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Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi

Year 2021, Volume: 5 Issue: 1, 37 - 46, 24.12.2021

Abstract

Gastrointestinal sistemdeki bakteri türü ve konsantrasyonu fetal hayattan yaşlılığa kadar birçok etkenin etkisiyle değişime uğramaktadır. Kronik böbrek yetmezliği (KBY) görülen bireylerde artan üremi, metabolik asidoz, verilen diyet kısıtlamaları, uygulanan tıbbi tedavilerin etkisi, kolonik geçiş zamanının uzaması gibi birçok neden intestinal mikrobiyota florasında ve fonksiyonunda değişmelere neden olmaktadır. Bu değişiklikler kolonun mikrobiyal protein fermantasyonunu değiştirmekte ve üremik toksinlerin oluşumunu arttırmaktadır. Bu toksik maddeler intestinal lümendeki sıkı bağlantı (tight junction) proteinlerine zarar vermekte ve bağırsağın koruyucu epitelyal bariyerini bozmaktadır. Sonuçta bağırsak kaynaklı üremik toksinler sistemik dolaşıma geçmekte KBY progresyonuna, kardiyovasküler hastalıklara (KVH), insülin direncine, inflamasyona ve protein-enerji malnütrisyonuna katkıda bulunmaktadır.

References

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Year 2021, Volume: 5 Issue: 1, 37 - 46, 24.12.2021

Abstract

References

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  • 25. Vaziri ND, Yuan J, Rahimi A, Ni Z, Said H, Subramanian VS:Disintegration of colonic epithelial tight junction in uremia: A likely cause of CKD-associated inflammation. Nephrol Dial Transplant 2012;27:2686-2693
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  • 30. Vaziri ND, Goshtasbi N, Yuan J, Jellbauer S, Moradi H, Raffatellu M, et al.Uremic plasma impairs barrier function and depletes the tight junction protein constituents of intestinal epithelium. Am J Nephrol 2012;36:438-443
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  • 32. Shi K, Wang F, Jiang H, Liu H, Wei M, Wang Z, et al. Gut bacterial translocation may aggravate microinflammation in hemodialysis patients. Dig Dis Sci 2014;59:2109-2117
  • 33. Ritz E. Intestinal-renal syndrome: Mirage or reality? Blood Purif 2011;31:70-76
  • 34. Caesar, R., Tremaroli, V., Kovatcheva-Datchary, P., Cani, P. and Bäckhed, F. (2015). Crosstalk between gut microbiota and dietary lipids aggravates WAT inflammation through TLR signaling. Cell Metabolism, 22(4), 658-668.
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  • 36. Duncan, S., Belenguer, A., Holtrop, G., Johnstone, A., Flint, H. and Lobley, G. (2006). Reduced dietary intake of carbohydrates by obese subjects results in decreased concentrations of butyrate and butyrate-producing bacteria in feces. Applied and Environmental Microbiology, 73(4), 1073-1078.
  • 37. Kieffer DA, Martin RJ, Adams SH: Impact of dietary fibers on nutrient management and detoxification organs: Gut, liver, and kidneys. Adv Nutr 2016;7:1111-1121
  • 38. Zeng H, Chi H: Metabolic control of regulatory T cell development and function. Trends Immunol 2015;36:3-12
  • 39. Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 2013;341:569-573
  • 40. Evenepoel P, Poesen R, Meijers B: The gut-kidney axis. Pediatr Nephrol. 2016 Nov 15.
  • 41. Krishnamurthy VMR, Wei G, Baird BC, Murtaugh M, Chonchol MB, Raphael KL, Greene T, et al. High dietary fiber intake is associated with decreased inflammation and all-cause mortality in patients with chronic kidney disease. Kidney Int 2012;81:300-306,
  • 42. Chiavaroli L, Mirrahimi A, Sievenpiper JL, Jenkins DJ, Darlin PB: Dietary fiber effects in chronic kidney disease: A systematic review and meta-analysis of controlled feeding trials. Eur J Clin Nutr 2015;69:761-768
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  • 46. Healey, G., Murphy, R., Butts, C., Brough, L., Whelan, K., Coad, J. Habitual dietary fibre intake influences gut microbiota response to an inulin-type fructan prebiotic: a randomised, double-blind, placebo-controlled, cross-over, human intervention study. British Journal of Nutrition, 2018;119(2), 176-189.
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  • 48. Reddy, B. S., Weisburger, J. H. and Wynder, E. L. Efects of high risk and low risk diets for colon carcinogenesis on fecal microfora and steroids in man. Journal of Nutrition, 1975;105,878–884.
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There are 78 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Hacer Alataş 0000-0002-6441-0362

Mendane Saka 0000-0002-5516-426X

Publication Date December 24, 2021
Published in Issue Year 2021 Volume: 5 Issue: 1

Cite

APA Alataş, H., & Saka, M. (2021). Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. Sağlık Bilimleri Ve Yaşam Dergisi, 5(1), 37-46.
AMA Alataş H, Saka M. Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. SBYD. December 2021;5(1):37-46.
Chicago Alataş, Hacer, and Mendane Saka. “Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası Ve Endotoksemi”. Sağlık Bilimleri Ve Yaşam Dergisi 5, no. 1 (December 2021): 37-46.
EndNote Alataş H, Saka M (December 1, 2021) Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. Sağlık Bilimleri ve Yaşam Dergisi 5 1 37–46.
IEEE H. Alataş and M. Saka, “Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi”, SBYD, vol. 5, no. 1, pp. 37–46, 2021.
ISNAD Alataş, Hacer - Saka, Mendane. “Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası Ve Endotoksemi”. Sağlık Bilimleri ve Yaşam Dergisi 5/1 (December 2021), 37-46.
JAMA Alataş H, Saka M. Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. SBYD. 2021;5:37–46.
MLA Alataş, Hacer and Mendane Saka. “Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası Ve Endotoksemi”. Sağlık Bilimleri Ve Yaşam Dergisi, vol. 5, no. 1, 2021, pp. 37-46.
Vancouver Alataş H, Saka M. Kronik Böbrek Yetmezliğinde Bağırsak Mikrobiyotası ve Endotoksemi. SBYD. 2021;5(1):37-46.