Point Prevalence, Risk Factors and Useful Parameters for Food Allergy in Children with Atopic Dermatitis

Year 2021, Volume: 8 Issue: 2, 84 - 90, 31.08.2021

Nazlı Ercan

Abstract

No consensus has yet been reached on the presence and prevalence of food allergy (FA) in children with atopic dermatitis (AD). To investigate the incidence of FA accompanying AD in preschool children and to determine the parameters that can be used to predict this association. This case-control study is a retrospective analysis of 401 children aged 0-6 years with AD who had a SCORAD index of >15 between 2017-2020 at our university hospital. Children were subgrouped regarding the age of onset of AD (subgroup I: <24 months, subgroup II: ≥ 24 months). The sociodemographic characteristics and allergological test results were studied. Food allergy prevalence of patients with AD to at least one food was 23.6% (n=95). Gender, age of the child, and age of onset of AD increase in BEC were the independent risk factors (p=0.047; 0.004; 0.014 and p=0.012, respectively). Time to start complementary feeding, degree of kinship, and serum specific IgE milk positivity were independent risk factors for study subgroup I (p=0.045, 0.187, 0.019, respectively). In predicting FA in subgroup I, the cut-off point for BEC was 525 K/mm3, and the BEC/WBCs ratio was 0.0522 (73.91% sensitivity, 63.64% specificity). The risk factors and in-vitro parameters determined can guide physicians in predicting the concomitant FA in children with AD.

Keywords

Atopic Dermatitis, Blood Eosinophil Count, Food Allergy, Preschool Children

Supporting Institution

I have no funding source

Project Number

Project/Decision no: 19/412; Meeting no: 2019/18

Thanks

My special thanks to [Naci Murat, Assoc. Prof.] for assistance in performing the statistical analysis of the research data. I am also grateful to [Ozlem Ezgingil, Nurse], who served with love for our patients.

Atopik Dermatitli Çocuklardaki Besin Alerjisini Tahminde Kullanılabilecek Parametreler ve Risk Faktörleri, Nokta Prevalans

Abstract

Atopik dermatit’li çocuklarda besin alerjisi varlığı ve yaygınlığı konusunda fikir birliğine varılamamıştır. Çalışmamızda, okul öncesi çocuklarda atopik dermatit’e eşlik eden besin alerjisi insidansını araştırmak ve bu ilişkiyi tahmin etmede kullanılabilecek parametreleri belirlemeyi amaçladık. Bu vaka-kontrol çalışması, üniversite hastanemizde 2017-2020 yılları arasında SCORAD indeksi >15 olan, 0-6 yaş arası AD'li toplam 401 çocuğun retrospektif bir incelemesidir. Araştırmaya dahil edilen çocukların sosyodemografik özellikleri ve alerji testleri incelenmiştir. Atopik dermatit’in başlangıç yaşına göre çocuklar iki alt gruba ayrılmıştır. (Alt grup I: <24 ay, Alt grup II: ≥24 ay).
Atopik dermatit’li hastaların en az bir yiyeceğe karşı besin alerjisi prevalansı %23.6 (n=95) idi. Cinsiyet, çocuğun yaşı, atopik dermatit başlangıç yaşı ve kan eozinofil sayısındaki (KES) artış bağımsız risk faktörleri olarak saptandı. (p-değerleri sırasıyla; 0.047, 0.004, 0.014 ve 0.012). Tamamlayıcı beslenmeye başlama zamanı, akrabalık derecesi ve serum süt spesifik IgE pozitifliği alt grup I için bağımsız risk faktörleriydi (p-değerleri sırasıyla; 0.045, 0.187, 0.019). Alt grup I'deki besin alerjisini tahmin etmede KES için kesme noktası 525 K/mm3 ve KES/WBC oranı 0.0522 idi (duyarlılık %73.91; özgüllük %63.64). Araştırmamızda belirlenen risk faktörleri ve in-vitro parametreler klinisyenlere AD'li çocuklarda eşlik eden besin alerjisini tahmin etmede yol gösterici olabilir.

Keywords

Atopik Dermatit, Besin Alerjisi, Kan Eozinofil Sayısı, Okul Öncesi Çocuklar

Project Number

Project/Decision no: 19/412; Meeting no: 2019/18

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