Fabrication of Polyvinylpyrrolidone Nanofibers with Green Solvents

Year 2019, Volume: 14 Issue: 2, 352 - 366, 30.11.2019

Funda Cengiz Çallıoğlu Hülya Kesici Güler

https://doi.org/10.29233/sdufeffd.589516

Cited By: 6

Abstract

In
this study, biocompatible Polyvinylpyrrolidone (PVP) nanofibers were produced with
ultra-pure water, rose water, lavender water, ethanol, acetone and acetic acid
with green electrospinning approach. Polymer solutions were characterized with
conductivity, surface tension and viscosity measurements. Morphological analyzes
were carried out with Scanning Electron Microscope (SEM). Conductivity, surface
tension and viscosity results of PVP/ ultra-pure water, rose water and lavender
water solutions were similar. On the other hand, PVP/acetic acid solution has
the highest viscosity and lowest conductivity values and PVP/ethanol solution
has got the lowest surface tension. In addition; the lowest average fiber
diameters were obtained from ultra-pure water, rose water and lavender water
solvents but there are some beads on the nanofiber structure. The smoothest
nanofibers without beads were obtained from PVP/ethanol but it was observed
that average fiber diameter is about 724 nm higher than other PVP solutions. Therefore,
ethanol was chosen as a co-solvent to enhance fiber morphology for second part
of study. Moreover; the relation between solution conductivity, nanofiber diameter
and web diameter were determined and it was found that nanofibrous surface
diameter increases and fiber diameter decreases with the increase of solution conductivity.

Keywords

Rose water, Lavender water, Green electrospinning, Polyvinylpyrrolidone, Green Solvent, Nanofiber

Thanks

The authors would like to thank Assoc. Prof. Dr. Sabri Erbaş and Dr. Gürcan GÜLER for their contributions.

Çevreci Çözücüler ile Polivinilpirolidon Nanolif Üretimi

Abstract

Bu çalışmada, çevreci
elektro lif çekimi yaklaşımı ile ultra saf su, gül suyu, lavanta suyu, etanol,
asetik asit ve aseton gibi farklı çevreci çözücüler ile biyouyumlu polivinilpirolidon
(PVP) nanoliflerin üretiminin gerçekleştirilmiştir. Polimer çözeltiler
iletkenlik, yüzey gerilimi ve viskozite ölçümleri ile karakterize edilmiştir.
Morfolojik analizler Taramalı Elektron Mikroskopu (SEM) ile
gerçekleştirilmiştir. PVP/ultra saf su, gül suyu ve lavanta suyu çözeltilerinin
iletkenlik, yüzey gerilimi ve viskozite sonuçları; benzer iken PVP/ asetik asit
çözeltisi en yüksek viskoziteye ve en düşük iletkenlik değerlerine sahiptir.
Diğer taraftan PVP/etanol çözeltisi en düşük yüzey gerilimine sahiptir. En
düşük ortalama lif çapı; ultra saf su, gül suyu ve lavanta suyu ile elde
edilmiştir fakat boncuklu lifler gözlenmiştir. En düzgün nanolifler PVP/etanol
çözeltisinden elde edilirken, ortalama lif çapının 724 nm civarında, diğer PVP
çözeltilerden daha kalın olduğu gözlenmiştir. Bu nedenle çalışmanın diğer kısmında
lif morfolojisini geliştirmek için etanol yardımcı çözücü olarak seçilmiştir. Ayrıca,
çözelti iletkenliği, lif çapı ve nanolifli yüzey çapı arasında ilişki olduğu
tespit edilmiş ve iletkenlik arttıkça, lif çapının azaldığı, nanolifli yüzey
çapının ise arttığı belirlenmiştir.

Keywords

Gül suyu, Lavanta suyu, Polivinilpirolidon, Çevreci çözücü, Çevreci elektro lif çekim yöntemi, Nanolif

