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            <front>

                <journal-meta>
                                                                <journal-id>saucis</journal-id>
            <journal-title-group>
                                                                                    <journal-title>Sakarya University Journal of Computer and Information Sciences</journal-title>
            </journal-title-group>
                                        <issn pub-type="epub">2636-8129</issn>
                                                                                            <publisher>
                    <publisher-name>Sakarya University</publisher-name>
                </publisher>
                    </journal-meta>
                <article-meta>
                                        <article-id pub-id-type="doi">10.35377/saucis...1582098</article-id>
                                                                <article-categories>
                                            <subj-group  xml:lang="en">
                                                            <subject>Computer Software</subject>
                                                    </subj-group>
                                            <subj-group  xml:lang="tr">
                                                            <subject>Bilgisayar Yazılımı</subject>
                                                    </subj-group>
                                    </article-categories>
                                                                                                                                                        <title-group>
                                                                                                                                                            <article-title>Diagnosis of Lichen Sclerosus, Morphea, and Vasculitis Using Deep Learning Techniques on Histopathological Skin Images</article-title>
                                                                                                    </title-group>
            
                                                    <contrib-group content-type="authors">
                                                                        <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0009-0004-9715-9006</contrib-id>
                                                                <name>
                                    <surname>Güler</surname>
                                    <given-names>Recep</given-names>
                                </name>
                                                                    <aff>DÜZCE ÜNİVERSİTESİ, MESLEK YÜKSEKOKULU</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0003-3116-1985</contrib-id>
                                                                <name>
                                    <surname>Karapınar Şentürk</surname>
                                    <given-names>Zehra</given-names>
                                </name>
                                                                    <aff>DÜZCE ÜNİVERSİTESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0001-9942-4898</contrib-id>
                                                                <name>
                                    <surname>Gamsızkan</surname>
                                    <given-names>Mehmet</given-names>
                                </name>
                                                                    <aff>DÜZCE ÜNİVERSİTESİ, TIP FAKÜLTESİ</aff>
                                                            </contrib>
                                                    <contrib contrib-type="author">
                                                                    <contrib-id contrib-id-type="orcid">
                                        https://orcid.org/0000-0002-2295-1152</contrib-id>
                                                                <name>
                                    <surname>Özcan</surname>
                                    <given-names>Yunus</given-names>
                                </name>
                                                                    <aff>DÜZCE ÜNİVERSİTESİ, TIP FAKÜLTESİ</aff>
                                                            </contrib>
                                                                                </contrib-group>
                        
                                        <pub-date pub-type="pub" iso-8601-date="20250630">
                    <day>06</day>
                    <month>30</month>
                    <year>2025</year>
                </pub-date>
                                        <volume>8</volume>
                                        <issue>2</issue>
                                        <fpage>312</fpage>
                                        <lpage>321</lpage>
                        
                        <history>
                                    <date date-type="received" iso-8601-date="20241110">
                        <day>11</day>
                        <month>10</month>
                        <year>2024</year>
                    </date>
                                                    <date date-type="accepted" iso-8601-date="20250412">
                        <day>04</day>
                        <month>12</month>
                        <year>2025</year>
                    </date>
                            </history>
                                        <permissions>
                    <copyright-statement>Copyright © 2018, Sakarya University Journal of Computer and Information Sciences</copyright-statement>
                    <copyright-year>2018</copyright-year>
                    <copyright-holder>Sakarya University Journal of Computer and Information Sciences</copyright-holder>
                </permissions>
            
                                                                                                                        <abstract><p>Skin diseases are very common all over the world. The examination can be done by photographing the relevant area or taking a tissue sample to diagnose skin diseases. Examining tissue samples allows examination at the cellular level. This study discussed three skin diseases: lichen sclerosus, morphea, and cutaneous small vessel vasculitis (vasculitis). For this problem, which does not have an open-access dataset in the literature, a dataset consisting of histopathological images belonging to each class was created. Convolutional neural network models were created for this three-class classification problem, and their results were evaluated. In addition, in this problem where it is difficult to obtain sample images, the efficiency of transfer learning methods was evaluated with a limited number of examples. For this purpose, tests were performed with VGG16, ResNet50, InceptionV3, and EfficientNetB4 models, and the results were given. Among all the results, the accuracy value of the VGG16 model was 0.9755 and gave the best result. However, although the accuracy value was quite good, precision, recall, and f1-score metrics values were around 0.65. This shows deficiencies in how often the model correctly predicts the positive class and how well it predicts all positive examples in the dataset.</p></abstract>
                                                            
