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Kronik Santral Seröz Koryoretinopati Hastalarında Geniş Açılı Dijital Fundus Kamera ile Otofloresan Değişikliklerinin Değerlendirilmesi

Year 2022, Volume: 44 Issue: 6, 755 - 760, 28.11.2022
https://doi.org/10.20515/otd.1092900

Abstract

Purpose: To evaluate the autofluorescence variations and localisation in wide-angle digital fundus camera images of patients with chronic central serous chorioretinopathy (CSCR).
Methods: A retrospective scan was made of the images of patients diagnosed with chronic CSCR with wide-angle digital fundus angiography and applied at the same time with autofluorescence imaging. The ultra wide area autofluorescence images of 46 patients were examined. The retina was separated as zone 1, zone 2, and zone 3 in respect of disease involvement, and zone 3 represented the peripheral retina. The images of the patients were recorded as hyperautofluorescence (punctate, diffuse) or hypo-autofluorescence (granular, confluent) in respect of the type of autofluorescence involvement.
Results: After the exclusion of 2 patients because peripheral images could not be clearly selected, the study evaluations were made of 44 eyes of 44 patients. In the result of the examination with wide-angle digital fundus autofluorescence imaging, there was seen to be zone 2 involvement in the 4 quadrants of inferior, nasal, temporal and superior. Peripheral retinal involvement in zone 3 was seen in a total of 7 (15.9%) patients in the form of inferior gravitational defect, in 6 (13.6%) patients together with zones 1 and 2, and in 1 (2.3%) patient together with zone 2. Hyperautofluorescence was determined in 39 (88.6%) patients and hypo-autofluorescence in 5 (11.4%). The involvement frequency was determined as zone 1+2 in 19 (43.2%) patients, followed by zone 1 involvement alone in 16 (36.4%) patients.
Conclusions: While zone 3 peripheral retina involvement was seen only in the form of inferior gravitational defect, zone 2 involvement was determined in 4 quadrants. As the type of autofluorescence, hyperautofluorescence was determined at the high rate of approximately 90%. These results show that CSCR patients identified as zone 2 should be evaluated in respect of autofluorescence in all the quadrants, while disease involvement is only in the inferior of the peripheral retina because of gravity, and hyperautofluorescence is seen very often in CSCR.

Supporting Institution

Yok

References

  • 1. Wang M, Munch IC, Hasler PW, et al. Central serous chorioretinopathy. Acta Ophthalmol 2008;86:126-145.
  • 2. Nicholson B, Noble J, Forooghian F, Meyerle C. Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol. 2013;58:103-126.
  • 3. Spaide RF, Goldbaum M,Wong DWK et al. Serous Detachment of the retina. Retina 2003;23: 820-846
  • 4. Ciardella AP, Borodoker N, Costa DLL et al. The expanding clinical spectrum of central serous choriorethinopathy. Comp Ophthalmol Update 2003;4: 71-84
  • 5. Ko HU: An experimental study of the nature of Masuda's chorioretinitis: III. A study of the relationship existing between chorioretinitis centralis photodynamica and the function of the kidney. Acta Soc Ophthalmol Jpn 1934; 38: 1060-1073.
  • 6. Ryan SJ. Central serous chorioretinopathy. Retina 3rd edn. 2001;2:1153- 1181
  • 7. Tittl MK, Spaide RF, Wong D.: Systemic findings associated with central serous chorioretinopathy. Am J Opthalmol. 1999; 128: 63- 68.
  • 8. Michael JC1, Pak J, Pulido J, de Venecia G.Central serous chorioretinopathy associated with administration of sympathomimetic agents. Am J Ophthalmol. 2003 Jul;136(1):182-5.
  • 9. Haimovici R, Rumelt S, Melby J. Endocrine abnormalities in patients with central serous chorioretinopathy. Ophthalmology 2003; 110: 698–703
  • 10. Gass JDM. Pathogenesis of disciform detachment of the neuroepithelium, idiopathic central serous choroidopathy. Am J Ophthalmol. 1967;63:587-615.
  • 11. Hee MR, Puliafito CA, Wong C et al. Optical coherence tomography of central serous chorioretinopathy. Am J Ophthalmol. 1995;120:65-74.
  • 12. Wang M, Sander B, Lund-Andersen H and Larsen M. Detection of shallow detachments in central serous chorioretinopathy. Acta Ophthalmologica Scandinavica. 1999;77:402-5.
  • 13. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG and Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophtolmol Vis Sci. 1995;36:718–29.
  • 14. Von Rückmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995;79:407-12.
  • 15. Dinc UA, Tatlipinar S, Yenerel M, Görgün E, Ciftci F. Fundus autofluorescence in acute and chronic central serous chorioretinopathy. Clin Exp Optom. 2011;94:452-7
  • 16. Eandi CM, Ober M, Iranmanesh R, Peiretti R, Yanuzzi LA. Acute central serous retinopathy and fundus autofluorescent. Retina. 2005;25:989–93.
  • 17. Yaylacıoğlu FT, Gürelik G. Santral seröz koryoretinopati. Ret-Vit. 2010;18:2:85-111.
  • 18. Lee, W. J., J. H. Lee, and B. R. Lee. "Fundus autofluorescence imaging patterns in central serous chorioretinopathy according to chronicity." Eye 30.10 (2016): 1336.
  • 19. Spaide R.: Autofluorescence from the outer retina and subretinal space: hypothesis and review. Retina. 2008;28:5-35. 20. Ayata, Ali, et al. "Kronik santral seröz koriyoretinopatide optik koherens tomografi ve otofloresans bulguları." Ret-Vit 17 (2009): 9-13.
  • 21. Pang CE, Shah VP, Sarraf D, & Freund KB. Ultra-widefield imaging with autofluorescence and indocyanine green angiography in central serous chorioretinopathy. American journal of ophthalmology. 2014;158(2):362-371.
  • 22. Küçükiba, K., Erol, N., & Bilgin, M. (2020). Evaluation of Peripheral Retinal Changes on Ultra-widefield Fundus Autofluorescence Images of Patients with Age-related Macular Degeneration. Turk J Ophthalmol.2020; 50: 6-14.
  • 23. Aggio FB, Roisman L, Melo GB, Lavinsky D, Cardillo JA, Farah ME. Clinical factors related to visual outcome in central serous chorioretinopathy. Retina 2010; 30(7): 1128–1134.
  • 24. Chen SN, Hwang JF, Tseng LF, Lin CJ. Subthreshold diode micropulse photocoagulation for the treatment of chronic central serous chorioretinopathy with juxtafoveal leakage. Ophthalmology 2008; 115(12): 2229–2234.
  • 25. Spaide RF, Campeas L, Haas A, Yannuzzi LA, Fisher YL, Guyer DR et al. Central serous chorioretinopathy in younger and older adults. Ophthalmology 1996; 103(12): 2070–2079
  • 26. Framme C, Walter A, Gabler B, et al.: Fundus autofluorescence in acute and chronic-recurrent central serous chorioretinopathy. Acta Ophthalmol Scand. 2005;83:161-167.

