The Importance of Cardiac Markers in Diagnosis of Acute Myocardial Infarction

Abstract

Each year, approximately 10% of millions of patients who appealed to emergency services with heart attack complaints are diagnosed with heart attacks. The fact that the patient potential is so high causes a serious concentration in the hospitals. Cardiac markers are important for giving specific and rapid results in the identification of acute myocardial infarction (AMI) and non-cardiac cases. In this study; it was aimed importance of cardiac markers in early diagnosis of AMI and investigation of lipid profile effects on AMI. In the study, Serum troponin (TnT), creatine kinase (CK), CK-MB, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), triglyceride, total cholesterol (TC), LDL- , and HDL-cholesterol (HDL-c) levels were analyzed by routine biochemical methods in 33 healthy individuals (9 females, 24 males)  and 27 patients (8 females, 19 males) who treated with the diagnosis of AMI in Coronary Intensive Care Unit at Dermlupınar University Evliya Çelebi Training and Research Hospital. In the statistical analysis, the ALT, AST, CK, CK-MB, LDH and TnT parameters of the patient group were found to be very high when compared to controls (p <0.0001). The significances determined statistically in triglyceride, LDL-cholesterol, total cholesterol and HDL-cholesterol levels were (p <0.001), (p <0.05), (p <0.05), (p> 0.1), respectively. It was thought that cardiac marker analysis is a highly specific marker for AMI diagnosis and that it is greatly facilitated in the elimination of non-cardiac cases.

Keywords

• cardiac markers,non-cardiac cases,acute myocardial infarction

Akut Miyokard İnfarktüsü Tanısında Kardiyak Markörlerin Önemi

Abstract

Her yıl, kalp krizi şikâyetleriyle acil servislere başvuran milyonlarca hastadan yaklaşık %10’una kalp krizi tanısı konulmaktadır. Hasta potansiyelinin bu denli yüksek olması, hastanelerde ciddi bir yoğunluğa neden olmaktadır. Kardiyak markörler, akut miyokard infarktüsünün (AMİ) tanısında ve non-kardiyak vakalarda spesifik ve hızlı sonuçlar vermesi açısından önemlidir. Bu çalışmada; kardiyak markörlerin AMİ erken tanısındaki önemi ve lipid profilinin AMİ üzerine etkisinin araştırılması amaçlanmıştır. Dumlupınar Üniversitesi Evliya Çelebi Eğitim Araştırma Hastanesi Koroner Yoğun Bakım Ünitesi’nde AMİ teşhisiyle tedavi edilen 27 hasta (8 kadın, 19 erkek) ve 33 sağlık sağlıklı bireylerde (9 kadın, 24 erkek) serum troponin (TnT), kreatin kinaz (CK), CK-MB, alanin aminotransferaz (ALT) , aspartat aminotransferaz (AST), laktat dehidrogenaz (LDH), trigliserid, total kolesterol (TC), LDL-kolesterol (LDL-c), ve HDL-kolesterol (HDL-c) düzeyleri  rutin biyokimyasal metotlarla analiz edildi. İstatistiki analizlerde, hasta grubunun ALT, AST, CK, CK-MB, LDH ve TnT parametreleri kontrol ile karşılaştırıldığında çok yüksek bulunmuştur (p < 0.0001). Trigliserit, LDL-kolesterol, Total Kolesterol ve HDL-kolesterol düzeylerinde istatistiksel olarak tespit edilen anlamlılıklar sırasıyla (p < 0.001), (p < 0.05), (p < 0.05), (p > 0.1) şeklindedir. Kardiyak markör analizinin AMİ teşhisi için oldukça spesifik bir belirleyici olduğu, non-kardiyak vakaların elimine edilmesinde büyük kolaylık sağladığı düşünülmektedir. 

Keywords

• Kalp krizi,kardiyak markörler,akut miyokard infarktüsü,non-kardiyak vaka

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