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Evaluation Of Hearing Functions of Children with Type 1 Diabetes: A 2-Year Retrospective Study

Year 2024, Volume: 6 Issue: 1, 11 - 15, 01.03.2024
https://doi.org/10.38175/phnx.1378911

Abstract

Objective: Our study aims to investigate the differences in pure tone audiometry and tympanograms in terms of gender, disease duration, and right-left ear in children with Type 1 diabetes mellitus (Type 1 DM).
Material and Method: For our study, a total of 109 patients between the ages of 0-18 who were diagnosed with Type 1 DM between 2016-2017 were identified. Among these, 26 children, 52 ears, aged between 2-18, who applied to the Ear Nose Throat outpatient clinic for different reasons and had anamnesis and examination information, were included. Then, hearing thresholds and middle ear functions were evaluated by looking at pure-tone audiometers and tympanograms. Whether the patients met the study criteria was retrospectively determined by using the patient registration forms filled out by the pediatric endocrinology.
Results: In the measurements made for the right and left ears, the conduction threshold values at a frequency of 4000 and 8000 Hz were found to be statistically significantly higher values in the Type 1 DM patient group for 5 years and longer than the control group with Type 1 DM for less than 5 years (p<0.05). Both right and left ear bone canal threshold values of the patient group with diabetes for 5 years or longer were found to be statistically significantly higher at a frequency of 4000 Hz (p<0.05). A statistically significant and negative moderate correlation was found between the threshold values of speech discrimination (SD) in the right and left ears and the duration of the disease.
Conclusion: As a result of our study, individuals with Type 1 DM were found to have a higher risk of developing hearing loss. For this reason, it is recommended to examine hearing in detail and to establish a clinical examination protocol in this patient group.

