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7β,19-diacetoxy-6α,8β-dihydroxy-4α,18-epoxy-neo-clerod-13-en15,16-olide, Isolated from Scutellaria orientalis L. subsp. porphyrostegia Edmondson

Year 2010, Volume: 5 Issue: 1, 75 - 80, 27.06.2010

Abstract

In this study, we aimed to obtain 7β,19-diasetoksi-6α,8β-dihidroksi-4α,18-epoksi-neo-klerod13-en-15,16-olide compound from Scutellaria orientalis L. subsp. Porphyrostegia Edmondson and to
designate of the chemical structure of compound. For this purpose, Scutellaria orientalis L. subsp. Porphyrostegia Edmondson plant’s acetone extract was prepared. The compound which obtained from this extract using chromatographic methods was purified and it’s structure was designated.

References

  • [1] Karabacak Ç., 2007. Bazı Scutellaria orientalis Türlerinin İçerisindeki Ekstraktif Bileşiklerin Araştırılması, Yüksek lisans tezi, Fen Bilimleri Enstitüsü, Süleyman Demirel Üniversitesi, Isparta, s. 106.
  • [2] Kubo M., Matsuda H., Tani T., Arichi S., Kimura Y., Okuda H., 1985. Studies on Scutellaria Radix. XII. Anti-Thrombic Actions of various Flavonoids from Scutellaria radix, Chemical Pharmaceutical Bulletin, 33 (6): 2411-2415.
  • [3] Zhang Y., Guo Y., Onda M., Hashimoto K., Ikeya Y., Okada M., Maruno M., 1994. Four Flavonoids from Scutellaria baicalensis, Phytochemistry, 35 (2): 511-514.
  • [4] Yung-Quı W., Matsuzaki K., Takahashi K., Okuyama T., Sahibata S., 1988. Studies of the Constitüents of Scutellaria species. I.The Flavonoid Glucuronides of "Bo Ye Huang Chin", Scutellaria ikonnikovii Juz., Chemical Pharmaceutical Bulletin, 36 (8): 3206-3209.
  • [5] Tomimori T., Imoto Y., Miyaichi Y., 1990. Studies of the Constitüents of Scutellaria species. XIII.On the Flavonoid Constitüents of the root of Scutellaria rivularis Wall, Chemical Pharmaceutical Bulletin, 38 (12): 3488-3490.
  • [6] Lin Y.L., Ou J.C., Chen C.F., Kuo Y.H., 1991. Flavonoids from the roots of Scutellaria luzonica Rolfe, Journal of the Chinese Chemical Society, 38: 619-623.
  • [7] Bae K.H., Min B.S., Park K.L., Ahn B.Z., 1994. Cytotoxic Flavonoids from Scutellaria indica, Planta Medica, 60: 280-281.
  • [8] Tomimori T., Miyaichi Y., Imoto Y., Kizu H., Namba T., 1985. Studies on the Nepalese Crude Drugs. V.On the Flavonoid Constitüents of the root of Scutellaria discolor Colebr.(1), Chemical Pharmaceutical Bulletin, 33 (10): 4457-4463.
  • [9] Miyaichi Y., Imoto Y., Tomimori T., Namba T., 1988. Studies on the Nepalese Crude Drugs. IX.On the Flavonoid Constitüents of the root of Scutellaria scandens Buch.-Ham.ex D.Don, Chemical Pharmaceutical Bulletin, 36 (7): 2371-2376.
  • [10] Miyaichi Y., Imoto Y., Tomimori T., Lin C.C., 1987. Studies on the Constitüents of Scutellaria species. IX. On the Flavonoid Constitüents of the root of Scutellaria indica L., Chemical Pharmaceutical Bulletin, 35 (9): 3720-3725.
  • [11] Bruno M., Rosselli S., Maggio A., Pıozzı F., Scaglioni L., Servettaz O., 2004. Scuteparvin, a new neoclerodane diterpenoid from Scutellaria parvula, Biochemical Systematics and Ecology, 32: 755-759.
  • [12] Çalış I., Ersöz T., Saraçoğlu I., Sticher O., 1993. Scalbidoside and Albidoside, Two Iridoid Glycosides from Scutellaria albida subsp. colchica, Phytochemistry, 32 (5): 1213-1217.
  • [13] Dai S., Tao J., Liu K., Jiang Y., Shen L., 2006. Neo-clerodane Diterpenoids from Scutellaria barbata with cytotoxic activities, Phytochemistry, 67: 1326-1330.
  • [14] Lin Y.L., Kuo Y.H., 1989. Four new neoclerodane-type diterpenoids, Scutellones B, G, H and I from aerial parts of Scutellaria rivularis, Chemical Pharmaceutical Bulletin, 37 (3): 582-585.

Scutellaria orientalis L. subsp. porphyrostegia Edmondson Bitkisinden 7β,19-diasetoksi-6α,8β-dihidroksi-4α,18-epoksi-neoklerod-13-en-15,16-olide Bileşiğinin İzole Edilmesi

Year 2010, Volume: 5 Issue: 1, 75 - 80, 27.06.2010

Abstract

Özet: Bu çalışmada, Scutellaria orientalis L. subsp. porphyrostegia Edmondson bitkisinden 7β,19-diasetoksi-6α,8β-dihidroksi-4α,18-epoksi-neo-klerod-13-en-15,16-olide bileşiğinin elde edilmesi ve bileşiğin kimyasal yapısının tayini amaçlanmıştır. Bu amaçla Scutellaria orientalis L. subsp. porphyrostegia Edmondson bitkisinin aseton ekstresi hazırlanmıştır. Bu ekstreden kromatografik yöntemler kullanılarak elde edilen bileşik saflaştırılmış ve yapısı tayin edilmiştir.

