saujs Sakarya University Journal of Science 2147-835X Sakarya University 10.16984/saufenbilder.1137591 Chemical Engineering Kimya Mühendisliği Production and Characterization of Colon Targeted pH Sensitive Macrospheres and Investıgation of Release Kinetics https://orcid.org/0000-0002-1089-3741 Eren Belgin Ezgi MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ, FEN FAKÜLTESİ https://orcid.org/0000-0002-3199-3709 Delibalta Cankız Gizem MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ https://orcid.org/0000-0001-9719-6481 Çiçek Hüseyin MUĞLA SITKI KOÇMAN ÜNİVERSİTESİ 04 30 2023 27 2 408 418 06 29 2022 02 02 2023 Copyright © 1997, Sakarya University Journal of Science 1997 Sakarya University Journal of Science

The gastrointestinal track has different pH values at different sections. Thus, it is not easy to carry a drug to the colon for absorption. pH sensitive polymeric macrosphere drug carriers have important advantages such as being able to be taken orally, targeting the active ingredient to the desired area and dosing the active ingredient at the desired concentration for a long time in the target area. In this contex pH sensitive sodium alginate-gelatin macrospheres were produced by the dispersion phase gelling and cross-linking (complex coacervation) process method then loaded with Sternbergia lutea extract in this study. The macrosphere extract release kinetics were investigated for different pH medias that simulates different sections of the gastrointestinal track. As a result, the produced drug carrier macrospheres released the active ingredient at the colon pH (pH 7.0) while at lower pH values did not show a significant extract release. Therefore, it was reported that the produced macrospheres have potential to be used for colon diseases treatments.

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