The Relationship Between Insulin Resistance and Trace Elements in Patients With Polycystic Ovary Syndrome

Year 2020, Volume: 5 Issue: 2, 375 - 382, 30.06.2020

Ragip Balahoroglu , Ali Kemal Zirek , Erdem Çokluk , Murat Atmaca , Mehmet Şekeroğlu , Zübeyir Huyut

https://doi.org/10.26453/otjhs.571510

Cited By: 3

Abstract

Objective: The study was investigate serum zinc (Zn), chromium (Cr), cobalt (Co) and manganese (Mn) concentrations in relation to hormone levels and polycystic ovary syndrome (PCOS).

Materials and Methods: Fourty women between 18-40 years of age diagnosed with PCOS. We also seleceted 40 healty volunteers as the control group. Serum Zn, Cr, Mn, follicular stimulating hormone (FSH), luteinizing hormone(LH), Dehydroepiandrosterone sulfate (DHEA-S), total testosterone (TT), sex hormone binding globulin (SHBG), insulin, glucose, cholesterol, triglyceride, High Density Lipoprotein (HDL-C) and Low density lipoprotein (LDL-C) concentrations were determined. 

Results: Insulin, glucose, triglyceride, DHEA-S levels were significantly higher in the PCOS group than in the control group, while FSH and Mn levels were significantly lower in the HOMA-IR group than in the control group (p< 0.05). 

Conclusions: A possible association is perceptible in our study between some of serum trace elements and women with PCOS. The association attains a connotative level with the involvement of IR in it. Additional studies evaluating the effects of these elements supplementation would be required to confirm the hypothesis as well as to ascertain whether insulin resistance in the presence of manganese deficiency can directly lead to oxidative stress. 

Keywords

Chromium, cobalt, insulin resistance, manganese, polycystic ovary syndrome

Supporting Institution

Yuzuncu Yil University BAPB

Project Number

2013-SBE-YL052

Thanks

Special thanks to Yuzuncu Yil University BAPB (2013-SBE-YL052)

Polikistik Over Sendromlu Hastalarda İnsülin Direnci ve Eser Elementlerin İlişkisi

Abstract

Amaç: Bu çalışma, polikistik over sendromunda (PKOS) hormon düzeyleriyle çinko (Zn), krom (Cr), kobalt (Co) ve mangan (Mn) konsantrasyonlarının ilişkisini incelemek için tasarlanmıştır.

Materyal ve Metot: Çalışmaya endokrinoloji polikliniğine başvuran 18-40 yaş arası PKOS teşhisi konulan 40 kadın ve aynı sayıda sağlıklı gönüllü alındı. Serum Zn, Cr, Mn, Foliküler stimüle edici hormon (FSH), Lüteinleştirici Hormon (LH), Dehidroepiandrosteron (DHEA-S), Total Testosteron (TT), Seks hormonu bağlayıcı globulin (SHBG), insülin, glukoz, kolesterol, trigliserit, yüksek yoğunluklu lipoproteinler (HDL) ve düşük yoğunluklu lipoproteinler (LDL) konsantrasyonları analiz edildi.

Bulgular: PKOS grubunda insülin, glukoz, trigliserit, DHEA-S düzeyleri kontrol grubuna göre anlamlı derecede yüksek iken, FSH ve Mn düzeyleri HOMA-IR grubunda kontrol grubuna göre anlamlı derecede düşüktü (p <0.05). 

Sonuç: Çalışmamızda serum eser elementleri ile PKOS arasında bir ilişki saptanırken, IR’nin dahil edilmesiyle ilişki düzeyi artmaktadır. Ayrıca, mangan eksikliği varlığında insülin direncinin doğrudan oksidatif strese yol açıp açamayacağını belirlemek için bu elementin takviyesinin etkilerini değerlendiren ek çalışmalara ihtiyaç olacağını da düşünmekteyiz. 