References

  • Dąbrowski M, Mielnik-Niedzielska G, Nowakowski A. Involvement of the auditory organ in type 1 diabetes mellitus. Endokrynologia Polska. 2011;62(2):138-44.
  • Fowler MJ. Microvascular and macrovascular complications of diabetes. Clinical diabetes. 2008;26(2):77-82.
  • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2010;33:S62-S9.
  • Türkiye Endokrinoloji ve Metabolizma Derneği, Diabetes Mellitus ve Komplikasyonlarının Tanı, Tedavi ve İzlem Kılavuzu 6. Baskı, Miki Matbaacılık San ve Tic Ltd Şti Ankara. 2013:16-7.
  • Maia CAS, de Campos CAH. Diabetes mellitus as etiological factor of hearing loss. Brazilian journal of otorhinolaryngology. 2005;71(2):208-14.
  • Mellitus D. Diagnosis and classification of diabetes mellitus. Diabetes care. 2005;28(S37):S5-S10.
  • Bakanlığı Sağlık, Kurumu HS. Türkiye Diyabet Programı 2015-2020. Türkiye Halk Sağlığı Kurumu, Yayın. 2014(816):13.
  • American Diabetes Association. Standards of medical care in diabetes--2014. Diabetes care. 2014;37:S14.
  • Teng ZP, Tian R, Xing FL, Tang H, Xu JJ, Zhang BW, et al. An association of type 1 diabetes mellitus with auditory dysfunction: A systematic review and meta‐analysis. The Laryngoscope. 2017;127(7):1689-97.
  • Xipeng L, Ruiyu L, Meng L, Yanzhuo Z, Kaosan G, Liping W. Effects of diabetes on hearing and cochlear structures. Journal of Otology. 2013;8(2):82-7.
  • Malucelli DA, Malucelli FJ, Fonseca VR, Zeigeboim B, Ribas A, de Trotta F, et al. Hearing loss prevalence in patients with diabetes mellitus type 1. Brazilian journal of otorhinolaryngology. 2012;78(3):105-15.
  • Diniz TH, Guida HL. Hearing loss in patients with diabetes mellitus. Brazilian journal of otorhinolaryngology. 2009;75(4):573-8.
  • Klagenberg KF, Zeigelboim BS, Jurkiewicz AL, Martins-Bassetto J. Vestibulocochlear manifestations in patients with type I diabetes mellitus. Brazilian journal of otorhinolaryngology. 2007;73(3):353-8.
  • Belgin E. Periferik iĢitme sisteminin anatomi ve fizyolojisi (Bölüm 3). TemelOdyoloji,(Belgin E, ed), Ankara, Güneş Tıp Kitabevi. 2015;30.
  • Di Nardo W, Ghirlanda G, Paludetti G, Cercone S, Saponara C, Del Ninno M, et al. Distortion-product otoacoustic emissions and selective sensorineural loss in IDDM. Diabetes care. 1998;21(8):1317-21.
  • Golemanov V, Todorova S. High-frequency tonal threshold hearing changes in diabetes mellitus. Vutreshni Bolesti. 1983;22(4):59-62.
  • Okhovat SA, Moaddab MH, Okhovat SH, Al-Azab AAA, Saleh FAA, Oshaghi S, et al. Evaluation of hearing loss in juvenile insulin dependent patients with diabetes mellitus. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences. 2011;16(2):179.
  • Cullen J, Cinnamond MJ. Hearing loss in diabetics. The Journal of Laryngology & Otology. 1993;107(3):179-82.
  • Elamin A, Fadlallah M, Tuevmo T. Hearing loss in children with type 1 diabetes. Indian Pediatr. 2005;42(1):15-21.
  • Pessin ABB, Martins RHG, de Paula Pimenta W, Simões ACP, Marsiglia A, Amaral AV. Auditory evaluation in patients with type 1 diabetes. Annals of Otology, Rhinology & Laryngology. 2008;117(5):366-70.
  • Wackym PA, Linthicum Jr FH. Diabetes mellitus and hearing loss: clinical and histopathologic relationships. The American journal of otology. 1986;7(3):176-82.
  • Bakır S. KBB notları. Ankara: Derman Tıbbi Yayıncılık. 2015.
  • Kocyigit M, Bezgin SU, Cakabay T, Ortekin SG, Yıldız M, Ozkaya G, et al. An Investigation of Hearing (250-20,000 Hz) in Children with Endocrine Diseases and Evaluation of Tinnitus and Vertigo Symptoms. International archives of otorhinolaryngology. 2020;24(2):204-11.
  • Guillausseau P-J, Massin P, Dubois-LaForgue D, Timsit J, Virally M, Gin H, et al. Maternally inherited diabetes and deafness: a multicenter study. Annals of internal medicine. 2001;134:721-8.
  • Smith TL, Raynor E, Prazma J, Buenting JE, Pillsbury HC. Insulin‐dependent diabetic microangiopathy in the inner ear. The Laryngoscope. 1995;105(3):236-40.
  • Treviño-González JL, Campuzano-Bustamante D, Flores-Caloca O, Santos-Lartigue R, Villegas-González Jr M. Prevalence of sensorineural hearing loss in children and adolescents with diabetes mellitus. Medicina universitaria. 2015;17(68):133-7.
  • Silva BCS, Mantello EB, Freitas MCF, Foss MC, de Lima Isaac M, Anastasio ART. Speech perception performance of subjects with type I diabetes mellitus in noise. Brazilian journal of otorhinolaryngology. 2017;83(5):574-9.

Tip 1 Diyabetli Çocukların İşitme Fonksiyonlarının Değerlendirilmesi: 2 Yıllık Retrospektif Çalışma

Year 2024, Volume: 6 Issue: 1, 11 - 15, 01.03.2024
https://doi.org/10.38175/phnx.1378911

