Lamotrigine induced seizures in juvenile myoclonic epilepsy

Year 2013, Volume: 30 Issue: 2, 207 - 208, 31.07.2013

Betül Acar Ersel Dağ Yakup Türkel

https://doi.org/10.5835/jecm.omu.30.02.027

Abstract

Juvenile myoclonic epilepsy (JME) is a common epileptic syndrome. Before the development of the new antiepileptic drugs (AEDs) after the 1990s, Valproate (VPA) was the first-line treatment in juvenile myoclonic epilepsy. However, the frequent adverse effects and the risk for teratogenicity have resulted in a search for alternative therapies especially in women. Lamotrigine (LTG), topiramate, and levetiracetam, have been used as monotherapy or adjunctive therapy for juvenile myoclonic epilepsy in small patient series. We report a case of a thirty one-years-old female suffered from severe aggravation in myoclonic and generalized tonic-clonic (GTC) seizures after decreasing the lose of VPA and initiating LTG.

Keywords

Antiepileptic drug, Seizure, Juvenile myoclonic epilepsy, Lamotrigine

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