            
                                                                                        <kwd-group>
                                                    <kwd>Convolutional neural networks</kwd>
                                                    <kwd>  Data augmentation</kwd>
                                                    <kwd>  Transfer learning</kwd>
                                                    <kwd>  Histopathology</kwd>
                                            </kwd-group>
                            
                                                                                                                                                    </article-meta>
    </front>
    <back>
                            <ref-list>
                                    <ref id="ref1">
                        <label>1</label>
                        <mixed-citation publication-type="journal">R. Pangti et al., “A machine learning-based, decision support, mobile phone application for diagnosis of common dermatological diseases,” Journal of the European Academy of Dermatology and Venereology, vol. 35, no. 2, pp. 536–545, Feb. 2021, doi: 10.1111/JDV.16967.</mixed-citation>
                    </ref>
                                    <ref id="ref2">
                        <label>2</label>
                        <mixed-citation publication-type="journal">O. Jimenez-Del-Toro et al., “Analysis of Histopathology Images: From Traditional Machine Learning to Deep Learning,” Biomedical Texture Analysis: Fundamentals, Tools and Challenges, pp. 281–314, Jan. 2017, doi: 10.1016/B978-0-12-812133-7.00010-7.</mixed-citation>
                    </ref>
                                    <ref id="ref3">
                        <label>3</label>
                        <mixed-citation publication-type="journal">G. Litjens et al., “Deep learning as a tool for increased accuracy and efficiency of histopathological diagnosis,” Sci Rep, vol. 6, no. 1, p. 26286, May 2016, doi: 10.1038/srep26286.</mixed-citation>
                    </ref>
                                    <ref id="ref4">
                        <label>4</label>
                        <mixed-citation publication-type="journal">C. Y. Zhu et al., “A Deep Learning Based Framework for Diagnosing Multiple Skin Diseases in a Clinical Environment,” Front Med (Lausanne), vol. 8, p. 626369, Apr. 2021, doi: 10.3389/FMED.2021.626369/BIBTEX.</mixed-citation>
                    </ref>
                                    <ref id="ref5">
                        <label>5</label>
                        <mixed-citation publication-type="journal">M. Tanaka et al., “Classification of a large-scale image database of various skin diseases using deep learning,” Int J Comput Assist Radiol Surg, vol. 16, no. 11, pp. 1875–1887, Nov. 2021, doi: 10.1007/S11548-021-02440-Y/FIGURES/8.</mixed-citation>
                    </ref>
                                    <ref id="ref6">
                        <label>6</label>
                        <mixed-citation publication-type="journal">R. Sadik, A. Majumder, A. A. Biswas, B. Ahammad, and M. M. Rahman, “An in-depth analysis of Convolutional Neural Network architectures with transfer learning for skin disease diagnosis,” Healthcare Analytics, vol. 3, p. 100143, Nov. 2023, doi: 10.1016/J.HEALTH.2023.100143.</mixed-citation>
                    </ref>
                                    <ref id="ref7">
                        <label>7</label>
                        <mixed-citation publication-type="journal">E. Goceri, “Deep learning based classification of facial dermatological disorders,” Comput Biol Med, vol. 128, p. 104118, Jan. 2021, doi: 10.1016/J.COMPBIOMED.2020.104118.</mixed-citation>
                    </ref>
                                    <ref id="ref8">
                        <label>8</label>
                        <mixed-citation publication-type="journal">L. Duran-Lopez, J. P. Dominguez-Morales, A. F. Conde-Martin, S. Vicente-Diaz, and A. Linares-Barranco, “PROMETEO: A CNN-Based Computer-Aided Diagnosis System for WSI Prostate Cancer Detection,” IEEE Access, vol. 8, pp. 128613–128628, 2020, doi: 10.1109/ACCESS.2020.3008868.</mixed-citation>
                    </ref>
                                    <ref id="ref9">
                        <label>9</label>