Keywords

İnsülin direnci, kobalt, krom, manganez, polikistik over sendromu

Project Number

2013-SBE-YL052

References

• 1. Teede HJ, Misso ML, Deeks AA, et al. Assessment and management of polycystic ovary syndrome: summary of an evidence-based guideline. The Medical Journal of Australia. 2011;195(6):S65.
• 2. De Leo V, Musacchio M, Cappelli V, Massaro M, Morgante G, Petraglia F. Genetic, hormonal and metabolic aspects of PCOS: an update. Reproductive Biology and Endocrinology. 2016;14(1):38. doi: 10.1186/s12958-016-0173-x
• 3. Cortón M, Botella-Carretero JI, López JA, et al. Proteomic analysis of human omental adipose tissue in the polycystic ovary syndrome using two-dimensional difference gel electrophoresis and mass spectrometry. Human Reproduction. 2007;23(3):651-661.
• 4. Spritzer PM, Lecke SB, Fabris VC, Ziegelmann PK, Amaral L. Blood Trace Element Concentrations in Polycystic Ovary Syndrome: Systematic Review and Meta-analysis. Biological trace element research. 2017;175(2):254-262.
• 5. Cruz KJC, de Oliveira ARS, do Nascimento Marreiro D. Antioxidant role of zinc in diabetes mellitus. World journal of diabetes. 2015;6(2):333-337.
• 6. Savsatli Y, Ozcan A, Catal M, Seyis F, Akbulut M, Turumtay EA. Trace Elements In Bitter Melon (Momordica Charantia L.) And Their Distribution In Different Plant Parts. 2006.
• 7. Sreejayan N, Dong F, Kandadi MR, Yang X, Ren J. Chromium alleviates glucose intolerance, insulin resistance, and hepatic ER stress in obese mice. Obesity. 2008;16(6):1331-1337.
• 8. Chakraborty P, Ghosh S, Goswami S, Kabir SN, Chakravarty B, Jana K. Altered trace mineral milieu might play an aetiological role in the pathogenesis of polycystic ovary syndrome. Biological trace element research. 2013;152(1):9-15.
• 9. Siddiqui K, Bawazeer N, Scaria Joy S. Variation in macro and trace elements in progression of type 2 diabetes. The Scientific World Journal. 2014;2014:461591.
• 10. Yildirim O, Buyukbingol Z. Effect of cobalt on the oxidative status in heart and aorta of streptozotocin‐induced diabetic rats. Cell biochemistry and function. 2003;21(1):27-33.
• 11. Rotterdam E, Group A-SPCW. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertility and sterility. 2004;81(1):19-25.
• 12. Zheng G, Wang L, Guo Z, et al. Association of serum heavy metals and trace element concentrations with reproductive hormone levels and polycystic ovary syndrome in a Chinese population. Biological trace element research. 2015;167(1):1-10.
• 13. Goullé J-P, Mahieu L, Castermant J, et al. Metal and metalloid multi-elementary ICP-MS validation in whole blood, plasma, urine and hair: Reference values. Forensic Science International. 2005;153(1):39-44.
• 14. Celik C, Bastu E, Abali R, et al. The relationship between copper, homocysteine and early vascular disease in lean women with polycystic ovary syndrome. Gynecological Endocrinology. 2013;29(5):488-491.
• 15. DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertility and sterility. 2005;83(5):1454-1460.
• 16. Cegil y. Research Of Hormon’s And Insulin Levels In Patients With Polycystic Ovary Syndrome. Specialization Thesis, Edirne, Turkey.: Trakya University; 2009.
• 17. Bagis HT, Hacıvelioglu S, Haydardedeoglu B, et al. Prevalance Of Insulın Resıstance, Impaired Glucose Tolerans Test And Diabetes Mellitus In Women With Polcystic Ovary Syndrome; Analysis Of 235 Patients. Journal of Turkish Obstetric and Gynecology Society.2008; 5(2):99-104.
• 18. Turan V, Erdogan M, Yeniel Ö, Ergenoğlu M, Kazandi M. The assessment of biochemical, hormonal blood parameters and clinical symptoms of 89 polycystic ovarian syndrome patients. Ege Journal of Medicine. 2011;50(3):179-182.
• 19. Ovalle F, Azziz R. Insulin resistance, polycystic ovary syndrome, and type 2 diabetes mellitus. Fertility and sterility. 2002;77(6):1095-1105.
• 20. Basaki M, Saeb M, Nazifi S, Shamsaei H. Zinc, copper, iron, and chromium concentrations in young patients with type 2 diabetes mellitus. Biological Trace Element Research. 2012;148(2):161-164.
• 21. Karagun BS, Temiz F, Ozer G, et al. Chromium levels in healthy and newly diagnosed type 1 diabetic children. Pediatrics International. 2012;54(6):780-785.
• 22. Stefanidou M, Maravelias C, Dona A, Spiliopoulou C. Zinc: a multipurpose trace element. Archives of toxicology. 2006;80(1):1-9.
• 23. Kurdoglu Z, Kurdoglu M, Demir H, Sahin H. Serum trace elements and heavy metals in polycystic ovary syndrome. Human & experimental toxicology. 2012;31(5):452-456.
• 24. Vashum KP, McEvoy M, Milton AH, Islam MR, Hancock S, Attia J. Is serum zinc associated with pancreatic beta cell function and insulin sensitivity in pre-diabetic and normal individuals? Findings from the Hunter Community Study. PLoS One. 2014;9(1):e83944. doi:10.1371/journal.pone.0083944
• 25. García OP, Ronquillo D, del Carmen Caamaño M, et al. Zinc, iron and vitamins A, C and E are associated with obesity, inflammation, lipid profile and insulin resistance in Mexican school-aged children. Nutrients. 2013;5(12):5012-5030.
• 26. Chakraborty P, Goswami S, Rajani S, et al. Recurrent pregnancy loss in polycystic ovary syndrome: role of hyperhomocysteinemia and insulin resistance. PLoS One. 2013;8(5):e64446.
• 27. Ozden O, Park SH, Kim HS, et al. Acetylation of MnSOD directs enzymatic activity responding to cellular nutrient status or oxidative stress. Aging (Albany NY). 2011;3(2):102-117.
• 28. Saker F, Ybarra J, Leahy P, Hanson RW, Kalhan SC, Ismail-Beigi F. Glycemia-lowering effect of cobalt chloride in the diabetic rat: role of decreased gluconeogenesis. American Journal of Physiology-Endocrinology and Metabolism. 1998;274(6):984-991.
• 29. Jomova K, Valko M. Advances in metal-induced oxidative stress and human disease. Toxicology. 2011;283(2-3):65-87.