Abstract

Amaç: Çalışmamızın amacı; Tip 1 diabetus mellitus (Tip 1 DM) çocuklarda, saf ses odyometrileri ve timpanogramlarının; cinsiyet, hastalık süresi ve sağ-sol kulak yönünden farklılıklarının araştırılmasıdır.
Gereç ve Yöntem: Çalışmamız için 2016-2017 yıllarında Tip 1 DM tanısı alan yaşları 0-18 arasında değişen toplam 109 hasta belirlenmiştir. Bunların içerisinden, kulak burun boğaz (KBB) polikliniğine farklı sebeplerden başvuran, anamnez ve muayene bilgileri olan yaşları 2-18 arasında değişen, 26 çocuk 52 kulak dâhil edilmiştir. Ardından saf ses odyometrileri ve timpanogramlarına bakılarak işitme eşikleri ve orta kulak fonksiyonları değerlendirilmiştir. Hastaların çalışma kriterlerine uygun olup olmadığı ise pediatrik endokrinoloji tarafından doldurulan hasta kayıt formlarından geriye dönülerek belirlenmiştir.
Bulgular: Sağ ve sol kulak için yapılan ölçümlerde 4000 ve 8000 Hz frekansta hava yolu eşik değerlerinin 5 yıl ve daha uzun süre Tip 1 DM’li hasta grubunda, 5 yıldan daha az süre Tip 1 DM’li kontrol grubuna oranla istatistiksel olarak anlamlı bir şekilde daha yüksek değerlerde olduğu bulundu (p<0,05). 5 yıl ve daha uzun süre diyabetli olan hasta grubunun hem sağ, hem de sol kulak kemik yolu eşik değerlerinin 4000 Hz frekansta istatistiksel olarak anlamlı bir şekilde daha yüksek değerlerde bulundu (p<0,05). Sağ ve sol kulak konuşmayı ayırt etme eşik (SD) değerleri ile hastalık süresi değerleri arasında ise istatistiksel olarak anlamlı ve negatif yönlü orta düzeyde ilişki saptandı.
Sonuç: Çalışmamızın sonucunda; Tip 1 DM tanısı olan bireylerde işitme kaybı gelişme riskinin daha fazla olduğu bulunmuştur. Bu sebeple, bu hasta grubunda işitmenin ayrıntılı olarak incelenmesi ve klinik muayene protokolü oluşturulması tavsiye edilmektedir.

