Research Article
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Year 2022, Volume: 39 Issue: 3, 848 - 856, 30.08.2022

Abstract

Supporting Institution

TÜBİTAK

Project Number

220S126

References

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  • Hasler WL. Small Intestinal Motility. In: Johnson LR, editor. Physiology of the Gastrointestinal Tract. New York, Elsevier; 2006. 935-964.
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  • Aizawa I, Itoh Z, Harris V, Unger RH. Plasma somatostatin-like immunoreactivity during the interdigestive period in the dog. J Clin Invest. 1981 Jul;68(1):206-13. doi: 10.1172/jci110236. PMID: 6114112; PMCID: PMC370788.
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  • Bozkurt A, Näslund E, Holst JJ, Hellström PM. GLP-1 and GLP-2 act in concert to inhibit fasted, but not fed, small bowel motility in the rat. Regul Pept. 2002 Jul 15;107(1-3):129-35. doi: 10.1016/s0167-0115(02)00095-2. PMID: 12137975.
  • Edholm T, Levin F, Hellström PM, Schmidt PT. Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept. 2004 Sep 15;121(1-3):25-30. doi: 10.1016/j.regpep.2004.04.001. PMID: 15256270.
  • Schmidt PT, Bozkurt A, Hellström PM. Tachykinin-stimulated small bowel myoelectric pattern: sensitization by NO inhibition, reversal by neurokinin receptor blockade. Regul Pept. 2002 Apr 15;105(1):15-21. doi: 10.1016/s0167-0115(01)00369-x. PMID: 11853867.
  • Galligan JJ, Furness JB, Costa M. Migration of the myoelectric complex after interruption of the myenteric plexus: intestinal transection and regeneration of enteric nerves in the guinea pig. Gastroenterology. 1989 Nov;97(5):1135-46. doi: 10.1016/0016-5085(89)91683-1. PMID: 2571545.
  • Romanski KW. Mechanisms controlling the gastrointestinal migrating motor complex. JPCCR. 2009. 3, 11–19.
  • Pertwee RG, Ross RA. Cannabinoid receptors and their ligands. Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):101-21. doi: 10.1054/plef.2001.0341. PMID: 12052030.
  • Camilleri M. Cannabinoids and gastrointestinal motility: Pharmacology, clinical effects, and potential therapeutics in humans. Neurogastroenterol Motil. 2018 Sep;30(9):e13370. doi: 10.1111/nmo.13370. Epub 2018 May 10. PMID: 29745439; PMCID: PMC6150799.
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  • Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev. 2002 Jun;54(2):161-202. doi: 10.1124/pr.54.2.161. PMID: 12037135.
  • Vera G, Fichna, J, Abalo, R. Cannabinoids and Effects on the Gastrointestinal Tract. A Focus on Motility. Handbook of Cannabis and Related Pathologies Biology, Pharmacology. Diagnosis, and Treatment. 2017. 947-957.
  • Urangaa JA, Vera G, Abalo R. Cannabinoid pharmacology and therapy in gut disorders. Biochem Pharmacol. 2018. 157:134-147.
  • Hinds NM, Ullrich K, Smid SD. Cannabinoid 1 (CB1) receptors coupled to cholinergic motorneurones inhibit neurogenic circular muscle contractility in the human colon. Br J Pharmacol. 2006 May;148(2):191-9. doi: 10.1038/sj.bjp.0706710. PMID: 16520743; PMCID: PMC1617060.
  • Abalo R, Chen C, Vera G, Fichna J, Thakur GA, López-Pérez AE, Makriyannis A, Martín-Fontelles MI, Storr M. In vitro and non-invasive in vivo effects of the cannabinoid-1 receptor agonist AM841 on gastrointestinal motor function in the rat. Neurogastroenterol Motil. 2015 Dec;27(12):1721-35. doi: 10.1111/nmo.12668. Epub 2015 Sep 20. PMID: 26387676; PMCID: PMC4918633.
  • Izzo, A. A., Mascolo, N., Tonini, M., and Capasso, F. (2000). Modulation of peristalsis by cannabinoid CB (1) ligands in the isolated guinea-pig ileum. British journal of pharmacology, 129 (5), 984–990.
  • Szymaszkiewicz A, Zielinska M, Li K, Ramanathan M, Alam S, Hou DR, Fichna J, Storr M. Novel derivatives of 1,2,3-triazole, cannabinoid-1 receptor ligands modulate gastrointestinal motility in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Apr;391(4):435-444. doi: 10.1007/s00210-018-1465-9. Epub 2018 Feb 5. PMID: 29404698.
  • Coutts, A. A., Brewster, N., Ingram, T., Razdan, R. K., and Pertwee, R. G. (2000). Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine. British journal of pharmacology, 129 (4), 645–652.
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  • Izzo, A. A., Mascolo, N., Capasso, R., Germanò, M. P., De Pasquale, R., and Capasso, F. (1999c). Inhibitory effect of cannabinoid agonists on gastric emptying in the rat. Naunyn-Schmiedeberg's archives of pharmacology, 360 (2), 221–223.
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  • Pinto L, Izzo AA, Cascio MG, Bisogno T, Hospodar-Scott K, Brown DR, Mascolo N, Di Marzo V, Capasso F. Endocannabinoids as physiological regulators of colonic propulsion in mice. Gastroenterology. 2002 Jul;123(1):227-34. doi: 10.1053/gast.2002.34242. PMID: 12105851.
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Role of cannabinoid receptor-2 in small intestinal fasted myoelectric activity of rats