                        <mixed-citation publication-type="journal">Y. Wu et al., “Recent Advances of Deep Learning for Computational Histopathology: Principles and Applications,” Cancers (Basel), vol. 14, no. 5, p. 1199, Feb. 2022, doi: 10.3390/cancers14051199.</mixed-citation>
                    </ref>
                                    <ref id="ref10">
                        <label>10</label>
                        <mixed-citation publication-type="journal">A. Mumuni and F. Mumuni, “Data augmentation: A comprehensive survey of modern approaches,” Array, vol. 16, p. 100258, Dec. 2022, doi: 10.1016/J.ARRAY.2022.100258.</mixed-citation>
                    </ref>
                                    <ref id="ref11">
                        <label>11</label>
                        <mixed-citation publication-type="journal">F. Perez, C. Vasconcelos, S. Avila, and E. Valle, “Data augmentation for skin lesion analysis,” Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11041 LNCS, pp. 303–311, 2018, doi: 10.1007/978-3-030-01201-4_33/FIGURES/3.</mixed-citation>
                    </ref>
                                    <ref id="ref12">
                        <label>12</label>
                        <mixed-citation publication-type="journal">A. Mikołajczyk and M. Grochowski, “Data augmentation for improving deep learning in image classification problem,” 2018 International Interdisciplinary PhD Workshop, IIPhDW 2018, pp. 117–122, Jun. 2018, doi: 10.1109/IIPHDW.2018.8388338.</mixed-citation>
                    </ref>
                                    <ref id="ref13">
                        <label>13</label>
                        <mixed-citation publication-type="journal">K. Maharana, S. Mondal, and B. Nemade, “A review: Data pre-processing and data augmentation techniques,” Global Transitions Proceedings, vol. 3, no. 1, pp. 91–99, Jun. 2022, doi: 10.1016/J.GLTP.2022.04.020.</mixed-citation>
                    </ref>
                                    <ref id="ref14">
                        <label>14</label>
                        <mixed-citation publication-type="journal">C. Shorten and T. M. Khoshgoftaar, “A survey on Image Data Augmentation for Deep Learning,” J Big Data, vol. 6, no. 1, pp. 1–48, Dec. 2019, doi: 10.1186/S40537-019-0197-0/FIGURES/33.</mixed-citation>
                    </ref>
                                    <ref id="ref15">
                        <label>15</label>
                        <mixed-citation publication-type="journal">M. S. Ali, M. S. Miah, J. Haque, M. M. Rahman, and M. K. Islam, “An enhanced technique of skin cancer classification using deep convolutional neural network with transfer learning models,” Machine Learning with Applications, vol. 5, p. 100036, Sep. 2021, doi: 10.1016/J.MLWA.2021.100036.</mixed-citation>
                    </ref>
                                    <ref id="ref16">
                        <label>16</label>
                        <mixed-citation publication-type="journal">A. Saber, M. Sakr, O. M. Abo-Seida, A. Keshk, and H. Chen, “A Novel Deep-Learning Model for Automatic Detection and Classification of Breast Cancer Using the Transfer-Learning Technique,” IEEE Access, vol. 9, pp. 71194–71209, 2021, doi: 10.1109/ACCESS.2021.3079204.</mixed-citation>
                    </ref>
                                    <ref id="ref17">
                        <label>17</label>
                        <mixed-citation publication-type="journal">M. Fraiwan and E. Faouri, “On the Automatic Detection and Classification of Skin Cancer Using Deep Transfer Learning,” Sensors 2022, Vol. 22, Page 4963, vol. 22, no. 13, p. 4963, Jun. 2022, doi: 10.3390/S22134963.</mixed-citation>
                    </ref>
                                    <ref id="ref18">
                        <label>18</label>
                        <mixed-citation publication-type="journal">H. Aljuaid, N. Alturki, N. Alsubaie, L. Cavallaro, and A. Liotta, “Computer-aided diagnosis for breast cancer classification using deep neural networks and transfer learning,” Comput Methods Programs Biomed, vol. 223, p. 106951, Aug. 2022, doi: 10.1016/J.CMPB.2022.106951.</mixed-citation>
                    </ref>
                                    <ref id="ref19">
                        <label>19</label>
