Research Article
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Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome

Year 2024, Volume: 41 Issue: 3, 453 - 462, 30.09.2024

Abstract

The predictive value of the C-reactive protein / Prealbumin (CRP/PAB) ratio for the assessment of left atrial (LA) functions in metabolic syndrome (Met-S) remains unclear. We enrolled 100 patients with newly diagnosed Met-S and 53 individuals as a control group. Detailed conventional and tissue Doppler echocardiographic examinations were performed, including measurements of volumes and functional indexes of LA. Mean CRP/PAB ratio values were not found to be different between groups (p=0,107). Mean mitral-A, tricuspid-A, and mitral-a’ velocities were found to be significantly different between groups (p-value for all<0,05). None of the volumetric and functional indexes of LA were found to be different between groups (p-value for all >0,05). After dividing the patients into groups as presenting wleft-right/left ventricular diastolic dysfunction (RVDD- LVDD) or not, again, none of the volumetric and functional indexes of LA were found to be different between groups (p-value for all >0,05). Finally, the CRP/PAB ratio was not found to be correlated with any of the indices of LA in patients with Met-S, while only active emptying volüme of LA was found to be correlated with the CRP/PAB ratio in the control group. We did not find any association between the CRP/PAB ratio and LA functions. To evaluate the predictive value of the CRP/PAB ratio for the assessment of LA functions in Met-S needs further studies with a large cohort population.

References

  • Jahangiry L, Farhangi MA and Rezaei F. Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome. Journal of Health, Population and Nutrition 2017 36:36.
  • Reddy P, Lent-Schochet D, Ramakrishnan N et al. Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes. Clin Chim Acta. 2019 Sep;4 96:35-44.
  • Hong GB, Gao PC, Chen YY et al. High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020:13 581–590.
  • Wang C, Han S, Tong F et al. Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study. Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study. Front. Cardiovasc. Med. 8:684919.
  • Matsunaga T, Miyata H, Sugimura K et al. Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer. Yonago Acta Medica 2020; 63(1): 8–19
  • Xie Q, Zhou Y, Xu Z et al. The ratio of CRP to prealbumin levels predict mortality in patients with hospital-acquired acute kidney injury. BMC Nephrology 2011, 12:30.
  • Yamada T, Haruki S, Minami Y et al. The C-reactive protein to prealbumin ratio on admission and its relationship with outcome in patients hospitalized for acute heart failure. Journal of Cardiology 2021; 78: 308–313.
  • Abhayaratna WP, Seward JB, Appleton CP et al. Left Atrial Size Physiologic Determinants and Clinical Applications. Journal of the American College of Cardiology 2006; June 20, Vol.47: No 12: 2357-63.
  • Kurt M, Tanboga IH, Buyukkaya E et al. Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. Anadolu Kardiyol Derg 2014; 14: 128-33.
  • Yilmaz H, Ozcan KS, Sayar N et al. Metabolic Syndrome Is Associated with Atrial Electrical and Mechanical Dysfunction. Med Princ Pract 2015;24 :147–152.
  • Lang RM, Badano LP, Mor-Avi V et al. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Am Soc Echocardiogr 2015; 28:1-39.
  • Gudul NE, Karabag T, Sayin MR et al. Atrial conduction times and left atrial mechanical functions and their relation with diastolic func¬tion in prediabetic patients. Korean J Intern Med 2017; 32:286-294.
  • Mirhafez SR, Ebrahimi M, Karimian MS et al. Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome: evidence-based study with 7284 subjects. European Journal of Clinical Nutrition (2016) 70, 1298–1304.
  • Xiu S, Chhetri JK, Sun L et al. Association of serum prealbumin with risk of osteoporosis in older adults with type 2 diabetes mellitus: a cross-sectional study. Ther Adv Chronic Dis2019, Vol. 10: 1–10.
  • Ren H, Zhao L, Liu Y et al. The High-Sensitivity C-Reactive Protein to Prealbumin Ratio Predicts Adverse Cardiovascular Events after ST-Elevation Myocardial Infarction. The Heart Surgery Forum 2021 .24 (1). 2020-3307 E153-157.
  • Wang W, Ren D, Wang CS et al. High sensitivity C-reactive protein to prealbumin ratio measurement as a marker of the prognosis in acute coronary syndrome. Scientific Reports. Natureresearch 2019; 9:11583.
  • Parameswaran R and Kalman JM. Left Atrium and Cardiovascular Risk: Does Functionality Matter More Than Size? J Am Heart Assoc. 2018;7: e008930.
  • Lee HC, Shin SJ, Huang JK et al. The role of postprandial very-low-density lipoprotein in the development of atrial remodeling in metabolic syndrome. Lipids in Health and Disease 2020; 19:210.
  • Shigematsu Y, Norimatsu S, Ogimoto A et al. The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients. Hypertension Research (2009) 32, 500–504.
  • Allam SRH, Sheredah AEAR, Al-Deftar M et al. Strain/Strain Rate Imaging of Impaired Left Atrial Function in Patients with Metabolic Syndrome. The Egyptian Journal of Hospital Medicine (April 2019) Vol. 75 (3), Page 2467-2474.
  • Akil MA, Akil E, Bilik MZ et al. The relationship between atrial electromechanical delay and left atrial mechanical function in stroke patients. Anatol J Cardiol 2015; 15: 565-70.
  • Barbier P, Adriano EP, Lucini D, et al. Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”. J. Pers. Med. 2022, 12, 1044.
  • Vukomanovic V, Suzic-Lazic J, Celic V. et al. Is there association between left atrial function and functional capacity in patients with uncomplicated type 2 diabetes? Int J Cardiovasc Imaging. 2020 Jan;36(1):15-22.
  • Gulmez O, Parildar H, Cigerli O, Demirdag N. Assessment of left atrial function in patients with type 2 diabetes mellitus with a disease duration of six months. Cardiovasc J Afr 2017; 29: 82–87.
Year 2024, Volume: 41 Issue: 3, 453 - 462, 30.09.2024

