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Delayed Diagnosis of A Case of Oral Squamous Cell Carcinoma and Review of the Literature

Year 2020, Ağız Kanserleri Özel Sayısı, 222 - 225, 28.09.2020
https://doi.org/10.20515/otd.771958

Abstract

Squamous cell carcinoma is the predominant form of oral cancer and accounts for greater than 90% of malignant pathology. Early detection is an important criterion for achieving high cure rate. Delay in diagnosis consists of either patient delay or professional delay. Case report this article, we present a case report of 65-year-old male patient with oral squamous cell carcinomas with delayed diagnosis. He stated that the complaint of pain in maxillary left posterior region of the jaw for approximately 2 months. The patient's anamnesis revealed that during 10 days period, he had been to medical doctor in university hospital. In intraoral examination, the presence of ulcerated and haemorrhagic areas at the buccal and palatal sides were found. Extraoral examination revealed palpable, tender, non-mobile and firm submandibular and cervical lymph node on the left side. Histopathological examination revealed poorly differentiated squamous cell carcinoma. He refused to surgical treatment. He was treated by chemotherapy and radiotherapy after confirmation by incisional biopsy and died a few months after they. Oral squamous cell carcinoma can sometimes be difficult to early diagnose, So, health professionals and patients need to be aware that non-healing oral lesions, need to be considered as suspicious.

References

  • 1. Ward BB, Helman JI. Squamous Cell Carcinoma of the Oral and Maxillofacial Region. In: Oral and Maxillofacial Surgery: 3rd Edit [Internet]. 2018. p. 670–689. Available from: http://dx.doi.org/10.1016/B978-0-323-41499-9.00071-6
  • 2. Global Cancer Observatory [Internet]. [cited 2020 Apr 25]. Available from: https://gco.iarc.fr/
  • 3. Priebe SL, Aleksejuniene J, Zed C, Dharamsi S, Thinh DH, Hong NT, et al. Oral squamous cell carcinoma and cultural oral risk habits in Vietnam. Int J Dent Hyg. 2010;8(3):159–68.
  • 4. Raman P, Gayathri PS. Dentist’s Delay or Dexterity to Diagnose the Deadly: A Clinico-radiological Series of Oral Malignancies Exhibiting Varied Presentations in the Tamil Nadu Rural Belt. Cureus. 2019;11(2).
  • 5. Scully C, Kirby J. Statement on mouth cancer diagnosis and prevention. Br Dent J. 2014;216(1):37–8.
  • 6. Güneri P, Epstein JB. Late stage diagnosis of oral cancer: Components and possible solutions. Oral Oncol. 2014;50(12):1131–6.
  • 7. Máximo MB, de Mendonça AC, Alves JF, Cortelli SC, Peruzzo DC DP. Peri-implant diseases may be associated with increased time loading and generalized periodontal bone loss: preliminary results. Int J Psychol Res. 2008;34(5):268–73.
  • 8. Peacock ZS, Pogrel MA, Schmidt BL. Exploring the reasons for delay in treatment of oral cancer. J Am Dent Assoc. 2008 Oct;139(10):1346–52.
  • 9. Paleri V, Welch A. Re: Relative importance of diagnostic delays in different head and neck cancers. Clin Otolaryngol. 2009;34(1):78–9.
  • 10. Brouha XDR, Tromp DM, Koole R, Hordijk GJ, Winnubst JAM, de Leeuw JRJ. Professional delay in head and neck cancer patients: Analysis of the diagnostic pathway. Oral Oncol. 2007;43(6):551–6.
  • 11. Yu T, Wood RE, Tenenbaum HC. Delays in diagnosis of head and neck cancers. J Can Dent Assoc (Tor). 2008;74(1).

