Hipertansif Hastalarda Reverse-dipper Kan Basıncı ile Nötrofil Lenfosit Oranı Arasındaki İlişki

Year 2019, Volume: 41 Issue: 3, 203 - 207, 01.07.2019

Müjgan Tek Fatma Ayerden Ebinç Aysun Aybal Kutlugün Fatma Kaplan Efe Serkan Çetin Savaş Çelebi Berkten Berkalp

https://doi.org/10.20515/otd.410269

Abstract

Revers dipper hipertansiyon ve nötrofil/lenfosit
oranı (NLR), kardiyovasküler risk öngördürücüsü olarak araştırılmaktadır. NLR
ve diğer sirkadyen kan basıncı paternleri arasındaki ilişki gösterilmiştir. Bu
çalışmanın amacı hipertansif hastalarda nötrofil lenfosit oranı ile revers
dipper kan basıncı paterni arasındaki ilişkiyi değerlendirmektir. Çalışmaya 144 (66 erkek, 78 kadın)
hipertansif hasta alındı. Kan basıncı paternleri 24 saat ambulatuar kan basıncı
ile değerlendirildi. Nötrofil lenfosit oranı, nötrofil sayısı lenfosit sayısına
bölünerek ölçüldü. Revers dipper hipertansiyonlularda dipper
hipertansiyonlulara göre nötrofil lenfosit oranında anlamlı artış vardı.
(sırasıyla 2.36±1,68 ve 1,81±0,69, p=0,040 ). Nötrofil lenfosit oranı ile
sistolik (r=-0,193;p=0.021 ve diyastolik ( r=-0,160; p=0,057) kan basıncı düşme
oranları arasında negatif korelasyon vardı.
Çalışmamız NLR ve revers dipper patern arasında olası bir ilişki
sunmaktadır ancak nötrofil lenfosit oranını, 
revers dipper paternin  bağımsız
öngörücüsü olarak rapor etmek için daha ileri çalışmalar gereklidir.

Keywords

Nötrofil lenfosit oranı, revers dipper

The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients

Abstract

Reverse dipper hypertension
and  neutrophil to lymphocyte ratio (NLR)
has been investigated as a predictor for cardiovascular risk. The relationship
between NLR and other circadien blood pressure (BP) patterns has been showed.
The aim of this study was to investigate the relation between NLR and BP
reverse dipper pattern in patients with hypertension. 144 hypertensive patients
(66 males, 78 females) were enrolled the study. BP patterns were evaluated with
24-h ambulatory BP monitoring (ABPM). Baseline NLR was measured by dividing
neutrophil count to lymhocyte count. There was significantly increased NLR in
reverse dippers (2,36±1,68 ) than dippers (1,81±0,69) of hypertension (p=0,040
). NLR was negatively correlated with the decline rate of nocturnal systolic BP(r=-0,193;p=0.021)
and diastolic BP( r=-0,160; p=0,057). Our study provides a possible association
between NLR and reverse dipper pattern, but to report NLR as an independent
predictor of reverse dipper pattern further studies are required.

Keywords

NLR, reverse - dipper

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