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Çocukluk Çağı Kanser Tedavisi Tamamlanmış Hastalarda Oral ve Dental Anomalilerin Değerlendirilmesi

Year 2020, Ağız Kanserleri Özel Sayısı, 36 - 42, 28.09.2020
https://doi.org/10.20515/otd.770579

Abstract

Amaç: Bu çalışmanın amacı çocukluk çağı kanser tedavisi tamamlanmış hastaları, ağız diş sağlığı durumları ve dental anomaliler açısından sağlıklı çocuklarla karşılaştırılmalı şekilde değerlendirmektir.
Gereç-Yöntemler: Çalışmaya kanser tedavisi tamamlanmış 50 hasta ve herhangi bir sistemik hastalığı bulunmayan 51 sağlıklı birey olmak üzere toplamda 101 kişi dahil edildi. Hastaların klinik muayenesinde ağızdaki yumuşak ve sert dokular incelendi, mine defektleri, dental bozukluklar, DMFT/dmft, plak indeksi, gingival indeks skorları değerlendirildi. Radyografik muayene ile dişlerin kök gelişimleri, apikal kapanma durumu, diş eksiklikleri kaydedildi.
Elde edilen verilerin analizi IBM SPSS Statistics 21 ile gerçekleştirildi. t testi, tek yönlü varyans analizi (ANOVA) ve Ki-Kare analizleri kullanıldı.
Bulgular: DMFT skoru ortalaması vaka grubunda 3,20 ± 3,33 iken kontrol grubunda 1,98 ± 2,72 idi. İki grup arasında istatistiksel olarak anlamlı farklılık olduğu belirlendi (p=0,047). Silness plak indeksi ve Gingival kanama indeks skoru açısından vaka ve kontrol grupları arasında istatistiksel olarak anlamlı bir fark saptanmamıştır (p>0,05). Gelişimsel dental defektler arasında kısa V şekilli durmuş kök gelişimi 5 yaş altında tedavi alan hastalarda ortalama dört kat fazla görüldü. Mikrodonti saptanan hastaların ise 5 yaş altında tedavi alan grupta, 5 yaş üstünde tedavi alan gruba göre yaklaşık üç kat fazla olduğu görüldü.
Sonuç: Kanser tedavisi almış grupta kontrol grubuna göre ağız hijyeninin daha kötü, DMFT skorlarının daha yüksek olduğu ve 5 yaş altında alınan kanser tedavilerinde bazı dental anomalilerin daha sık olduğu tespit edilmiştir. Bu konuda daha geniş örneklem gruplarında ileri çalışmalara ihtiyaç duyulmaktadır.

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References

  • Nemeth O, Hermann P, Kivovics P, Garami M. Long-term effects of chemotherapy on dental status of children cancer survivors. J Pediatr Hematol Oncol. 2013;30:208-15.
  • Singh N, Scully C, Joyston-Bechal S. Oral complications of cancer therapies: prevention and management. J Clin Oncol. 1996;8:15-24.
  • Steliarova-Foucher E, Kaatsch P, Lacour B, Pompe-Kirn V, Eser S, Miranda A, et al. Quality, comparability and methods of analysis of data on childhood cancer in Europe (1978–1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42:1915-51.
  • Pajari U, Lanning M, Larmas M. Prevalence and location of enamel opacities in children after anti‐neoplastic therapy. Community Dent Oral Epidemiol. 1988;16:222-6.
  • Näsman M, Björk O, Söderhäll S, Ringden O, Dahllöf G. Disturbances in the oral cavity in pediatric long-term survivors after different forms of antineoplastic therapy. Pediatr Dent. 1994;16:217-23.
  • Dickerman JD. The late effects of childhood cancer therapy. Pediatrics.2007;119:554-68.
  • Fromm M, Littman P, Raney RB, Nelson L, Handler S, Diamond G, et al. Late effects after treatment of twenty children with soft tissue sarcomas of the head and neck. Experience at a single institution with a review of the literature. Cancer. 1986;57:2070-6.
  • Hutton A, Bradwell M, English M, Chapple I. The oral health needs of children after treatment for a solid tumour or lymphoma. Int J Paediatr Dent. 2010;20:15-23.
  • Dahllöf G, Barr M, Bolme P, Modéer T, Lönnqvist B, Ringdén O, et al. Disturbances in dental development after total body irradiation in bone marrow transplant recipients. Oral Surg Oral Med Oral Pathol Oral Radiol. 1988;65:41-4.
  • Minicucci EM, Lopes LF, Crocci AJ. Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leukemia Res. 2003;27:45-50.
  • Oğuz A, Çetiner S, Karadeniz C, Alpaslan G, Alpaslan C, Pinarli G. Long‐term effects of chemotherapy on orodental structures in children with non‐Hodgkin's lymphoma. Eur J Oral Sci. 2004;112:8-11.
  • Dahllöf G, Forsberg C, Borgström B. Changes in craniofacial development induced by growth hormone therapy in children treated with bone marrow transplantation. Acta Paediatr. 1994;83:1165-9.