                        <mixed-citation publication-type="journal">S. Hosseinzadeh Kassani, P. Hosseinzadeh Kassani, M. J. Wesolowski, K. A. Schneider, and R. Deters, “Deep transfer learning based model for colorectal cancer histopathology segmentation: A comparative study of deep pre-trained models,” Int J Med Inform, vol. 159, p. 104669, Mar. 2022, doi: 10.1016/J.IJMEDINF.2021.104669.</mixed-citation>
                    </ref>
                                    <ref id="ref20">
                        <label>20</label>
                        <mixed-citation publication-type="journal">N. Ahmad, S. Asghar, and S. A. Gillani, “Transfer learning-assisted multi-resolution breast cancer histopathological images classification,” Visual Computer, vol. 38, no. 8, pp. 2751–2770, Aug. 2022, doi: 10.1007/S00371-021-02153-Y/FIGURES/21.</mixed-citation>
                    </ref>
                                    <ref id="ref21">
                        <label>21</label>
                        <mixed-citation publication-type="journal">A. Ben Hamida et al., “Deep learning for colon cancer histopathological images analysis,” Comput Biol Med, vol. 136, p. 104730, Sep. 2021, doi: 10.1016/J.COMPBIOMED.2021.104730.</mixed-citation>
                    </ref>
                                    <ref id="ref22">
                        <label>22</label>
                        <mixed-citation publication-type="journal">P. Kora et al., “Transfer learning techniques for medical image analysis: A review,” Biocybern Biomed Eng, vol. 42, no. 1, pp. 79–107, Jan. 2022, doi: 10.1016/J.BBE.2021.11.004.</mixed-citation>
                    </ref>
                                    <ref id="ref23">
                        <label>23</label>
                        <mixed-citation publication-type="journal">M. Iman, H. R. Arabnia, and K. Rasheed, “A Review of Deep Transfer Learning and Recent Advancements,” Technologies 2023, Vol. 11, Page 40, vol. 11, no. 2, p. 40, Mar. 2023, doi: 10.3390/TECHNOLOGIES11020040.</mixed-citation>
                    </ref>
                                    <ref id="ref24">
                        <label>24</label>
                        <mixed-citation publication-type="journal">H. E. Kim, A. Cosa-Linan, N. Santhanam, M. Jannesari, M. E. Maros, and T. Ganslandt, “Transfer learning for medical image classification: a literature review,” BMC Medical Imaging 2022 22:1, vol. 22, no. 1, pp. 1–13, Apr. 2022, doi: 10.1186/S12880-022-00793-7.</mixed-citation>
                    </ref>
                                    <ref id="ref25">
                        <label>25</label>
                        <mixed-citation publication-type="journal">A. Krizhevsky, I. Sutskever, and G. E. Hinton, “ImageNet Classification with Deep Convolutional Neural Networks,” in Advances in Neural Information Processing Systems, F. Pereira, C. J. Burges, L. Bottou, and K. Q. Weinberger, Eds., Curran Associates, Inc., 2012.</mixed-citation>
                    </ref>
                                    <ref id="ref26">
                        <label>26</label>
                        <mixed-citation publication-type="journal">K. Simonyan and A. Zisserman, “Very Deep Convolutional Networks for Large-Scale Image Recognition,” 3rd International Conference on Learning Representations, ICLR 2015 - Conference Track Proceedings, Sep. 2014, Accessed: Sep. 06, 2024.</mixed-citation>
                    </ref>
                                    <ref id="ref27">
                        <label>27</label>
                        <mixed-citation publication-type="journal">C. Szegedy et al., “Going Deeper with Convolutions,” Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition, vol. 07-12-June-2015, pp. 1–9, Sep. 2014, doi: 10.1109/CVPR.2015.7298594.</mixed-citation>
                    </ref>
                                    <ref id="ref28">
                        <label>28</label>
                        <mixed-citation publication-type="journal">K. He, X. Zhang, S. Ren, and J. Sun, “Deep Residual Learning for Image Recognition,” Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition, vol. 2016-December, pp. 770–778, Dec. 2015, doi: 10.1109/CVPR.2016.90.</mixed-citation>
                    </ref>
                                    <ref id="ref29">
                        <label>29</label>
                        <mixed-citation publication-type="journal">“ImageNet,” https://www.image-net.org/.</mixed-citation>
                    </ref>
                            </ref-list>
                    </back>
    </article>
