Research Article
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Year 2022, Volume: 39 Issue: 1, 91 - 96, 01.01.2022

Abstract

References

  • 1. Jacob B, Parsa R, Frizzell R, Mearns A, Smith P. Mediastinal tuberculosis in Bradford, United Kingdom: the role of mediastinoscopy. Int J Tuberc Lung Dis. 2011;15(2):240-5, i. PMID: 21219688.
  • 2. Kang W, Yu J, Du J, Yang S, Chen H, Liu J, et al. The epidemiology of extrapulmonary tuberculosis in China: A large-scale multi-center observational study. PLoS One. 2020;15(8): e0237753. doi: 10.1371/journal.pone.0237753. PMID: 32822367; PMCID: PMC7446809.
  • 3. Issoufou I, Harmouchi H, Efared B, Belliraj L, Ammor FZ, Lakranbi M, et al. Quelle contribution pour la médiastinoscopie dans les lésions médiastinales spécifiques non tumorales? [What contribution for mediastinoscopy in non-tumor specific mediastinal lesions?]. Rev Pneumol Clin. 2018;74(4):242-247. French. doi: 10.1016/j.pneumo.2018.05.003. Epub 2018 Jul 17. PMID: 30017753.
  • 4. Ayed AK, Behbehani NA. Diagnosis and treatment of isolated tuberculous mediastinal lymphadenopathy in adults. Eur J Surg. 2001; 167:334-338.
  • 5. Sayar A, Ölçmen A, Metin M, Güleç H, Demir A, Ölçmen M. Role of Mediastinoscopy in Intrathoracic Tuberculous Lymphadenitis. Asian Cardiovasc Thorac Ann. 2000;8(3):253-255. doi:10.1177/021849230000800314
  • 6. Bilgin Büyükkarabacak Y, Taslak Şengül A, Meydan BC, Çelik B, Pirzirenli MG, Gürz S, Sürücü ZP, Başoğlu A. The risk of tumor cell dissemination in mediastinoscopy: a cytological study. Turk J Med Sci. 2015;45(4):872-6. doi: 10.3906/sag-1406-11. PMID: 26422860.
  • 7. Chunawala Z, Shah I. Clinical Profile of Children with Mediastinal Tuberculosis. J Trop Pediatr. 2021; 67(3): fmaa056. doi: 10.1093/tropej/fmaa056. PMID: 32814966.
  • 8. Iyengar KB, Kudru CU, Nagiri SK, Rao AC. Tuberculous mediastinal lymphadenopathy in an adult. BMJ Case Rep. 2014; 2014: bcr2013200718. doi: 10.1136/bcr-2013-200718. PMID: 24419636; PMCID: PMC3902323.
  • 9. Singh S, Pandey D, Ahmad Z, Bhargava R, Hameed I, Mehfooz N. Unusual presentation of tuberculosis. Trop Doct. 2009; 39(3):183-4. doi: 10.1258/td.2008.080311. PMID: 19535763.
  • 10. Webb WR. Themediastinum: mediastinalmasses. In: Webb WR, Higgins CB, eds. Thoracicimaging: pulmonaryandcardiothoracicradiology. 2nd edn. Philadelphia, PA: Lippincott Williams &Wilkins, 2011;219–85.
  • 11. İntepe Y, Kıyık M, Tigin H, Durmaz A, Epöztürk K., Çıkrıkçıoğlu S. Diagnostic value of Acid Fast Bascilli at BAL in Patients who are accepted as clinically and radiologically active tuberculosis with negative sputum smear. Bozok Med J. 2014; 4(2), 31 – 36.
  • 12. Gümüş S, Deniz Ö, Tozkoparan E. Diagnostic Value of Bronchial Lavage and Trans bronchial Parenchymal Biopsy in the Diagnosis of Smear Negative Patients Suspected of Having Tuberculosis According to Chest X-rays. Torax Journal 2007; 8(2): 101-109.
  • 13. Eroğlu C. PCR in the diagnosis of tuberculosis. Tuberculosis Symposium in the 21st Century and II. Tuberculosis Laboratory Diagnostic Methods Course, Samsun 2003.
  • 14. Fujiwara T, Yoshida Y, Yamada S, Kawamata H, Fujimori T, Imawari M. A case of primary esophageal tuberculosis diagnosed by identification of Mycobacteria in paraffin-embedded esophageal biopsy specimens by polymerase chain reaction. J Gastroenterol. 2003;38(1):74-8. doi: 10.1007/s005350300009. PMID: 12560925.
  • 15. Senturk A, Arguder E, Hezer H, Babaoglu E, Kilic H, Karalezli A, Hasanoglu HC. Rapid diagnosis of mediastinal tuberculosis with polymerase chain reaction evaluation of aspirated material taken by endobronchial ultrasound-guided transbronchial needle aspiration. J Investig Med. 2014; 62(6):885-9. doi: 10.1097/01.JIM.0000446837.75352.3b. PMID: 24866460.
  • 16. Ponn BR. Invasive diagnostic procedures. In: Shields TW,Lo Cicero J, Ponn RB, Rusch VW, editors. General Thoracic Surgery. 6th ed. Philadelphia, PA, USA: Lippincott Williams &Wilkins; 2005; 299‒313.
  • 17. Al-Sofyani M, Maziak DE, Shamji FM. Cervical mediastinoscopy incisional metastasis. Ann Thorac Surg. 2000; 69(4):1255-7. doi: 10.1016/s0003-4975(99)01461-7. PMID: 10800833.
  • 18. Eickhoff L, Golpon H, Zardo P, Suhling H, Welte T, Jonigk D, Gottlieb J, Fuehner T. Endobronchial Ultrasound in Suspected Non-Malignant Mediastinal Lymphadenopathy. Pneumologie. 2018;72(8):559-567. English. doi: 10.1055/a-0583-0265. Epub 2018 May 22. PMID: 29788514.

