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Jeneralize Eklem Hipermobilitesi Olan ve Olmayan Üniversite Kız Öğrencilerinin Sağlıkla İlişkili Fiziksel Uygunluğu: Bir Vaka Kontrol Çalışması

Year 2024, Volume: 46 Issue: 3, 463 - 474, 27.05.2024
https://doi.org/10.20515/otd.1463720

Abstract

Jeneralize eklem hipermobilitesinin (JEH) sağlıkla ilişkili fiziksel uygunluk üzerindeki etkisini değerlendirmek. Katılımcılar: 18-23 yaş arası kadın üniversite öğrencileri. Sağlıkla ilgili fiziksel uygunluk açısından kardiyorespiratuar fitness (maksimum bisiklet ergometre testleri, altı dakika yürüme (6DY) testi), solunum fonksiyon testleri ve solunum kas gücü (maksimum inspiratuar ve ekspiratuar basınç) (MİP ve MEP), vücut kompozisyonu (biyoelektrik empedans analizleri), esneklik (otur ve eriş testi (OET), kas gücü ve dayanıklılık (izometrik ve izokinetik testler) değerlendirildi. Ortalama maksimum oksijen tüketimi (VO2max) (23,6’ya karşı 21,8, p=0,049), metabolik eşdeğer (MET) (6,7 ’ya karşı 6,3, p=0,049), W/kg (1,6 ’ya karşı 1,5, p=0,035) ve OET skorları (23,3 ’ya karşı 18.7, p=0.016) asemptomatik JEH'li 39 öğrencide JEH olmayan 42 öğrenciye göre daha yüksekti. 6DY mesafesi, zorlu vital kapasite (FVC), birinci saniye zorlu ekspirasyon volümü (FEV1), MİP, MEP, vücut kompozisyonu, kas gücü ve dayanıklılık açısından gruplar arasında anlamlı fark bulunamadı (p>0,05). Jeneralize eklem hipermobilitesi olan kadınlar, hipermobilitesi olmayanlarla aynı veya hatta daha yüksek düzeyde fiziksel uygunluk kapasitesine sahiptir.