An Evaluation of the Autofluorescence Changes with Wide-Angle Digital Fundus Camera in Chronic Central Serous Chorioretinopathy Patients

Year 2022, Volume: 44 Issue: 6, 755 - 760, 28.11.2022
https://doi.org/10.20515/otd.1092900

Abstract

To evaluate the autofluorescence variations and localisation in wide-angle digital fundus camera images of patients with chronic central serous chorioretinopathy (CSCR). A retrospective scan was made of the images of patients diagnosed with chronic CSCR with wide-angle digital fundus angiography and applied at the same time with autofluorescence imaging. The ultra wide area autofluorescence images of 46 patients were examined. The retina was separated as zone 1, zone 2, and zone 3 in respect of disease involvement, and zone 3 represented the peripheral retina. The images of the patients were recorded as hyperautofluorescence (punctate, diffuse) or hypo-autofluorescence (granular, confluent) in respect of the type of autofluorescence involvement. After the exclusion of 2 patients because peripheral images could not be clearly selected, the study evaluations were made of 44 eyes of 44 patients. The mean duration of the disease was found to be 2.7 years. In the result of the examination with wide-angle digital fundus autofluorescence imaging, there was seen to be zone 2 involvement in the 4 quadrants of inferior, nasal, temporal and superior. Peripheral retinal involvement in zone 3 was seen in a total of 7 (15.9%) patients in the form of inferior gravitational defect, in 6 (13.6%) patients together with zones 1 and 2, and in 1 (2.3%) patient together with zone 2. Hyperautofluorescence was determined in 39 (88.6%) patients and hypo-autofluorescence in 5 (11.4%). The involvement frequency was determined as zone 1+2 in 19 (43.2%) patients, followed by zone 1 involvement alone in 16 (36.4%) patients. Common autofluorescence type was detected as hyperautofluorescence in chronic CSCR patients with a high rate of approximately 90%. It has also been shown that in some patients, the disease may also affect the inferior peripheral retina due to the effect of gravity. 