The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?

Year 2022, Volume: 39 Issue: 1, 91 - 96, 01.01.2022

Abstract

Mediastinoscopy is the gold standard for diagnosis in the absence of parenchymal lesions in mediastinal tuberculosis lymphadenitis. During mediastinoscopy biopsy, tuberculous bacillus seeding into the mediastinum is a rare complication. This study aimed to test the safety of mediastinoscopy in terms of Mycobacterium tuberculosis seeding in the mediastinum by microbiologically evaluating mediastinal lavage samples taken before and after biopsy. Classical cervical mediastinoscopy was performed all of patients and who were reported as granulomatous inflammatory events results of histopathological examinations and who underwent mediastinal lavage before and after biopsy, were included in the study. All the lavage fluids were tested for AFB and subjected to Mycobacterium tuberculosis PCR DNA testing and standard tuberculosis culture. The patients were divided into two groups, Group 1: Necrotizing granulomatous inflammation, Group 2: non-necrotizing granulomatous inflammation. The microbiological tests of the patients in Group 1 were negative before biopsy. However, in two patients of Group 1, the results of cultures of lavage fluids that taken from after biopsy were positive for tuberculosis. In all patients in Group 2, all microbiological tests of the lavage fluids were negative (Power of the decision: 99.8%, with 5% error). All of patients in group 1, Antituberculosis treatment was initiated and continued for 6 months. There weren’t seen any serius complications due to treatment and recurrence during the follow-up period. Mediastinoscopy can be used safely, with low morbidity and mortality rates and a high success rate for the diagnosis of mediastinal tuberculosis.

