Tedaviye Dirençli Temporal Lob Epilepsili Olgularda Serum ve Bos’ta Otoantikorlar: Olgu Serisi

Year 2023, Volume: 45 Issue: 1, 125 - 129, 23.01.2023

Sibel Canbaz Kabay Erdem Tüzün Gönül Akdağ Mustafa Çetiner Selahattin Ayas Handan Işın Özışık Karaman Fatma Akkoyun Arıkan

https://doi.org/10.20515/otd.1167517

Abstract

Nöbet önleyici ilaca(NÖİ) dirençli temporal lob epilepsili hastaların serum ve beyin omurilik sıvısı (BOS) analizinde nöronal antikor varlığını araştırmayı amaçladık. İlaca dirençli temporal lob epilepsisi tanısı ile izlenen, lomber ponksiyonu kabul eden 8 hastayı değerlendirdik. İlaca dirençli temporal lob epilepsisi nedeniyle takip ettiğimiz ve otoimmün epilepsi şüphesi duyduğumuz olgularda nöronal antikorları ve klinik özellikleri araştırdık. Tüm hastalarda hem serum hem de BOS'ta nöronal otoantikorlar negatif bulundu. BOS ve serum incelemelerinde nöronal antikorlar saptanmasa da bu durum çalışma grubumuzda epilepsi başlangıç yaşının erken olması ile ilişkili olabilir. Subakut bir klinik, nöbet sıklığının alışılmadık derecede yüksek olması, nöbetlerin çeşitliliği ve değişkenliği, NÖİ’lara direnç, kişide veya ailesinde otoimmün hastalık varlığı, kanser öyküsü veya viral prodrom varlığı, santral sinir sistemi inflamasyonun gösterilmesi, nöral antikorların varlığında Otoimmün epilepsi ayırıcı tanıda düşünülmelidir.

Keywords

Temporal lob epilepsisi;, beyin omurilik sıvısı nöronal antikoru, serum nöronal antikor

Supporting Institution

Kütahya Dumlupınar Üniversitesi BİLİMSEL ARAŞTIRMA PROJELERİ BİRİMİ

Project Number

2014 - 29

Cerebrospinal Fluid and Serum Autoantıbodıes in Drug-Resistant Temporal Lobe Epilepsıes: Case Series

Abstract

We aimed to investigate the presence of neuronal antibodies in serum and cerebrospinal fluid(CSF) analysis of patients with drug resistant temporal lobe epilepsy. We evaluated 8 patients who accepted lumbar puncture with a diagnosis of drug resistant temporal lobe epilepsy. Neuronal autoantibodies were found to be negative in both serum and CSF in all patients. We investigated neuronal antibodies and clinical features in cases who were followed up for drug-resistant temporal lobe epilepsy and suspected of autoimmune epilepsy. Although neuronal antibodies were not detected in CSF and serum examinations, this may be related to the early age of onset in our study group. Autoimmune epilepsy should be considered among the differantial diagnosis with a subacute clinic, unusually high seizure frequency, variety and variability of seizures, resistance to antiseizure medications(ASMs), presence of an autoimmune disease in the person or his/her family, history of cancer or viral prodroma, demonstration of CNS inflammation and detection of neural antibodies.

Keywords

Temporal lobe epilepsy, cerebrospinal fluid neuronal antibody,, serum neuronal antibody,

Project Number

2014 - 29

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