Purpose- This paper presents a novelbusiness model frame that is meant to explicitly include several approaches ofthe Theory of Inventive Problem Solving, disruptive strategies, businessmetrics, problem statement and opportunity formulation, as well as improvementson the profit formula. Methodology-The analysis first addresses the business model canvas, sketching andframing key points behind the development of startups. The analysis on existingbusiness models covers the firm’s value proposition, partners, resources,activities, customer relationships, distribution channels, customers, revenuestreams and cost structure. When it comes to innovative startups, the authoremphasizes that existing template do not explicitly include innovationmeasures, no problem/opportunity formulation, intellectual property, or evenbasic business model concepts as the profit formula. Hence, an innovative frameis developed primarily using the Theory of Inventive Problem Solving techniqueapplied to business and management such as multi-screen analysis ofvalue-conflict mapping, trends of ideality of business system evolutionpositioning, among others; but also, intellectual property, disruptivestrategies, and open innovation, as well as startup metrics. Findings- A novelframe is proposed, providing general guidelines for each of the sections. Anyentrepreneur designing his/her own startup should be able to justify, if notall, most of the items to be able to demonstrate the idea strengths. Regardingthe specific building blocks: “Product Formulation and Inventive ProblemSolving” and “Disruption Strategy”, certain short training should be necessary.Conclusion- The proposedbusiness model frame visually and concisely sketches, besides accuratelystating traditional business concepts, the key innovation concepts that anystartup should integrate to be a game-changer in a competitive market. Thedeveloped frame is a helpful mapping and evaluation tool to accurately describethe business differentiation and innovation attractiveness to potentialinvestors, incubators and accelerators.