References

  • 1. Jacob B, Parsa R, Frizzell R, Mearns A, Smith P. Mediastinal tuberculosis in Bradford, United Kingdom: the role of mediastinoscopy. Int J Tuberc Lung Dis. 2011;15(2):240-5, i. PMID: 21219688.
  • 2. Kang W, Yu J, Du J, Yang S, Chen H, Liu J, et al. The epidemiology of extrapulmonary tuberculosis in China: A large-scale multi-center observational study. PLoS One. 2020;15(8): e0237753. doi: 10.1371/journal.pone.0237753. PMID: 32822367; PMCID: PMC7446809.
  • 3. Issoufou I, Harmouchi H, Efared B, Belliraj L, Ammor FZ, Lakranbi M, et al. Quelle contribution pour la médiastinoscopie dans les lésions médiastinales spécifiques non tumorales? [What contribution for mediastinoscopy in non-tumor specific mediastinal lesions?]. Rev Pneumol Clin. 2018;74(4):242-247. French. doi: 10.1016/j.pneumo.2018.05.003. Epub 2018 Jul 17. PMID: 30017753.
  • 4. Ayed AK, Behbehani NA. Diagnosis and treatment of isolated tuberculous mediastinal lymphadenopathy in adults. Eur J Surg. 2001; 167:334-338.
  • 5. Sayar A, Ölçmen A, Metin M, Güleç H, Demir A, Ölçmen M. Role of Mediastinoscopy in Intrathoracic Tuberculous Lymphadenitis. Asian Cardiovasc Thorac Ann. 2000;8(3):253-255. doi:10.1177/021849230000800314
  • 6. Bilgin Büyükkarabacak Y, Taslak Şengül A, Meydan BC, Çelik B, Pirzirenli MG, Gürz S, Sürücü ZP, Başoğlu A. The risk of tumor cell dissemination in mediastinoscopy: a cytological study. Turk J Med Sci. 2015;45(4):872-6. doi: 10.3906/sag-1406-11. PMID: 26422860.
  • 7. Chunawala Z, Shah I. Clinical Profile of Children with Mediastinal Tuberculosis. J Trop Pediatr. 2021; 67(3): fmaa056. doi: 10.1093/tropej/fmaa056. PMID: 32814966.
  • 8. Iyengar KB, Kudru CU, Nagiri SK, Rao AC. Tuberculous mediastinal lymphadenopathy in an adult. BMJ Case Rep. 2014; 2014: bcr2013200718. doi: 10.1136/bcr-2013-200718. PMID: 24419636; PMCID: PMC3902323.
  • 9. Singh S, Pandey D, Ahmad Z, Bhargava R, Hameed I, Mehfooz N. Unusual presentation of tuberculosis. Trop Doct. 2009; 39(3):183-4. doi: 10.1258/td.2008.080311. PMID: 19535763.
  • 10. Webb WR. Themediastinum: mediastinalmasses. In: Webb WR, Higgins CB, eds. Thoracicimaging: pulmonaryandcardiothoracicradiology. 2nd edn. Philadelphia, PA: Lippincott Williams &Wilkins, 2011;219–85.
  • 11. İntepe Y, Kıyık M, Tigin H, Durmaz A, Epöztürk K., Çıkrıkçıoğlu S. Diagnostic value of Acid Fast Bascilli at BAL in Patients who are accepted as clinically and radiologically active tuberculosis with negative sputum smear. Bozok Med J. 2014; 4(2), 31 – 36.
  • 12. Gümüş S, Deniz Ö, Tozkoparan E. Diagnostic Value of Bronchial Lavage and Trans bronchial Parenchymal Biopsy in the Diagnosis of Smear Negative Patients Suspected of Having Tuberculosis According to Chest X-rays. Torax Journal 2007; 8(2): 101-109.
  • 13. Eroğlu C. PCR in the diagnosis of tuberculosis. Tuberculosis Symposium in the 21st Century and II. Tuberculosis Laboratory Diagnostic Methods Course, Samsun 2003.
  • 14. Fujiwara T, Yoshida Y, Yamada S, Kawamata H, Fujimori T, Imawari M. A case of primary esophageal tuberculosis diagnosed by identification of Mycobacteria in paraffin-embedded esophageal biopsy specimens by polymerase chain reaction. J Gastroenterol. 2003;38(1):74-8. doi: 10.1007/s005350300009. PMID: 12560925.
  • 15. Senturk A, Arguder E, Hezer H, Babaoglu E, Kilic H, Karalezli A, Hasanoglu HC. Rapid diagnosis of mediastinal tuberculosis with polymerase chain reaction evaluation of aspirated material taken by endobronchial ultrasound-guided transbronchial needle aspiration. J Investig Med. 2014; 62(6):885-9. doi: 10.1097/01.JIM.0000446837.75352.3b. PMID: 24866460.
  • 16. Ponn BR. Invasive diagnostic procedures. In: Shields TW,Lo Cicero J, Ponn RB, Rusch VW, editors. General Thoracic Surgery. 6th ed. Philadelphia, PA, USA: Lippincott Williams &Wilkins; 2005; 299‒313.
  • 17. Al-Sofyani M, Maziak DE, Shamji FM. Cervical mediastinoscopy incisional metastasis. Ann Thorac Surg. 2000; 69(4):1255-7. doi: 10.1016/s0003-4975(99)01461-7. PMID: 10800833.
  • 18. Eickhoff L, Golpon H, Zardo P, Suhling H, Welte T, Jonigk D, Gottlieb J, Fuehner T. Endobronchial Ultrasound in Suspected Non-Malignant Mediastinal Lymphadenopathy. Pneumologie. 2018;72(8):559-567. English. doi: 10.1055/a-0583-0265. Epub 2018 May 22. PMID: 29788514.
There are 18 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Yasemin Büyükkarabacak 0000-0001-9676-9313