Abstract

References

  • Jahangiry L, Farhangi MA and Rezaei F. Framingham risk score for estimation of 10-years of cardiovascular diseases risk in patients with metabolic syndrome. Journal of Health, Population and Nutrition 2017 36:36.
  • Reddy P, Lent-Schochet D, Ramakrishnan N et al. Metabolic syndrome is an inflammatory disorder: A conspiracy between adipose tissue and phagocytes. Clin Chim Acta. 2019 Sep;4 96:35-44.
  • Hong GB, Gao PC, Chen YY et al. High-Sensitivity C-Reactive Protein Leads to Increased Incident Metabolic Syndrome in Women but Not in Men: A Five-Year Follow-Up Study in a Chinese Population. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2020:13 581–590.
  • Wang C, Han S, Tong F et al. Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study. Predictive Value of the Serum Cystatin C/Prealbumin Ratio in Combination With NT-proBNP Levels for Long-Term Prognosis in Chronic Heart Failure Patients: A Retrospective Cohort Study. Front. Cardiovasc. Med. 8:684919.
  • Matsunaga T, Miyata H, Sugimura K et al. Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer. Yonago Acta Medica 2020; 63(1): 8–19
  • Xie Q, Zhou Y, Xu Z et al. The ratio of CRP to prealbumin levels predict mortality in patients with hospital-acquired acute kidney injury. BMC Nephrology 2011, 12:30.
  • Yamada T, Haruki S, Minami Y et al. The C-reactive protein to prealbumin ratio on admission and its relationship with outcome in patients hospitalized for acute heart failure. Journal of Cardiology 2021; 78: 308–313.
  • Abhayaratna WP, Seward JB, Appleton CP et al. Left Atrial Size Physiologic Determinants and Clinical Applications. Journal of the American College of Cardiology 2006; June 20, Vol.47: No 12: 2357-63.
  • Kurt M, Tanboga IH, Buyukkaya E et al. Relation of presence and severity of metabolic syndrome with left atrial mechanics in patients without overt diabetes: a deformation imaging study. Anadolu Kardiyol Derg 2014; 14: 128-33.
  • Yilmaz H, Ozcan KS, Sayar N et al. Metabolic Syndrome Is Associated with Atrial Electrical and Mechanical Dysfunction. Med Princ Pract 2015;24 :147–152.
  • Lang RM, Badano LP, Mor-Avi V et al. Recommendations for Cardiac Chamber Quantification by Echocardiography in Adults: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Am Soc Echocardiogr 2015; 28:1-39.
  • Gudul NE, Karabag T, Sayin MR et al. Atrial conduction times and left atrial mechanical functions and their relation with diastolic func¬tion in prediabetic patients. Korean J Intern Med 2017; 32:286-294.
  • Mirhafez SR, Ebrahimi M, Karimian MS et al. Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome: evidence-based study with 7284 subjects. European Journal of Clinical Nutrition (2016) 70, 1298–1304.
  • Xiu S, Chhetri JK, Sun L et al. Association of serum prealbumin with risk of osteoporosis in older adults with type 2 diabetes mellitus: a cross-sectional study. Ther Adv Chronic Dis2019, Vol. 10: 1–10.
  • Ren H, Zhao L, Liu Y et al. The High-Sensitivity C-Reactive Protein to Prealbumin Ratio Predicts Adverse Cardiovascular Events after ST-Elevation Myocardial Infarction. The Heart Surgery Forum 2021 .24 (1). 2020-3307 E153-157.
  • Wang W, Ren D, Wang CS et al. High sensitivity C-reactive protein to prealbumin ratio measurement as a marker of the prognosis in acute coronary syndrome. Scientific Reports. Natureresearch 2019; 9:11583.
  • Parameswaran R and Kalman JM. Left Atrium and Cardiovascular Risk: Does Functionality Matter More Than Size? J Am Heart Assoc. 2018;7: e008930.
  • Lee HC, Shin SJ, Huang JK et al. The role of postprandial very-low-density lipoprotein in the development of atrial remodeling in metabolic syndrome. Lipids in Health and Disease 2020; 19:210.
  • Shigematsu Y, Norimatsu S, Ogimoto A et al. The influence of insulin resistance and obesity on left atrial size in Japanese hypertensive patients. Hypertension Research (2009) 32, 500–504.
  • Allam SRH, Sheredah AEAR, Al-Deftar M et al. Strain/Strain Rate Imaging of Impaired Left Atrial Function in Patients with Metabolic Syndrome. The Egyptian Journal of Hospital Medicine (April 2019) Vol. 75 (3), Page 2467-2474.
  • Akil MA, Akil E, Bilik MZ et al. The relationship between atrial electromechanical delay and left atrial mechanical function in stroke patients. Anatol J Cardiol 2015; 15: 565-70.
  • Barbier P, Adriano EP, Lucini D, et al. Determinants of Left Atrial Compliance in the Metabolic Syndrome: Insights from the “Linosa Study”. J. Pers. Med. 2022, 12, 1044.
  • Vukomanovic V, Suzic-Lazic J, Celic V. et al. Is there association between left atrial function and functional capacity in patients with uncomplicated type 2 diabetes? Int J Cardiovasc Imaging. 2020 Jan;36(1):15-22.
  • Gulmez O, Parildar H, Cigerli O, Demirdag N. Assessment of left atrial function in patients with type 2 diabetes mellitus with a disease duration of six months. Cardiovasc J Afr 2017; 29: 82–87.
There are 24 citations in total.