Year 2022, Volume: 39 Issue: 3, 848 - 856, 30.08.2022

Abstract

Cannabinoid receptor-1 (CB1R) and cannabinoid receptor-2 (CB2R) have significant roles in the motility of the esophagus, small intestine, and colon in the postprandial period as well as gastric emptying, secretion, and defecation in the gastrointestinal system. Also, our previous study showed that activation of peripheral CB1R inhibited migrating myoelectric complex (MMC), forming the source of fasted small intestinal motility. However, the role of the cannabinoid receptor-2 (CB2R) on the MMC pattern is still unknown. The present study aimed to investigate the roles of peripheral and central CB2Rs in the formation and regulation of small intestine MMC patterns in rats. In this study, 42 adult male Sprague-Dawley rats were used (n:7). Bipolar electrodes were implanted in three different jejunum sites of rats (J1, J2, J3) to record the MMC pattern. A cannula was implanted in the right lateral ventricle to perform drug intracerebroventricular (i.c.v.) while a catheter was placed in the right jugular vein to inject the drug intravenously (i.v). After the amelioration period, experiments were carried out following an 18-hour fasted period and later was taken at least a one-hour baseline recording of the MMC pattern. Then, JWH 133, a CB2R agonist, was injected i.v. (1.25-10 mg/kg) or i.c.v. (2.5-20 µg/rat) and also AM 630, a CB2R antagonist, was administered i.v. (0.25-2 mg/kg) or i.c.v. (2.5-20 µg/rat). The effects of JWH 133 or AM 630 on the MMC pattern were compared to the vehicle group (10% dimethyl sulfoxide). Centrally or peripherally injected JWH 133 and AM 630 did not cause any change in the spike frequency and the number of the MMC cycle. The results of the present study propose that CB2Rs are involved in neither endogenous formation nor exogenous regulation of the fasting myoelectric activity in healthy fasted rats.