References

  • 1. Castori M, Tinkle B, Levy H, Grahame R, Malfait F, Hakim A. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet. 2017 ;175(1):148-157.
  • 2. Hakim AJ, Cherkas LF, Grahame R, Spector TD, MacGregor AJ. The genetic epidemiology of joint hypermobility: a population study of female twins. Arthritis Rheum. 2004;50(8):2640-4.
  • 3. Tuna F, Doğanlar ZB, Özdemir H, Demirbag Kabayel D, Doğanlar O. Ehlers-Danlos syndrome-related genes and serum strontium, zinc, and lithium levels in generalized joint hypermobility: a case-control study. Connect Tissue Res. 2021 ;62(2):215-225.
  • 4. TUNA F. Prevalence of joint hypermobility, hypermobility spectrum disorder and hypermobile Ehlers-Danlos syndrome in a university population: an observational study. Eur Res J. March 2020;6(2):120-129.
  • 5. Can S, Tuna F. The impact of generalized joint hypermobility on eating behavior of students: A case-control study. J Am Coll Health. 2022 14:1-6.
  • 6. Toriola, O. M., & Monyeki, M. A. Health-related fitness, body composition and physical activity status among adolescent learners: the PAHL study: health and fitness. African Journal for Physical Health Education, Recreation and Dance, 2012;18, 795-811.
  • 7. Oren, H., & Aytemir, K. . Heart rate recovery: clinical application and methods (Kalp Hızı Toparlanma İndeksi: Klinik Kullanım ve Yöntemler). Turk J Arrhythm Pacing Electrophysiol, 2008;6, 141-150.
  • 8. Dimitriadis Z, Kapreli E, Konstantinidou I, Oldham J, Strimpakos N. Test/retest reliability of maximum mouth pressure measurements with the MicroRPM in healthy volunteers. Respir Care. 2011 Jun;56(6):776-82.
  • 9. Juul-Kristensen B, Røgind H, Jensen DV, Remvig L. Inter-examiner reproducibility of tests and criteria for generalized joint hypermobility and benign joint hypermobility syndrome. Rheumatology (Oxford). 2007 ;46(12):1835-41.
  • 10. Grahame R, Bird HA, Child A. The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol. 2000 ;27(7):1777-9.
  • 11. Beighton P, Solomon L, Soskolne CL. Articular mobility in an African population. Ann Rheum Dis. 1973 ;32(5):413-8.
  • 12. Dittmar M. Reliability and variability of bioimpedance measures in normal adults: effects of age, gender, and body mass. Am J Phys Anthropol. 2003 ;122(4):361-70.
  • 13. Mueller WH, Malina RM. Relative reliability of circumferences and skinfolds as measures of body fat distribution. Am J Phys Anthropol. 1987 ;72(4):437-9.
  • 14. Szulc P, Bartkowiak P, Boch-Kmieciak J, Lewandowski J, Owczarkowska E. The eurofit sit and reach suppleness test competence of ballet school students. Trends in sport sciences. 2013; 2(20); 101-106.
  • 15. Cuberek R, Machová I, Lipenská M. Reliability of V sit-and-reach test used for flexibility self-assessment in females. Acta Gymnica. 2013;43(1):35-39.
  • 16. Mathiowetz V, Weber K, Volland G, Kashman N. Reliability and validity of grip and pinch strength evaluations. The Journal of hand surgery. 1984;9(2):222-226.
  • 17. Stark T, Walker B, Phillips JK, Fejer R, Beck R. Hand-held dynamometry correlation with the gold standard isokinetic dynamometry: a systematic review. PM&R. 2011;3(5):472-479.
  • 18. Andrews AW, Thomas MW, Bohannon RW. Normative values for isometric muscle force measurements obtained with hand-held dynamometers. Physical therapy. 1996;76(3):248-259.
  • 19. Bohannon RW. Reference values for extremity muscle strength obtained by hand-held dynamometry from adults aged 20 to 79 years. Archives of physical medicine and rehabilitation. 1997;78(1):26-32.
  • 20. Kannus P. Isokinetic evaluation of muscular performance. International journal of sports medicine. 1994;15(S 1):S11-S18.
  • 21. Sahin N, Baskent A, Ugurlu H, Berker E. Isokinetic evaluation of knee extensor/flexor muscle strength in patients with hypermobility syndrome. Rheumatology international. 2008;28:643-648.
  • 22. Hayashi K, Miyachi M, Seno N, et al. Variations in carotid arterial compliance during the menstrual cycle in young women. Experimental physiology. 2006;91(2):465-472.
  • 23. Yamamoto K, Kawano H, Gando Y, et al. Poor trunk flexibility is associated with arterial stiffening. American Journal of Physiology-Heart and Circulatory Physiology. 2009;
  • 24. Yazici M, Ataoglu S, Makarc S, et al. The relationship between echocardiographic features of mitral valve and elastic proporties of aortic wall and Beighton hypermobility score in patients with mitral valve prolapse. Japanese Heart Journal. 2004;45(3):447-460.
  • 25. Handler CE, Child A, Light N, Dorrance DE. Mitral valve prolapse, aortic compliance, and skin collagen in joint hypermobility syndrome. Heart. 1985;54(5):501-508.
  • 26. Petersen JW, Douglas JY. Tenascin-X, collagen, and Ehlers–Danlos syndrome: Tenascin-X gene defects can protect against adverse cardiovascular events. Medical hypotheses. 2013;81(3):443-447.
  • 27. Binder J, Bailey KR, Seward JB, et al. Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. American journal of hypertension. 2006;19(10):1019-1024.
  • 28. Boreham CA, Ferreira I, Twisk JW, Gallagher AM, Savage MJ, Murray LJ. Cardiorespiratory fitness, physical activity, and arterial stiffness: the Northern Ireland Young Hearts Project. Hypertension. 2004;44(5):721-726.
  • 29. Varol BK, ŞIRAYDER U, Sandal M, Tuncer D. The effect of generalized joint hypermobility on functional capacity, pulmonary function, respiratory muscle strength, and chest expansion in healthy young adults. Journal of Health Sciences and Medicine. 6(2):300-306.
  • 30. Hakim A, O'Callaghan C, De Wandele I, Stiles L, Pocinki A, Rowe P. Cardiovascular autonomic dysfunction in Ehlers–Danlos syndrome—hypermobile type. Wiley Online Library; 2017:168-174.
  • 31. Roma M, Marden CL, De Wandele I, Francomano CA, Rowe PC. Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome. Autonomic Neuroscience. 2018;215:89-96.
  • 32. Clinch J, Deere K, John T, Clarke E. Epidemiology of generalised joint laxity in 14 year old children from the UK: a population-based evaluation. Pediatric Rheumatology. 2012;10(1):1-1.
  • 33. Engelbert RH, van Bergen M, Henneken T, Helders PJ, Takken T. Exercise tolerance in children and adolescents with musculoskeletal pain in joint hypermobility and joint hypomobility syndrome. Pediatrics. 2006;118(3):e690-e696.
  • 34. Ewertowska P, Trzaskoma Z, Sitarski D, Gromuł B, Haponiuk I, Czaprowski D. Muscle strength, muscle power and body composition in college-aged young women and men with Generalized Joint Hypermobility. Plos one. 2020;15(7):e0236266.
  • 35. Massy-Westropp N, Toubia C. Hypermobility as measured by the Beighton hypermobility test is not predictive of hand grip strength in young adults. Journal of Musculoskeletal Research. 2013;16(01):1350006.
  • 36. Juul-Kristensen B, Hansen H, Simonsen EB, et al. Knee function in 10-year-old children and adults with Generalised Joint Hypermobility. The Knee. 2012;19(6):773-778.
  • 37. Jindal P, Narayan A, Ganesan S, MacDermid JC. Muscle strength differences in healthy young adults with and without generalized joint hypermobility: a cross-sectional study. BMC sports science, medicine and rehabilitation. 2016;8(1):1-9.
  • 38. Scheper M, Engelbert R, Rameckers E, Verbunt J, Remvig L, Juul-Kristensen B. Children with generalised joint hypermobility and musculoskeletal complaints: state of the art on diagnostics, clinical characteristics, and treatment. BioMed research international. 2013;2013
  • 39. Massy-Westropp C, Massy-Westropp N, Wechalekar H. Normative Values for Pinch Strength—Relationship With Joint Hypermobility as Measured With the Beighton Criteria. Journal of Hand Surgery Global Online. 2023;5(3):272-276.
  • 40. Jensen BR, Olesen AT, Pedersen MT, et al. Effect of generalized joint hypermobility on knee function and muscle activation in children and adults. Muscle & nerve. 2013;48(5):762-769.