Anahtar kelimeler: Scutellaria, Labiatae, doğal ürün ekstraksiyonu, Diterpenoid

7β,19-diacetoxy-6α,8β-dihydroxy-4α,18-epoxy-neo-clerod-13-en-15,16-olide, Isolated from Scutellaria orientalis L. subsp.
porphyrostegia Edmondson

Abstract: In this study, we aimed to obtain 7β,19-diasetoksi-6α,8β-dihidroksi-4α,18-epoksi-neo-klerod-13-en-15,16-olide compound from Scutellaria orientalis L. subsp. Porphyrostegia Edmondson and to designate of the chemical structure of compound. For this purpose, Scutellaria orientalis L. subsp. Porphyrostegia Edmondson plant's acetone extract was prepared. The compound which obtained from this extract using chromatographic methods was purified and it's structure was designated.

Key words: Scutellaria, Labiatae, extraction of natural product, Diterpenoids

References

  • [1] Karabacak Ç., 2007. Bazı Scutellaria orientalis Türlerinin İçerisindeki Ekstraktif Bileşiklerin Araştırılması, Yüksek lisans tezi, Fen Bilimleri Enstitüsü, Süleyman Demirel Üniversitesi, Isparta, s. 106.
  • [2] Kubo M., Matsuda H., Tani T., Arichi S., Kimura Y., Okuda H., 1985. Studies on Scutellaria Radix. XII. Anti-Thrombic Actions of various Flavonoids from Scutellaria radix, Chemical Pharmaceutical Bulletin, 33 (6): 2411-2415.
  • [3] Zhang Y., Guo Y., Onda M., Hashimoto K., Ikeya Y., Okada M., Maruno M., 1994. Four Flavonoids from Scutellaria baicalensis, Phytochemistry, 35 (2): 511-514.
  • [4] Yung-Quı W., Matsuzaki K., Takahashi K., Okuyama T., Sahibata S., 1988. Studies of the Constitüents of Scutellaria species. I.The Flavonoid Glucuronides of "Bo Ye Huang Chin", Scutellaria ikonnikovii Juz., Chemical Pharmaceutical Bulletin, 36 (8): 3206-3209.
  • [5] Tomimori T., Imoto Y., Miyaichi Y., 1990. Studies of the Constitüents of Scutellaria species. XIII.On the Flavonoid Constitüents of the root of Scutellaria rivularis Wall, Chemical Pharmaceutical Bulletin, 38 (12): 3488-3490.
  • [6] Lin Y.L., Ou J.C., Chen C.F., Kuo Y.H., 1991. Flavonoids from the roots of Scutellaria luzonica Rolfe, Journal of the Chinese Chemical Society, 38: 619-623.
  • [7] Bae K.H., Min B.S., Park K.L., Ahn B.Z., 1994. Cytotoxic Flavonoids from Scutellaria indica, Planta Medica, 60: 280-281.
  • [8] Tomimori T., Miyaichi Y., Imoto Y., Kizu H., Namba T., 1985. Studies on the Nepalese Crude Drugs. V.On the Flavonoid Constitüents of the root of Scutellaria discolor Colebr.(1), Chemical Pharmaceutical Bulletin, 33 (10): 4457-4463.
  • [9] Miyaichi Y., Imoto Y., Tomimori T., Namba T., 1988. Studies on the Nepalese Crude Drugs. IX.On the Flavonoid Constitüents of the root of Scutellaria scandens Buch.-Ham.ex D.Don, Chemical Pharmaceutical Bulletin, 36 (7): 2371-2376.
  • [10] Miyaichi Y., Imoto Y., Tomimori T., Lin C.C., 1987. Studies on the Constitüents of Scutellaria species. IX. On the Flavonoid Constitüents of the root of Scutellaria indica L., Chemical Pharmaceutical Bulletin, 35 (9): 3720-3725.
  • [11] Bruno M., Rosselli S., Maggio A., Pıozzı F., Scaglioni L., Servettaz O., 2004. Scuteparvin, a new neoclerodane diterpenoid from Scutellaria parvula, Biochemical Systematics and Ecology, 32: 755-759.
  • [12] Çalış I., Ersöz T., Saraçoğlu I., Sticher O., 1993. Scalbidoside and Albidoside, Two Iridoid Glycosides from Scutellaria albida subsp. colchica, Phytochemistry, 32 (5): 1213-1217.
  • [13] Dai S., Tao J., Liu K., Jiang Y., Shen L., 2006. Neo-clerodane Diterpenoids from Scutellaria barbata with cytotoxic activities, Phytochemistry, 67: 1326-1330.
  • [14] Lin Y.L., Kuo Y.H., 1989. Four new neoclerodane-type diterpenoids, Scutellones B, G, H and I from aerial parts of Scutellaria rivularis, Chemical Pharmaceutical Bulletin, 37 (3): 582-585.
There are 14 citations in total.

Details

Primary Language Turkish
Subjects Structural Biology
Journal Section Makaleler
Authors

Çiğdem Karabacak This is me

Tahir Tilki This is me

Mustafa Cengiz

Publication Date June 27, 2010
Published in Issue Year 2010 Volume: 5 Issue: 1

Cite

IEEE Ç. Karabacak, T. Tilki, and M. Cengiz, “Scutellaria orientalis L. subsp. porphyrostegia Edmondson Bitkisinden 7β,19-diasetoksi-6α,8β-dihidroksi-4α,18-epoksi-neoklerod-13-en-15,16-olide Bileşiğinin İzole Edilmesi”, Süleyman Demirel University Faculty of Arts and Science Journal of Science, vol. 5, no. 1, pp. 75–80, 2010.