A retrospective observational study of autologous peripheral blood stem-cell transplantation and long-term survival outcomes - An institutional experience

Year 2023, Volume: 40 Issue: 3, 437 - 442, 30.09.2023

Mukesh Kumar , Sandeep Jasuja , Krutika Goel , Aditi Mittal , Ramkrishan Ramkrishan , Lalchand Mittal1 , Suman Kapuria , Jaiprakash Yadav

Abstract

Autologous peripheral blood stem cell transplantation (PBSCT) has been employed in patients with various haematological and non-haematological malignancies. The present retrospective study aimed to examine the clinical efficacy and overall long-term survival outcomes of the patients who underwent autologous PBSCT. The clinical data of 49 patients with various haematological and non-haematological malignancies from the Department of Haematology of SMS Hospital from April 2015 to March 2021 were retrospectively analysed. The median age of our patients was 41.5 years. Among all indications, relapsed hodgkins lymphoma (10, 20.4%) and multiple myeloma (27, 55.1%) were reported to be high. The average engraftment was observed to be 11 days with no post-operative complications. The average follow-up period was 2.5 years with a mortality rate of 8.16% (4). Overall, a total of 43 (87.75%) patients showed a complete response with a relapse rate of 12.24% (6). In conclusion, autologous PBSCT can be an effective treatment option with good clinical efficacy, and long term survival outcomes. Our results are comparable to those of many national and international published reports. Overall, the results suggest that with improved management of conditioning-related toxicities and infections, it is possible to develop PBSCT programs in third-world countries and achieve outcomes comparable to those in the international data.

Keywords

Autologous transplantation, peripheral blood stem-cell transplantation, conditioning regimen, retrospective observational study, survival outcomes.

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