The Health-Related Physical Fitness of University Female Students with and without Generalized Joint Hypermobility: A Case-Control Study

Year 2024, Volume: 46 Issue: 3, 463 - 474, 27.05.2024
https://doi.org/10.20515/otd.1463720

Abstract

To evaluate the effect of generalized joint hypermobility (GJH) on health-related physical fitness. Female university students between the ages of 18-23. Cardiorespiratory fitness (maximal cycling ergometer tests, six-minute walking (6MW) tests), respiratory function tests, respiratory muscle strength (maximal inspiratory and expiratory pressure) (MIP and MEP), body composition (bioelectrical impedance analyses), flexibility (sit and reach tests (SRT), muscle strength and endurance (isometric and isokinetic tests) were evaluated for health-related physical fitness. The mean value of maximal oxygen uptake (VO2max) (23.6 vs. 21.8, p=.049), metabolic equivalent for task (MET) (6.7 vs. 6.3, p=0.049), W/kg (1.6 vs. 1.5, p=0.035), and SRT scores (23.3 vs. 18.7, p=0.016) were higher in 39 students with asymptomatic GJH compared to 42 non-GJH students. No significant differences found between groups for 6MW distance, forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), MIP, MEP, body composition, muscle strength, and endurance (p>.05). Females with generalized joint hypermobility have the same or even higher levels of physical fitness capacity as those without the hypermobility.

Supporting Institution

This research was supported by the Scientific Research Committee of the Trakya University Research Project Foundation (Project Number TÜBAP-2017/118), Edirne/Turkey.