Project Number

220S126

References

  • Bozkurt A. Sindirim Sisteminde Motilite. In: Agar E, editor. İnsan Fizyolojisi. İstanbul: İstanbul Tıp Kitabevi; 2020.459-475.
  • Itoh Z, Sekiguchi T. Interdigestive motor activity in health and disease. Scand J Gastroenterol Suppl. 1983;82:121-34. PMID: 6579625.
  • Foulk WT, Code CF, Morlock CG, Bargen JA. A study of the motility patterns and the basic rhythm in the duodenum and upper part of the jejunum of human beings. Gastroenterology. 1954 Apr;26(4):601-11. PMID: 13151368.
  • Hasler WL. Small Intestinal Motility. In: Johnson LR, editor. Physiology of the Gastrointestinal Tract. New York, Elsevier; 2006. 935-964.
  • Szurszewski JH. A migrating electric complex of canine small intestine. Am J Physiol. 1969 Dec;217(6):1757-63. doi: 10.1152/ajplegacy.1969.217.6.1757. PMID: 5353053i
  • Keane FB, DiMagno EP, Dozois RR, Go VL. Relationships among canine interdigestive exocrine pancreatic and biliary flow, duodenal motor activity, plasma pancreatic polypeptide, and motilin. Gastroenterology. 1980 Feb;78(2):310-6. PMID: 7350054.
  • Aizawa I, Itoh Z, Harris V, Unger RH. Plasma somatostatin-like immunoreactivity during the interdigestive period in the dog. J Clin Invest. 1981 Jul;68(1):206-13. doi: 10.1172/jci110236. PMID: 6114112; PMCID: PMC370788.
  • Owyang C, Achem-Karam SR, Vinik AI. Pancreatic polypeptide and intestinal migrating motor complex in humans. Effect of pancreaticobiliary secretion. Gastroenterology. 1983 Jan;84(1):10-7. PMID: 6847838.
  • Lördal M, Wallén H, Hjemdahl P, Beck O, Hellström PM. Concentration-dependent stimulation of intestinal phase III of migrating motor complex by circulating serotonin in humans. Clin Sci (Lond). 1998 Jun;94(6):663-70. doi: 10.1042/cs0940663. PMID: 9854466.
  • Lördal M, Hellström PM. Serotonin stimulates migrating myoelectric complex via 5-HT3-receptors dependent on cholinergic pathways in rat small intestine. Neurogastroenterol Motil. 1999 Feb;11(1):1-10. doi: 10.1046/j.1365-2982.1999.00125.x. PMID: 10087529
  • Feurle GE, Pfeiffer A, Schmidt T, Dominguez-Munoz E, Malfertheiner P, Hamscher G. Phase III of the migrating motor complex: associated with endogenous xenin plasma peaks and induced by exogenous xenin. Neurogastroenterol Motil. 2001 Jun;13(3):237-46. doi: 10.1046/j.1365-2982.2001.00263.x. PMID: 11437986.
  • Bozkurt A, Näslund E, Holst JJ, Hellström PM. GLP-1 and GLP-2 act in concert to inhibit fasted, but not fed, small bowel motility in the rat. Regul Pept. 2002 Jul 15;107(1-3):129-35. doi: 10.1016/s0167-0115(02)00095-2. PMID: 12137975.
  • Edholm T, Levin F, Hellström PM, Schmidt PT. Ghrelin stimulates motility in the small intestine of rats through intrinsic cholinergic neurons. Regul Pept. 2004 Sep 15;121(1-3):25-30. doi: 10.1016/j.regpep.2004.04.001. PMID: 15256270.
  • Schmidt PT, Bozkurt A, Hellström PM. Tachykinin-stimulated small bowel myoelectric pattern: sensitization by NO inhibition, reversal by neurokinin receptor blockade. Regul Pept. 2002 Apr 15;105(1):15-21. doi: 10.1016/s0167-0115(01)00369-x. PMID: 11853867.
  • Galligan JJ, Furness JB, Costa M. Migration of the myoelectric complex after interruption of the myenteric plexus: intestinal transection and regeneration of enteric nerves in the guinea pig. Gastroenterology. 1989 Nov;97(5):1135-46. doi: 10.1016/0016-5085(89)91683-1. PMID: 2571545.
  • Romanski KW. Mechanisms controlling the gastrointestinal migrating motor complex. JPCCR. 2009. 3, 11–19.
  • Pertwee RG, Ross RA. Cannabinoid receptors and their ligands. Prostaglandins Leukot Essent Fatty Acids. 2002 Feb-Mar;66(2-3):101-21. doi: 10.1054/plef.2001.0341. PMID: 12052030.
  • Camilleri M. Cannabinoids and gastrointestinal motility: Pharmacology, clinical effects, and potential therapeutics in humans. Neurogastroenterol Motil. 2018 Sep;30(9):e13370. doi: 10.1111/nmo.13370. Epub 2018 May 10. PMID: 29745439; PMCID: PMC6150799.
  • Johnson MR, Rice KC, Howlett A, Melvin LS, Herkenham M. The cannabinoid receptor-pharmacologic identification, anatomical localization and cloning. NIDA Res Monogr. 1992;119:86-90. PMID: 1435988.
  • Pacher P, Mechoulam R. Is lipid signaling through cannabinoid 2 receptors part of a protective system? Prog Lipid Res. 2011 Apr;50(2):193-211. doi: 10.1016/j.plipres.2011.01.001. Epub 2011 Feb 2. PMID: 21295074; PMCID: PMC3062638.
  • Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev. 2002 Jun;54(2):161-202. doi: 10.1124/pr.54.2.161. PMID: 12037135.
  • Vera G, Fichna, J, Abalo, R. Cannabinoids and Effects on the Gastrointestinal Tract. A Focus on Motility. Handbook of Cannabis and Related Pathologies Biology, Pharmacology. Diagnosis, and Treatment. 2017. 947-957.
  • Urangaa JA, Vera G, Abalo R. Cannabinoid pharmacology and therapy in gut disorders. Biochem Pharmacol. 2018. 157:134-147.
  • Hinds NM, Ullrich K, Smid SD. Cannabinoid 1 (CB1) receptors coupled to cholinergic motorneurones inhibit neurogenic circular muscle contractility in the human colon. Br J Pharmacol. 2006 May;148(2):191-9. doi: 10.1038/sj.bjp.0706710. PMID: 16520743; PMCID: PMC1617060.
  • Abalo R, Chen C, Vera G, Fichna J, Thakur GA, López-Pérez AE, Makriyannis A, Martín-Fontelles MI, Storr M. In vitro and non-invasive in vivo effects of the cannabinoid-1 receptor agonist AM841 on gastrointestinal motor function in the rat. Neurogastroenterol Motil. 2015 Dec;27(12):1721-35. doi: 10.1111/nmo.12668. Epub 2015 Sep 20. PMID: 26387676; PMCID: PMC4918633.
  • Izzo, A. A., Mascolo, N., Tonini, M., and Capasso, F. (2000). Modulation of peristalsis by cannabinoid CB (1) ligands in the isolated guinea-pig ileum. British journal of pharmacology, 129 (5), 984–990.
  • Szymaszkiewicz A, Zielinska M, Li K, Ramanathan M, Alam S, Hou DR, Fichna J, Storr M. Novel derivatives of 1,2,3-triazole, cannabinoid-1 receptor ligands modulate gastrointestinal motility in mice. Naunyn Schmiedebergs Arch Pharmacol. 2018 Apr;391(4):435-444. doi: 10.1007/s00210-018-1465-9. Epub 2018 Feb 5. PMID: 29404698.
  • Coutts, A. A., Brewster, N., Ingram, T., Razdan, R. K., and Pertwee, R. G. (2000). Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine. British journal of pharmacology, 129 (4), 645–652.
  • Pertwee, R. G., Fernando, S. R., Griffin, G., Abadji, V., and Makriyannis, A. (1995). Effect of phenylmethylsulphonyl fluoride on the potency of anandamide as an inhibitor of electrically evoked contractions in two isolated tissue preparations. European journal of pharmacology, 272 (1), 73–78.
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There are 58 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Clinical Research
Authors

