pam med j Pamukkale Medical Journal 1308-0865 Pamukkale University 10.31362/patd.1707522 ​Internal Diseases İç Hastalıkları Prediction of pathological complete response after neoadjuvant treatment in triple negative breast cancer: a single center experience Üçlü negatif meme kanserinde neoadjuvan tedavi sonrası patolojik tam yanıtın öngörülmesi: tek merkez deneyimi https://orcid.org/0000-0002-0930-1016 Ulukal Karancı Ece SBÜ ANTALYA EĞİTİM VE ARAŞTIRMA HASTANESİ https://orcid.org/0000-0001-8310-1752 Güzel Halil Göksel SBÜ ANTALYA EĞİTİM VE ARAŞTIRMA HASTANESİ https://orcid.org/0000-0003-0290-8787 Öztürk Banu SBÜ ANTALYA EĞİTİM VE ARAŞTIRMA HASTANESİ 04 13 2026 19 2 237 242 05 30 2025 08 22 2025 Copyright © 2008, Pamukkale Medical Journal 2008 Pamukkale Medical Journal

Purpose: To identify clinicopathological factors associated with pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in patients with triple-negative breast cancer (TNBC).Matherials and methods: A retrospective study of 51 women with stage I–III TNBC who received NAC between January 2019 and December 2024 at Antalya Training and Research Hospital. Binary logistic regression was used to determine independent predictors of pCR.Results: The median age was 49 years (range: 28-79), and 28 patients (54.9%) achieved pCR. Patients aged ≥60 were significantly less likely to achieve pCR (OR: 0.22; 95% CI: 0.05-0.98; p=0.048*). No significant associations were found for carboplatin or pembrolizumab use.Conclusion: This real-world cohort confirms that pCR rates are consistent with literature. Advanced age was a significant negative predictor, emphasizing the importance of personalized approaches in elderly patients.

Amaç: Üçlü negatif meme kanseri (TNBC) hastalarında neoadjuvan kemoterapi (NAK) sonrası patolojik tam yanıt (pTY) ile ilişkili klinikopatolojik faktörleri belirlemektir.Gereç ve yöntem: Ocak 2019 - Aralık 2024 tarihleri arasında Antalya Eğitim ve Araştırma Hastanesi'nde NAK almış evre I–III TNBC tanılı 51 kadın hastanın verileri retrospektif olarak incelendi. pTY'yi öngören bağımsız değişkenleri belirlemek amacıyla ikili lojistik regresyon analizi yapıldı.Bulgular: Ortanca yaş 49 (28-79) idi ve 28 hastada (%54,9) pTY elde edildi. Yaş ≥60 olan hastalarda pTY elde etme olasılığı anlamlı şekilde düşüktü (OR: 0,22; %95 GA: 0,05-0,98; p=0,048*). Karboplatin ve pembrolizumab kullanımı ile pTY arasında istatistiksel olarak anlamlı ilişki bulunmadı.Sonuç: Gerçek yaşam verilerine dayanan bu çalışmada, pTY oranı literatürle uyumluydu. Yaşlı hastalarda pTY oranının düşük olması, kişiselleştirilmiş tedavi yaklaşımlarının gerekliliğini vurgulamaktadır.

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