Details

Primary Language English
Subjects Cardiology
Journal Section Research Article
Authors

Yalçın Boduroğlu 0000-0002-6327-8849

Bilal İlanbey 0000-0002-7614-281X

Publication Date September 30, 2024
Submission Date June 7, 2023
Acceptance Date May 23, 2024
Published in Issue Year 2024 Volume: 41 Issue: 3

Cite

APA Boduroğlu, Y., & İlanbey, B. (2024). Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome. Journal of Experimental and Clinical Medicine, 41(3), 453-462.
AMA Boduroğlu Y, İlanbey B. Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome. J. Exp. Clin. Med. September 2024;41(3):453-462.
Chicago Boduroğlu, Yalçın, and Bilal İlanbey. “Investigation of the Relationship Between Comprehensive Echocardiograhic Findings and CRP/Prealbumin Ratio in Patients With Metabolic Syndrome”. Journal of Experimental and Clinical Medicine 41, no. 3 (September 2024): 453-62.
EndNote Boduroğlu Y, İlanbey B (September 1, 2024) Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome. Journal of Experimental and Clinical Medicine 41 3 453–462.
IEEE Y. Boduroğlu and B. İlanbey, “Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome”, J. Exp. Clin. Med., vol. 41, no. 3, pp. 453–462, 2024.
ISNAD Boduroğlu, Yalçın - İlanbey, Bilal. “Investigation of the Relationship Between Comprehensive Echocardiograhic Findings and CRP/Prealbumin Ratio in Patients With Metabolic Syndrome”. Journal of Experimental and Clinical Medicine 41/3 (September 2024), 453-462.
JAMA Boduroğlu Y, İlanbey B. Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome. J. Exp. Clin. Med. 2024;41:453–462.
MLA Boduroğlu, Yalçın and Bilal İlanbey. “Investigation of the Relationship Between Comprehensive Echocardiograhic Findings and CRP/Prealbumin Ratio in Patients With Metabolic Syndrome”. Journal of Experimental and Clinical Medicine, vol. 41, no. 3, 2024, pp. 453-62.
Vancouver Boduroğlu Y, İlanbey B. Investigation of the relationship between comprehensive echocardiograhic findings and CRP/prealbumin ratio in patients with metabolic syndrome. J. Exp. Clin. Med. 2024;41(3):453-62.