Özge Darakcı 0000-0002-2871-2435

Gökhan Arslan 0000-0003-4186-2478

Erdal Agar 0000-0001-8450-5791

Ayhan Bozkurt 0000-0002-5794-709X

Project Number 220S126
Early Pub Date August 30, 2022
Publication Date August 30, 2022
Submission Date May 27, 2022
Acceptance Date June 13, 2022
Published in Issue Year 2022 Volume: 39 Issue: 3

Cite

APA Darakcı, Ö., Arslan, G., Agar, E., Bozkurt, A. (2022). Role of cannabinoid receptor-2 in small intestinal fasted myoelectric activity of rats. Journal of Experimental and Clinical Medicine, 39(3), 848-856.
AMA Darakcı Ö, Arslan G, Agar E, Bozkurt A. Role of cannabinoid receptor-2 in small intestinal fasted myoelectric activity of rats. J. Exp. Clin. Med. August 2022;39(3):848-856.
Chicago Darakcı, Özge, Gökhan Arslan, Erdal Agar, and Ayhan Bozkurt. “Role of Cannabinoid Receptor-2 in Small Intestinal Fasted Myoelectric Activity of Rats”. Journal of Experimental and Clinical Medicine 39, no. 3 (August 2022): 848-56.
EndNote Darakcı Ö, Arslan G, Agar E, Bozkurt A (August 1, 2022) Role of cannabinoid receptor-2 in small intestinal fasted myoelectric activity of rats. Journal of Experimental and Clinical Medicine 39 3 848–856.
IEEE Ö. Darakcı, G. Arslan, E. Agar, and A. Bozkurt, “Role of cannabinoid receptor-2 in small intestinal fasted myoelectric activity of rats”, J. Exp. Clin. Med., vol. 39, no. 3, pp. 848–856, 2022.
ISNAD Darakcı, Özge et al. “Role of Cannabinoid Receptor-2 in Small Intestinal Fasted Myoelectric Activity of Rats”. Journal of Experimental and Clinical Medicine 39/3 (August 2022), 848-856.
JAMA Darakcı Ö, Arslan G, Agar E, Bozkurt A. Role of cannabinoid receptor-2 in small intestinal fasted myoelectric activity of rats. J. Exp. Clin. Med. 2022;39:848–856.
MLA Darakcı, Özge et al. “Role of Cannabinoid Receptor-2 in Small Intestinal Fasted Myoelectric Activity of Rats”. Journal of Experimental and Clinical Medicine, vol. 39, no. 3, 2022, pp. 848-56.
Vancouver Darakcı Ö, Arslan G, Agar E, Bozkurt A. Role of cannabinoid receptor-2 in small intestinal fasted myoelectric activity of rats. J. Exp. Clin. Med. 2022;39(3):848-56.