Geç Tanı Konulan Bir Yassı Hücreli Karsinom Olgusu ve Literatürün Gözden Geçirilmesi

Year 2020, Ağız Kanserleri Özel Sayısı, 222 - 225, 28.09.2020
https://doi.org/10.20515/otd.771958

Abstract

Ağız yassı hücreli karsinomu, ağız kanserlerinin en sık görülen şeklidir ve malign patolojilerin % 90'ından fazlasından sorumludur. Erken teşhis önemlidir. Ağız kanserlerinin tanısında gecikme, hasta, sağlık profesyonelleri veya sistemden kaynaklanabilir. 65 yaşındaki erkek bir hastada ağızda, gecikmiş yassı hücreli karsinom tanısı konulan bir olgu sunulmaktadır. Hasta sol üst çenenin arka bölgesinde yaklaşık 2 aydır süren ağız yarası ve ağrıdan dolayı tıp doktoruna gittiğini ve 10 gün üniversite hastanesinde yattığını belirtmiştir. İntraoral muayenesinde sol üst 8 numaralı dişin bukkal ve palatinal bölgesinde ülserasyonlu ve kanamalı hiperplastik mukoza saptandı. Ekstraoral muayenesinde sol tarafta hassas, fikse ve sert submandibular ve servikal lenf nodları belirlendi. Histopatolojik incelemede az diferansiye yassı hücreli karsinom tanısı geldi. Hasta cerrahi tedavi olmayı reddetti. Kemoterapi ve radyoterapi tedavisi görmeye başladıe bir süre sonra hayatını kaybetti. Ağız yassı hücreli karsinomunun erken teşhis edilmesi zordur. Dolayısıyla, sağlık profesyonelleri ve hastaların iyileşmeyen ağız yaralarına şüpheli yaklaşmaları gerekmektedir.

References

  • 1. Ward BB, Helman JI. Squamous Cell Carcinoma of the Oral and Maxillofacial Region. In: Oral and Maxillofacial Surgery: 3rd Edit [Internet]. 2018. p. 670–689. Available from: http://dx.doi.org/10.1016/B978-0-323-41499-9.00071-6
  • 2. Global Cancer Observatory [Internet]. [cited 2020 Apr 25]. Available from: https://gco.iarc.fr/
  • 3. Priebe SL, Aleksejuniene J, Zed C, Dharamsi S, Thinh DH, Hong NT, et al. Oral squamous cell carcinoma and cultural oral risk habits in Vietnam. Int J Dent Hyg. 2010;8(3):159–68.
  • 4. Raman P, Gayathri PS. Dentist’s Delay or Dexterity to Diagnose the Deadly: A Clinico-radiological Series of Oral Malignancies Exhibiting Varied Presentations in the Tamil Nadu Rural Belt. Cureus. 2019;11(2).
  • 5. Scully C, Kirby J. Statement on mouth cancer diagnosis and prevention. Br Dent J. 2014;216(1):37–8.
  • 6. Güneri P, Epstein JB. Late stage diagnosis of oral cancer: Components and possible solutions. Oral Oncol. 2014;50(12):1131–6.
  • 7. Máximo MB, de Mendonça AC, Alves JF, Cortelli SC, Peruzzo DC DP. Peri-implant diseases may be associated with increased time loading and generalized periodontal bone loss: preliminary results. Int J Psychol Res. 2008;34(5):268–73.
  • 8. Peacock ZS, Pogrel MA, Schmidt BL. Exploring the reasons for delay in treatment of oral cancer. J Am Dent Assoc. 2008 Oct;139(10):1346–52.
  • 9. Paleri V, Welch A. Re: Relative importance of diagnostic delays in different head and neck cancers. Clin Otolaryngol. 2009;34(1):78–9.
  • 10. Brouha XDR, Tromp DM, Koole R, Hordijk GJ, Winnubst JAM, de Leeuw JRJ. Professional delay in head and neck cancer patients: Analysis of the diagnostic pathway. Oral Oncol. 2007;43(6):551–6.
  • 11. Yu T, Wood RE, Tenenbaum HC. Delays in diagnosis of head and neck cancers. J Can Dent Assoc (Tor). 2008;74(1).
There are 11 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section DERLEME
Authors

Olgun Topal 0000-0003-3550-8739

Publication Date September 28, 2020
Published in Issue Year 2020 Ağız Kanserleri Özel Sayısı

Cite

Vancouver Topal O. Geç Tanı Konulan Bir Yassı Hücreli Karsinom Olgusu ve Literatürün Gözden Geçirilmesi. Osmangazi Tıp Dergisi. 2020;42(5):222-5.


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