Evaluation of Oral and Dental Anomalies in Patients with Childhood Cancer Treatment

Year 2020, Ağız Kanserleri Özel Sayısı, 36 - 42, 28.09.2020
https://doi.org/10.20515/otd.770579

Abstract

The aim of this study is to evaluate the patients who have completed childhood cancer treatment in comparison with healthy children in terms of oral dental health and dental anomalies. A total of 101 patients, including 50 patients with cancer treatment (case group) and 51 healthy individuals (control group) without any systemic disease, were included in the study. In the clinical examination of the patients, soft and hard tissues in the mouth were examined, enamel defects, dental disorders, DMFT / dmft, plaque index, gingival index scores were evaluated. In the radiographic examination, root development of the teeth, apical closure, tooth deficiencies were recorded. The analysis of the data obtained was performed with IBM SPSS Statistics 21. T-test, one-way analysis of variance (ANOVA) and Chi-Square analysis were used. The mean DMFT score was 3.20 ± 3.33 in the case group and 1.98 ± 2.72 in the control group. There was a statistically significant difference between the two groups (p = 0.047). There was no statistically significant difference between the case and control groups in terms of the Silness plaque index and gingival bleeding index score (p> 0.05). Among the developmental dental defects, the short V-shaped root development was observed on average 4 times more in patients under 5 years of age. The patients with microdontia were found to be about 3 times more in the group under 5 years of age than in the group over 5 years of age. It was found that oral hygiene was worse, DMFT scores were higher in the case group compared to the control group, and some dental anomalies were more common in cancer treatments under 5 years old. Further studies are needed in larger sample groups.

Project Number

-

References

  • Nemeth O, Hermann P, Kivovics P, Garami M. Long-term effects of chemotherapy on dental status of children cancer survivors. J Pediatr Hematol Oncol. 2013;30:208-15.
  • Singh N, Scully C, Joyston-Bechal S. Oral complications of cancer therapies: prevention and management. J Clin Oncol. 1996;8:15-24.
  • Steliarova-Foucher E, Kaatsch P, Lacour B, Pompe-Kirn V, Eser S, Miranda A, et al. Quality, comparability and methods of analysis of data on childhood cancer in Europe (1978–1997): report from the Automated Childhood Cancer Information System project. Eur J Cancer. 2006;42:1915-51.
  • Pajari U, Lanning M, Larmas M. Prevalence and location of enamel opacities in children after anti‐neoplastic therapy. Community Dent Oral Epidemiol. 1988;16:222-6.
  • Näsman M, Björk O, Söderhäll S, Ringden O, Dahllöf G. Disturbances in the oral cavity in pediatric long-term survivors after different forms of antineoplastic therapy. Pediatr Dent. 1994;16:217-23.
  • Dickerman JD. The late effects of childhood cancer therapy. Pediatrics.2007;119:554-68.
  • Fromm M, Littman P, Raney RB, Nelson L, Handler S, Diamond G, et al. Late effects after treatment of twenty children with soft tissue sarcomas of the head and neck. Experience at a single institution with a review of the literature. Cancer. 1986;57:2070-6.
  • Hutton A, Bradwell M, English M, Chapple I. The oral health needs of children after treatment for a solid tumour or lymphoma. Int J Paediatr Dent. 2010;20:15-23.
  • Dahllöf G, Barr M, Bolme P, Modéer T, Lönnqvist B, Ringdén O, et al. Disturbances in dental development after total body irradiation in bone marrow transplant recipients. Oral Surg Oral Med Oral Pathol Oral Radiol. 1988;65:41-4.
  • Minicucci EM, Lopes LF, Crocci AJ. Dental abnormalities in children after chemotherapy treatment for acute lymphoid leukemia. Leukemia Res. 2003;27:45-50.
  • Oğuz A, Çetiner S, Karadeniz C, Alpaslan G, Alpaslan C, Pinarli G. Long‐term effects of chemotherapy on orodental structures in children with non‐Hodgkin's lymphoma. Eur J Oral Sci. 2004;112:8-11.
  • Dahllöf G, Forsberg C, Borgström B. Changes in craniofacial development induced by growth hormone therapy in children treated with bone marrow transplantation. Acta Paediatr. 1994;83:1165-9.
There are 12 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section ORİJİNAL MAKALE
Authors

Ebru Delikan 0000-0003-1624-3392

M.fatih Sagcan 0000-0002-4788-3256

Elvan Caglar Citak 0000-0003-1451-1373

Project Number -
Publication Date September 28, 2020
Published in Issue Year 2020 Ağız Kanserleri Özel Sayısı

Cite

Vancouver Delikan E, Sagcan M, Citak EC. Çocukluk Çağı Kanser Tedavisi Tamamlanmış Hastalarda Oral ve Dental Anomalilerin Değerlendirilmesi. Osmangazi Tıp Dergisi. 2020;42(5):36-42.


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