References

  • 1. Castori M, Tinkle B, Levy H, Grahame R, Malfait F, Hakim A. A framework for the classification of joint hypermobility and related conditions. Am J Med Genet C Semin Med Genet. 2017 ;175(1):148-157.
  • 2. Hakim AJ, Cherkas LF, Grahame R, Spector TD, MacGregor AJ. The genetic epidemiology of joint hypermobility: a population study of female twins. Arthritis Rheum. 2004;50(8):2640-4.
  • 3. Tuna F, Doğanlar ZB, Özdemir H, Demirbag Kabayel D, Doğanlar O. Ehlers-Danlos syndrome-related genes and serum strontium, zinc, and lithium levels in generalized joint hypermobility: a case-control study. Connect Tissue Res. 2021 ;62(2):215-225.
  • 4. TUNA F. Prevalence of joint hypermobility, hypermobility spectrum disorder and hypermobile Ehlers-Danlos syndrome in a university population: an observational study. Eur Res J. March 2020;6(2):120-129.
  • 5. Can S, Tuna F. The impact of generalized joint hypermobility on eating behavior of students: A case-control study. J Am Coll Health. 2022 14:1-6.
  • 6. Toriola, O. M., & Monyeki, M. A. Health-related fitness, body composition and physical activity status among adolescent learners: the PAHL study: health and fitness. African Journal for Physical Health Education, Recreation and Dance, 2012;18, 795-811.
  • 7. Oren, H., & Aytemir, K. . Heart rate recovery: clinical application and methods (Kalp Hızı Toparlanma İndeksi: Klinik Kullanım ve Yöntemler). Turk J Arrhythm Pacing Electrophysiol, 2008;6, 141-150.
  • 8. Dimitriadis Z, Kapreli E, Konstantinidou I, Oldham J, Strimpakos N. Test/retest reliability of maximum mouth pressure measurements with the MicroRPM in healthy volunteers. Respir Care. 2011 Jun;56(6):776-82.
  • 9. Juul-Kristensen B, Røgind H, Jensen DV, Remvig L. Inter-examiner reproducibility of tests and criteria for generalized joint hypermobility and benign joint hypermobility syndrome. Rheumatology (Oxford). 2007 ;46(12):1835-41.
  • 10. Grahame R, Bird HA, Child A. The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). J Rheumatol. 2000 ;27(7):1777-9.
  • 11. Beighton P, Solomon L, Soskolne CL. Articular mobility in an African population. Ann Rheum Dis. 1973 ;32(5):413-8.
  • 12. Dittmar M. Reliability and variability of bioimpedance measures in normal adults: effects of age, gender, and body mass. Am J Phys Anthropol. 2003 ;122(4):361-70.
  • 13. Mueller WH, Malina RM. Relative reliability of circumferences and skinfolds as measures of body fat distribution. Am J Phys Anthropol. 1987 ;72(4):437-9.
  • 14. Szulc P, Bartkowiak P, Boch-Kmieciak J, Lewandowski J, Owczarkowska E. The eurofit sit and reach suppleness test competence of ballet school students. Trends in sport sciences. 2013; 2(20); 101-106.
  • 15. Cuberek R, Machová I, Lipenská M. Reliability of V sit-and-reach test used for flexibility self-assessment in females. Acta Gymnica. 2013;43(1):35-39.
  • 16. Mathiowetz V, Weber K, Volland G, Kashman N. Reliability and validity of grip and pinch strength evaluations. The Journal of hand surgery. 1984;9(2):222-226.
  • 17. Stark T, Walker B, Phillips JK, Fejer R, Beck R. Hand-held dynamometry correlation with the gold standard isokinetic dynamometry: a systematic review. PM&R. 2011;3(5):472-479.
  • 18. Andrews AW, Thomas MW, Bohannon RW. Normative values for isometric muscle force measurements obtained with hand-held dynamometers. Physical therapy. 1996;76(3):248-259.
  • 19. Bohannon RW. Reference values for extremity muscle strength obtained by hand-held dynamometry from adults aged 20 to 79 years. Archives of physical medicine and rehabilitation. 1997;78(1):26-32.
  • 20. Kannus P. Isokinetic evaluation of muscular performance. International journal of sports medicine. 1994;15(S 1):S11-S18.
  • 21. Sahin N, Baskent A, Ugurlu H, Berker E. Isokinetic evaluation of knee extensor/flexor muscle strength in patients with hypermobility syndrome. Rheumatology international. 2008;28:643-648.
  • 22. Hayashi K, Miyachi M, Seno N, et al. Variations in carotid arterial compliance during the menstrual cycle in young women. Experimental physiology. 2006;91(2):465-472.
  • 23. Yamamoto K, Kawano H, Gando Y, et al. Poor trunk flexibility is associated with arterial stiffening. American Journal of Physiology-Heart and Circulatory Physiology. 2009;