References

  • Dąbrowski M, Mielnik-Niedzielska G, Nowakowski A. Involvement of the auditory organ in type 1 diabetes mellitus. Endokrynologia Polska. 2011;62(2):138-44.
  • Fowler MJ. Microvascular and macrovascular complications of diabetes. Clinical diabetes. 2008;26(2):77-82.
  • American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes care. 2010;33:S62-S9.
  • Türkiye Endokrinoloji ve Metabolizma Derneği, Diabetes Mellitus ve Komplikasyonlarının Tanı, Tedavi ve İzlem Kılavuzu 6. Baskı, Miki Matbaacılık San ve Tic Ltd Şti Ankara. 2013:16-7.
  • Maia CAS, de Campos CAH. Diabetes mellitus as etiological factor of hearing loss. Brazilian journal of otorhinolaryngology. 2005;71(2):208-14.
  • Mellitus D. Diagnosis and classification of diabetes mellitus. Diabetes care. 2005;28(S37):S5-S10.
  • Bakanlığı Sağlık, Kurumu HS. Türkiye Diyabet Programı 2015-2020. Türkiye Halk Sağlığı Kurumu, Yayın. 2014(816):13.
  • American Diabetes Association. Standards of medical care in diabetes--2014. Diabetes care. 2014;37:S14.
  • Teng ZP, Tian R, Xing FL, Tang H, Xu JJ, Zhang BW, et al. An association of type 1 diabetes mellitus with auditory dysfunction: A systematic review and meta‐analysis. The Laryngoscope. 2017;127(7):1689-97.
  • Xipeng L, Ruiyu L, Meng L, Yanzhuo Z, Kaosan G, Liping W. Effects of diabetes on hearing and cochlear structures. Journal of Otology. 2013;8(2):82-7.
  • Malucelli DA, Malucelli FJ, Fonseca VR, Zeigeboim B, Ribas A, de Trotta F, et al. Hearing loss prevalence in patients with diabetes mellitus type 1. Brazilian journal of otorhinolaryngology. 2012;78(3):105-15.
  • Diniz TH, Guida HL. Hearing loss in patients with diabetes mellitus. Brazilian journal of otorhinolaryngology. 2009;75(4):573-8.
  • Klagenberg KF, Zeigelboim BS, Jurkiewicz AL, Martins-Bassetto J. Vestibulocochlear manifestations in patients with type I diabetes mellitus. Brazilian journal of otorhinolaryngology. 2007;73(3):353-8.
  • Belgin E. Periferik iĢitme sisteminin anatomi ve fizyolojisi (Bölüm 3). TemelOdyoloji,(Belgin E, ed), Ankara, Güneş Tıp Kitabevi. 2015;30.
  • Di Nardo W, Ghirlanda G, Paludetti G, Cercone S, Saponara C, Del Ninno M, et al. Distortion-product otoacoustic emissions and selective sensorineural loss in IDDM. Diabetes care. 1998;21(8):1317-21.
  • Golemanov V, Todorova S. High-frequency tonal threshold hearing changes in diabetes mellitus. Vutreshni Bolesti. 1983;22(4):59-62.
  • Okhovat SA, Moaddab MH, Okhovat SH, Al-Azab AAA, Saleh FAA, Oshaghi S, et al. Evaluation of hearing loss in juvenile insulin dependent patients with diabetes mellitus. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences. 2011;16(2):179.
  • Cullen J, Cinnamond MJ. Hearing loss in diabetics. The Journal of Laryngology & Otology. 1993;107(3):179-82.
  • Elamin A, Fadlallah M, Tuevmo T. Hearing loss in children with type 1 diabetes. Indian Pediatr. 2005;42(1):15-21.
  • Pessin ABB, Martins RHG, de Paula Pimenta W, Simões ACP, Marsiglia A, Amaral AV. Auditory evaluation in patients with type 1 diabetes. Annals of Otology, Rhinology & Laryngology. 2008;117(5):366-70.
  • Wackym PA, Linthicum Jr FH. Diabetes mellitus and hearing loss: clinical and histopathologic relationships. The American journal of otology. 1986;7(3):176-82.
  • Bakır S. KBB notları. Ankara: Derman Tıbbi Yayıncılık. 2015.
  • Kocyigit M, Bezgin SU, Cakabay T, Ortekin SG, Yıldız M, Ozkaya G, et al. An Investigation of Hearing (250-20,000 Hz) in Children with Endocrine Diseases and Evaluation of Tinnitus and Vertigo Symptoms. International archives of otorhinolaryngology. 2020;24(2):204-11.
  • Guillausseau P-J, Massin P, Dubois-LaForgue D, Timsit J, Virally M, Gin H, et al. Maternally inherited diabetes and deafness: a multicenter study. Annals of internal medicine. 2001;134:721-8.
  • Smith TL, Raynor E, Prazma J, Buenting JE, Pillsbury HC. Insulin‐dependent diabetic microangiopathy in the inner ear. The Laryngoscope. 1995;105(3):236-40.
  • Treviño-González JL, Campuzano-Bustamante D, Flores-Caloca O, Santos-Lartigue R, Villegas-González Jr M. Prevalence of sensorineural hearing loss in children and adolescents with diabetes mellitus. Medicina universitaria. 2015;17(68):133-7.
  • Silva BCS, Mantello EB, Freitas MCF, Foss MC, de Lima Isaac M, Anastasio ART. Speech perception performance of subjects with type I diabetes mellitus in noise. Brazilian journal of otorhinolaryngology. 2017;83(5):574-9.
There are 27 citations in total.

Details

Primary Language English
Subjects Audiology
Journal Section Research Articles
Authors

Emine Tuğba Yorulmaz 0000-0003-1291-1998

Fatmanur Uysal 0000-0002-5019-9818

Seyra Erbek 0000-0002-8453-6069

Early Pub Date December 26, 2023
Publication Date March 1, 2024
Submission Date October 20, 2023
Acceptance Date December 21, 2023
Published in Issue Year 2024 Volume: 6 Issue: 1

Cite

Vancouver Yorulmaz ET, Uysal F, Erbek S. Evaluation Of Hearing Functions of Children with Type 1 Diabetes: A 2-Year Retrospective Study. Phnx Med J. 2024;6(1):11-5.

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