saujs

Sakarya University Journal of Science

2147-835X

Sakarya University

10.16984/saufenbilder.989654

Spectrophotometric Determination of Losartan Potassium and Hydrochlorothiazide in tablets by Wavelet Transform Approach

https://orcid.org/0000-0001-9611-4210

Üstündağ

Özgür

ANKARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ

https://orcid.org/0000-0001-6326-1441

Dinç

Erdal

ANKARA ÜNİVERSİTESİ, ECZACILIK FAKÜLTESİ

12 31 2021

25 6 1432 1437 09 01 2021 11 16 2021

1997

Sakarya University Journal of Science

A precise, rapid and simple spectrophotometric method development with continuous wavelet transform technique was described in this paper for the simultaneous determination of losartan potassium and hydrochlorothiazide in tablets. The continuous wavelet transform approach based on the application of Symlets5-CWT. If the original UV spectra of losartan potassium and hydrochlorothiazide are examined, it is seen that the spectra of these two substances strongly overlap. With the developed Symlets5-CWT method, the analysis was carried out successfully without any pre-separation process. The calibration equations were obtained at 247.7 nm for the losartan potassium determination and at 259.1 nm for the hydrochlorothiazide determination, respectively. The developed methods were tested in terms of validity and applicability.

Spectrophotometry Continuous wavelet transform Losartan potassium Hydrochlorothiazide Quantitative determination

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