  • 24. Yazici M, Ataoglu S, Makarc S, et al. The relationship between echocardiographic features of mitral valve and elastic proporties of aortic wall and Beighton hypermobility score in patients with mitral valve prolapse. Japanese Heart Journal. 2004;45(3):447-460.
  • 25. Handler CE, Child A, Light N, Dorrance DE. Mitral valve prolapse, aortic compliance, and skin collagen in joint hypermobility syndrome. Heart. 1985;54(5):501-508.
  • 26. Petersen JW, Douglas JY. Tenascin-X, collagen, and Ehlers–Danlos syndrome: Tenascin-X gene defects can protect against adverse cardiovascular events. Medical hypotheses. 2013;81(3):443-447.
  • 27. Binder J, Bailey KR, Seward JB, et al. Aortic augmentation index is inversely associated with cardiorespiratory fitness in men without known coronary heart disease. American journal of hypertension. 2006;19(10):1019-1024.
  • 28. Boreham CA, Ferreira I, Twisk JW, Gallagher AM, Savage MJ, Murray LJ. Cardiorespiratory fitness, physical activity, and arterial stiffness: the Northern Ireland Young Hearts Project. Hypertension. 2004;44(5):721-726.
  • 29. Varol BK, ŞIRAYDER U, Sandal M, Tuncer D. The effect of generalized joint hypermobility on functional capacity, pulmonary function, respiratory muscle strength, and chest expansion in healthy young adults. Journal of Health Sciences and Medicine. 6(2):300-306.
  • 30. Hakim A, O'Callaghan C, De Wandele I, Stiles L, Pocinki A, Rowe P. Cardiovascular autonomic dysfunction in Ehlers–Danlos syndrome—hypermobile type. Wiley Online Library; 2017:168-174.
  • 31. Roma M, Marden CL, De Wandele I, Francomano CA, Rowe PC. Postural tachycardia syndrome and other forms of orthostatic intolerance in Ehlers-Danlos syndrome. Autonomic Neuroscience. 2018;215:89-96.
  • 32. Clinch J, Deere K, John T, Clarke E. Epidemiology of generalised joint laxity in 14 year old children from the UK: a population-based evaluation. Pediatric Rheumatology. 2012;10(1):1-1.
  • 33. Engelbert RH, van Bergen M, Henneken T, Helders PJ, Takken T. Exercise tolerance in children and adolescents with musculoskeletal pain in joint hypermobility and joint hypomobility syndrome. Pediatrics. 2006;118(3):e690-e696.
  • 34. Ewertowska P, Trzaskoma Z, Sitarski D, Gromuł B, Haponiuk I, Czaprowski D. Muscle strength, muscle power and body composition in college-aged young women and men with Generalized Joint Hypermobility. Plos one. 2020;15(7):e0236266.
  • 35. Massy-Westropp N, Toubia C. Hypermobility as measured by the Beighton hypermobility test is not predictive of hand grip strength in young adults. Journal of Musculoskeletal Research. 2013;16(01):1350006.
  • 36. Juul-Kristensen B, Hansen H, Simonsen EB, et al. Knee function in 10-year-old children and adults with Generalised Joint Hypermobility. The Knee. 2012;19(6):773-778.
  • 37. Jindal P, Narayan A, Ganesan S, MacDermid JC. Muscle strength differences in healthy young adults with and without generalized joint hypermobility: a cross-sectional study. BMC sports science, medicine and rehabilitation. 2016;8(1):1-9.
  • 38. Scheper M, Engelbert R, Rameckers E, Verbunt J, Remvig L, Juul-Kristensen B. Children with generalised joint hypermobility and musculoskeletal complaints: state of the art on diagnostics, clinical characteristics, and treatment. BioMed research international. 2013;2013
  • 39. Massy-Westropp C, Massy-Westropp N, Wechalekar H. Normative Values for Pinch Strength—Relationship With Joint Hypermobility as Measured With the Beighton Criteria. Journal of Hand Surgery Global Online. 2023;5(3):272-276.
  • 40. Jensen BR, Olesen AT, Pedersen MT, et al. Effect of generalized joint hypermobility on knee function and muscle activation in children and adults. Muscle & nerve. 2013;48(5):762-769.
There are 40 citations in total.

Details

Primary Language English
Subjects Physical Medicine and Rehabilitation
Journal Section ORİJİNAL MAKALE
Authors

Hande Özdemir 0000-0002-1717-9604

Filiz Tuna 0000-0002-9563-8028

Derya Demirbağ Kabayel 0000-0003-1974-8054

Publication Date May 27, 2024
Submission Date April 2, 2024
Acceptance Date May 15, 2024
Published in Issue Year 2024 Volume: 46 Issue: 3

Cite

Vancouver Özdemir H, Tuna F, Demirbağ Kabayel D. The Health-Related Physical Fitness of University Female Students with and without Generalized Joint Hypermobility: A Case-Control Study. Osmangazi Tıp Dergisi. 2024;46(3):463-74.


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