçlarının Prognoza Etkisi”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi 4/2 (August 2017), 1-5.
JAMA Fırat L, Hazer Rosberg DB, Erşen Danyeli A, Akman F, Reyhanlı G, Arda MN. Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik ve Radyolojik Sonuçlarının Prognoza Etkisi. MMJ. 2017;4:1–5.
MLA Fırat, Levent et al. “Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik Ve Radyolojik Sonuçlarının Prognoza Etkisi”. Muğla Sıtkı Koçman Üniversitesi Tıp Dergisi, vol. 4, no. 2, 2017, pp. 1-5.
Vancouver Fırat L, Hazer Rosberg DB, Erşen Danyeli A, Akman F, Reyhanlı G, Arda MN. Oligodendrogliom Tanısı Alan Hastaların Preoperatif Klinik ve Radyolojik Sonuçlarının Prognoza Etkisi. MMJ. 2017;4(2):1-5.