References

  • 1. Wang M, Munch IC, Hasler PW, et al. Central serous chorioretinopathy. Acta Ophthalmol 2008;86:126-145.
  • 2. Nicholson B, Noble J, Forooghian F, Meyerle C. Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol. 2013;58:103-126.
  • 3. Spaide RF, Goldbaum M,Wong DWK et al. Serous Detachment of the retina. Retina 2003;23: 820-846
  • 4. Ciardella AP, Borodoker N, Costa DLL et al. The expanding clinical spectrum of central serous choriorethinopathy. Comp Ophthalmol Update 2003;4: 71-84
  • 5. Ko HU: An experimental study of the nature of Masuda's chorioretinitis: III. A study of the relationship existing between chorioretinitis centralis photodynamica and the function of the kidney. Acta Soc Ophthalmol Jpn 1934; 38: 1060-1073.
  • 6. Ryan SJ. Central serous chorioretinopathy. Retina 3rd edn. 2001;2:1153- 1181
  • 7. Tittl MK, Spaide RF, Wong D.: Systemic findings associated with central serous chorioretinopathy. Am J Opthalmol. 1999; 128: 63- 68.
  • 8. Michael JC1, Pak J, Pulido J, de Venecia G.Central serous chorioretinopathy associated with administration of sympathomimetic agents. Am J Ophthalmol. 2003 Jul;136(1):182-5.
  • 9. Haimovici R, Rumelt S, Melby J. Endocrine abnormalities in patients with central serous chorioretinopathy. Ophthalmology 2003; 110: 698–703
  • 10. Gass JDM. Pathogenesis of disciform detachment of the neuroepithelium, idiopathic central serous choroidopathy. Am J Ophthalmol. 1967;63:587-615.
  • 11. Hee MR, Puliafito CA, Wong C et al. Optical coherence tomography of central serous chorioretinopathy. Am J Ophthalmol. 1995;120:65-74.
  • 12. Wang M, Sander B, Lund-Andersen H and Larsen M. Detection of shallow detachments in central serous chorioretinopathy. Acta Ophthalmologica Scandinavica. 1999;77:402-5.
  • 13. Delori FC, Dorey CK, Staurenghi G, Arend O, Goger DG and Weiter JJ. In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophtolmol Vis Sci. 1995;36:718–29.
  • 14. Von Rückmann A, Fitzke FW, Bird AC. Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Br J Ophthalmol. 1995;79:407-12.
  • 15. Dinc UA, Tatlipinar S, Yenerel M, Görgün E, Ciftci F. Fundus autofluorescence in acute and chronic central serous chorioretinopathy. Clin Exp Optom. 2011;94:452-7
  • 16. Eandi CM, Ober M, Iranmanesh R, Peiretti R, Yanuzzi LA. Acute central serous retinopathy and fundus autofluorescent. Retina. 2005;25:989–93.
  • 17. Yaylacıoğlu FT, Gürelik G. Santral seröz koryoretinopati. Ret-Vit. 2010;18:2:85-111.
  • 18. Lee, W. J., J. H. Lee, and B. R. Lee. "Fundus autofluorescence imaging patterns in central serous chorioretinopathy according to chronicity." Eye 30.10 (2016): 1336.
  • 19. Spaide R.: Autofluorescence from the outer retina and subretinal space: hypothesis and review. Retina. 2008;28:5-35. 20. Ayata, Ali, et al. "Kronik santral seröz koriyoretinopatide optik koherens tomografi ve otofloresans bulguları." Ret-Vit 17 (2009): 9-13.
  • 21. Pang CE, Shah VP, Sarraf D, & Freund KB. Ultra-widefield imaging with autofluorescence and indocyanine green angiography in central serous chorioretinopathy. American journal of ophthalmology. 2014;158(2):362-371.
  • 22. Küçükiba, K., Erol, N., & Bilgin, M. (2020). Evaluation of Peripheral Retinal Changes on Ultra-widefield Fundus Autofluorescence Images of Patients with Age-related Macular Degeneration. Turk J Ophthalmol.2020; 50: 6-14.
  • 23. Aggio FB, Roisman L, Melo GB, Lavinsky D, Cardillo JA, Farah ME. Clinical factors related to visual outcome in central serous chorioretinopathy. Retina 2010; 30(7): 1128–1134.
  • 24. Chen SN, Hwang JF, Tseng LF, Lin CJ. Subthreshold diode micropulse photocoagulation for the treatment of chronic central serous chorioretinopathy with juxtafoveal leakage. Ophthalmology 2008; 115(12): 2229–2234.
  • 25. Spaide RF, Campeas L, Haas A, Yannuzzi LA, Fisher YL, Guyer DR et al. Central serous chorioretinopathy in younger and older adults. Ophthalmology 1996; 103(12): 2070–2079
  • 26. Framme C, Walter A, Gabler B, et al.: Fundus autofluorescence in acute and chronic-recurrent central serous chorioretinopathy. Acta Ophthalmol Scand. 2005;83:161-167.
There are 25 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section ORİJİNAL MAKALE
Authors

Mustafa Değer Bilgeç 0000-0002-9972-2147

Erdoğan Yaşar 0000-0001-5129-9397

Nazmiye Erol 0000-0002-8273-6040

Publication Date November 28, 2022
Published in Issue Year 2022 Volume: 44 Issue: 6

Cite

Vancouver Bilgeç MD, Yaşar E, Erol N. An Evaluation of the Autofluorescence Changes with Wide-Angle Digital Fundus Camera in Chronic Central Serous Chorioretinopathy Patients. Osmangazi Tıp Dergisi. 2022;44(6):755-60.


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