Investigation of the Effect of Progesterone Level on In-Vitro Fertilization Success The Day Before Frozen-Thawed Embryo Transfer

Abstract

Objective: To observe the effects of serum progesterone concentrations measured on the day before transfer on pregnancy, miscarriage and live birth rates in frozen-thawed embryo transfer (DCE) cycles. Materials and Methods: In this retrospective study, the results of 67 ICET cycles performed in a single center between 01.01.2019 and 01.09.2019 were analyzed. Pregnancy, abortion and live birth outcomes were compared in DCE cycles below and above the threshold value of 10.64 ng/ml of progesterone. Results: According to progesterone concentrations, the age, causes of infertility, stimulation days, body mass index (BMI) values, endometrial thicknesse, and mean number of embryos transferred were similar in the groups. When pregnancy rates were compared in terms of progesterone concentrations, pregnancy rates were significantly higher in the progesterone>10.65 ng/ml group p=0.023. We found that 50% (21) of total pregnancies resulted in a live birth, and 90.5% (19) of pregnancies resulting in live birth consisted of pregnant women whose progesterone levels were progesterone>10.64 ng/ml. Those whose progesterone levels were <10.64 ng/ml constituted 28.6% (12) of positive pregnant women, 83.3% (10) of these pregnancies were found to be with miscarriage, and 16.7% (2) of them resulted with live births. Conclusion: It is observed that pregnancy outcomes are higher in cycles where progesterone levels are progesterone>10.64 ng/ml, and most of the pregnancies that occur result in a live birth.

Keywords

• Embryo transfer
• hormone replacement therapy
• pregnancy outcomes

Dondurulmuş Çözülmüş Embriyo Transferi Öncesi Günü Progesteron Seviyesinin İn-Vitro Fertilizasyon Başarısına Etkisinin İncelenmesi

Öz

Amaç: Dondurulmuş çözülmüş embriyo transfer (DÇET) sikluslarında transfer öncesi gün ölçülen serum progesteron konsantrasyonlarının gebelik, düşük ve canlı doğum oranları üzerine etkilerini gözlemlemek. Materyal ve Metot: Bu retrospektif çalışmada, tek bir merkezde 01.01.2019 ile 01.09.2019 tarihleri arasında gerçekleştirilen 67 DÇET siklus sonuçları incelendi. Progesteron düzeyleri 10,64 ng/ml eşik değerinin altındaki ve üstündeki DÇET sikluslarındaki gebelik, düşük ve canlı doğum sonuçları karşılaştırıldı. Bulgular: Progesteron konsantrasyonlarına göre DÇET gruplarındaki hastaların yaşı, infertilite nedenleri, sitimülasyon gün sayıları, beden kitle indeks (BKİ) değerleri, endometriyum kalınlıkları ve transfer edilen ortalama embriyo sayıları benzerdi. Gebelik oranları karşılaştırıldığında progesteronun>10,65 ng/ml grubunda gebelik oranları anlamlı derecede yüksekti (p=0,023). Toplam gebeliklerin %50 (21)’sinin canlı doğum ile sonuçlandığı, canlı doğumla sonuçlanan gebeliklerin %90,5 (19)’nin progesteron düzeylerinin >10,64 ng/ml olan gebelerden oluştuğu bulundu. Progesteron düzeyleri <10,64 ng/ml olanların pozitif gebelerin %28,6 (12)’sını oluşturduğu, bu gebeliklerin %83,3 (10)’ünün düşük ile, %16,7 (2)’sinin de canlı doğum ile sonuçlandığı bulundu. Sonuç: Progesteron düzeylerinin >10,64 ng/ml olduğu sikluslarda gebelik sonuçlarının daha yüksek olduğu ve oluşan gebeliklerin büyük çoğunluğunun canlı doğumla sonuçlandığı görülmektedir.

Anahtar Kelimeler

• Embriyo transferi
• gebelik sonuçları
• hormon replasman tedavisi

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