Mehmet Pirzirenli 0000-0002-1831-2710

Selçuk Gürz 0000-0003-4584-4840

Ayşen Taslak Şengül 0000-0002-1558-8228

Yeliz Tanrıverdi Çaycı 0000-0002-9251-1953

Ahmet Başoğlu 0000-0002-6312-5658

Early Pub Date January 3, 2022
Publication Date January 1, 2022
Submission Date June 8, 2021
Acceptance Date June 12, 2021
Published in Issue Year 2022 Volume: 39 Issue: 1

Cite

APA Büyükkarabacak, Y., Pirzirenli, M., Gürz, S., Taslak Şengül, A., et al. (2022). The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?. Journal of Experimental and Clinical Medicine, 39(1), 91-96.
AMA Büyükkarabacak Y, Pirzirenli M, Gürz S, Taslak Şengül A, Tanrıverdi Çaycı Y, Başoğlu A. The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?. J. Exp. Clin. Med. January 2022;39(1):91-96.
Chicago Büyükkarabacak, Yasemin, Mehmet Pirzirenli, Selçuk Gürz, Ayşen Taslak Şengül, Yeliz Tanrıverdi Çaycı, and Ahmet Başoğlu. “The Risk of Tuberculosis Bacilli Seeding During Mediastinoscopy in Mediastinal Tuberculosis: Is It Clinically Important?”. Journal of Experimental and Clinical Medicine 39, no. 1 (January 2022): 91-96.
EndNote Büyükkarabacak Y, Pirzirenli M, Gürz S, Taslak Şengül A, Tanrıverdi Çaycı Y, Başoğlu A (January 1, 2022) The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?. Journal of Experimental and Clinical Medicine 39 1 91–96.
IEEE Y. Büyükkarabacak, M. Pirzirenli, S. Gürz, A. Taslak Şengül, Y. Tanrıverdi Çaycı, and A. Başoğlu, “The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?”, J. Exp. Clin. Med., vol. 39, no. 1, pp. 91–96, 2022.
ISNAD Büyükkarabacak, Yasemin et al. “The Risk of Tuberculosis Bacilli Seeding During Mediastinoscopy in Mediastinal Tuberculosis: Is It Clinically Important?”. Journal of Experimental and Clinical Medicine 39/1 (January 2022), 91-96.
JAMA Büyükkarabacak Y, Pirzirenli M, Gürz S, Taslak Şengül A, Tanrıverdi Çaycı Y, Başoğlu A. The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?. J. Exp. Clin. Med. 2022;39:91–96.
MLA Büyükkarabacak, Yasemin et al. “The Risk of Tuberculosis Bacilli Seeding During Mediastinoscopy in Mediastinal Tuberculosis: Is It Clinically Important?”. Journal of Experimental and Clinical Medicine, vol. 39, no. 1, 2022, pp. 91-96.
Vancouver Büyükkarabacak Y, Pirzirenli M, Gürz S, Taslak Şengül A, Tanrıverdi Çaycı Y, Başoğlu A. The risk of tuberculosis bacilli seeding during mediastinoscopy in mediastinal tuberculosis: Is it clinically important?. J. Exp. Clin. Med. 2022;39(1):91-6.