saujs Sakarya University Journal of Science 2147-835X Sakarya University 10.16984/saufenbilder.1080420 Structural Biology Yapısal Biyoloji Investigation of Vitamins, Glutathione and Stress Biomarkers in Blood Serum of Patients with Breast Cancer https://orcid.org/0000-0002-4265-0453 Awla Ibraım Awat Hamad FIRAT ÜNİVERSİTESİ https://orcid.org/0000-0002-7225-8903 Özer Dursun FIRAT ÜNİVERSİTESİ https://orcid.org/0000-0002-0884-027X Karataş Fikret FIRAT ÜNİVERSİTESİ, FEN FAKÜLTESİ https://orcid.org/0000-0003-1531-5454 Saydam Sinan FIRAT ÜNİVERSİTESİ 04 30 2023 27 2 464 480 03 01 2022 01 17 2023 Copyright © 1997, Sakarya University Journal of Science 1997 Sakarya University Journal of Science

Breast cancer is a genetic disease caused by the accumulation of mutations in neoplastic cells and is responsible for the highest morbidity and mortality. In this study, blood serum samples from 45 breast cancer patients and 32 healthy individuals (control group) were used. The amounts of vitamins (A, E, β-carotene, C, B1, B2, B3, B5, B6, B9 and B12), glutathione (GSH, GSSG) stress biomarkers (4-HNE, MDA) were determined by HPLC. A significant difference was found between the breast cancer patients and the control group in terms of age and body mass index (BMI) (p

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