5,5'-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1YL)METHYL]-4-ETHYL2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} MANNICH BAZININ FARELERİN BÖBREK, KARACİĞER VE SERUMLARINDAKİ MDA VE VİTAMİN DÜZEYLERİNE ETKİSİ

Year 2015, , 29 - 36, 07.04.2015

Akif Parlak Sait Çelik , Mustafa Karatepe , Metin Koparır

https://doi.org/10.12739/NWSA.2015.10.2.3A0070

Abstract

1,2,4-triazol ve türevlerinin çeşitli farmakolojik aktivite gösterdiği bildirilmiştir. Mannich bazlar antibakteriyel, antienflamatuar, antifungal, sıtma ve pestisit özellikleri gibi güçlü biyolojik aktivitelere sahiptir. Mannich bazları türevleri daha önce bildirildiği gibi yeniden sentezlendi[1]. Bu çalışmada, bis-1,2,4 – triazol içeren bir Mannich bazı bileşiğinin farelerin serum, karaciğer ve böbreklerindeki malondialdehit (MDA) ve antioksidan vitaminler (A,E,C) seviyelerine olan etkileri incelendi. Malondialdehit düzeyi ve vitaminler HPLC tarafından belirlendi. Bileşik kontrol ile karşılaştırıldığında iyi aktivite gösterdi.

Keywords

1,2,4-, Triazol, Mannich Baz, Vitamin, Serum, Karaciğer, Böbrek, Fare

THE EFFECTS OF 5,5'-BUTANE-1,4-DIYLBIS{2-[(4-BENZYLPIPERAZIN-1 YL)METHYL]-4-ETHYL-2,4-DIHYDRO-3H- 1,2,4-TRIAZOLE-3-THIONE} ON MDA LEVEL AND VITAMINS IN SERUM, LIVER AND KIDNEY OF RATS

Abstract

The 1,2,4-triazole and its derivatives were reported to exhibit various pharmacological activities. Mannich bases possess potent biological advantages due to being antibacterial, antifungal, antiinflammatory, antimalarial and. They also have pesticide properties. As previously reported, Mannich bases derivatives were synthesized [1]. In this study, the effects of newly synthesized a Mannich base compound which contain bis-1,2,4– triazole on the level of malondialdehyde (MDA) and antioxidant vitamins (A,E,C) of the serum, liver and kidney of rats have been investigated. Besides, the level of malondialdehyde and vitamins has been determined by HPLC. Compared to the control group, the compound showed satisfactory performance

Keywords

1, 2, 4- Triazole, Mannich Bases, Vitamin, Serum, Kidney, Liver, Rat

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