References

• [1] D. A. Castilla-Casadiego, M. Maldonado, P. Sundaram, and J. Almodovar, “Green electrospinning of a collagen/hydroxyapatite composite nanofibrous scaffold,” MRS Commun., 6(4), 402-407, 2016.
• [2] V. V. T. Padil, S. Wacławek, and M. Černík, “Green synthesis: nanoparticles and nanofibres based on tree gums for environmental applications,” Ecol Chem Eng S, 23(4), 533-557, 2016.
• [3] T. Briggs, and T. L. Arinzeh, “Examining the formulation of emulsion electrospinning for improving the release of bioactive proteins from electrospun fiber,” J. Biomed. Mater. Res. A, 102 (3), 674-684, 2014.
• [4] D. Prat, J. Hayler and A. Wells, “A survey of solvent selection guides,” Green Chem., 16 (10), 4546–4551, 2014.
• [5] N. Bhardwaj, and S. C. Kundu, “Electrospinning: a fascinating fiber fabrication technique,” Biotechnol Adv., 28 (3), 325-347, 2010.
• [6] A. K. Haghi, Advances in Nanofibre Research. Shawbury, Shrewsbury, Shropshire: Smithers Rapra, 2011.
• [7] J.-H. He, Y. Liu, L.-F. Mo, Y.-Q. Wan, and L. Xu, “Electrospun nanofibres and their applications,” Shawbury, Shrewsbury, Shropshire: Ismithers Shawbury, 2008.
• [8] R. Salehi, M. Irani, M. Eskandani, K. Nowruzi, S. Davaran, and I. Haririan, “Interaction, controlled release, and antitumor activity of doxorubicin hydrochloride from pH-sensitive P (NIPAAm-MAA-VP) nanofibrous scaffolds prepared by green electrospinning,” Int. J. Polym. Mater. Po., 63 (12), 609-619, 2014.
• [9] R. Sridhar, S. Sundarrajan, A. Vanangamudi, G. Singh, T. Matsuura, and S. Ramakrishna, “Green processing mediated novel polyelectrolyte nanofibers and their antimicrobial evaluation,” Macromol. Mater. Eng., 299 (3), 283-289, 2014.
• [10] X. Yang, L. Fan, L. Ma, Y. Wang, S. Lin, F. Yu, X. Pan, G. Luo, D. Zhang, and H. Wang, “Green electrospun Manuka honey/silk fibroin fibrous matrices as potential wound dressing,” Mater. Des., 119, 76-84, 2017.
• [11] T. Uyar, and F. Besenbacher, “Electrospinning of uniform polystyrene fibers: The effect of solvent conductivity,” Polymer, 49 (24), 5336-5343, 2008.
• [12] A. Çay, E. P. Akçakoca Kumbasar, and Ç. Akduman, “Effects of Solvent Mixtures on The Morphology of Electrospun Thermoplastic Polyurethane Nanofibres,” Journal of Textile & Apparel, 25(1), 38-46, 2015.
• [13] R. Casasola, N. L. Thomas, A. Trybala, and S. Georgiadou, “Electrospun poly lactic acid (PLA) fibres: effect of different solvent systems on fibre morphology and diameter,” Polymer, 55 (18), 4728-4737, 2014.
• [14] B. Veleirinho, M. F. Rei, and J. Lopes‐Da‐Silva, “Solvent and concentration effects on the properties of electrospun poly (ethylene terephthalate) nanofiber mats,” J. Polym. Sci. B. Polym. Phys., 46 (5), 460-471, 2008.
• [15] L. Burke, C. J. Mortimer, D. J. Curtis, A. R. Lewis, R. Williams, K. Hawkins, T. G. G. Maffeis, C. J. Wright, “In-situ synthesis of magnetic iron-oxide nanoparticle-nanofibre composites using electrospinning,” Mater. Sci. Eng. C, 70, 512-519, 2017.
• [16] D. Han, M. Sasaki, H. Yoshino, S. Kofuji, A. T. Sasaki, and A. J. Steckl, “In-vitro evaluation of MPA-loaded electrospun coaxial fiber membranes for local treatment of glioblastoma tumor cells,” J. Drug Deliv. Sci. Tec., 40, 45-50, 2017.
• [17] R. Gharib, A. Najjar, L. Auezova, C. Charcosset, and H. Greige-Gerges, “Interaction of selected phenylpropenes with dipalmitoylphosphatidylcholine membrane and their relevance to antibacterial activity,” J. Membr. Biol., 250 (3), 259-271, 2017.
• [18] Y.-N. Jiang, H.-Y. Mo, and D.-G. Yu, “Electrospun drug-loaded core–sheath PVP/zein nanofibers for biphasic drug release,” Int. J. Pharm., 438 (1-2), 232-239, 2012.
• [19] B. Wang, M. Wang, M.-W. Chang, Z. Ahmad, J. Huang, and J.-S. Li, “Non-concentric multi-compartment fibers fabricated using a modified nozzle in single-step electrospinning,” Mater. Lett., 202, 134-137, 2017.
• [20] L. Wang, M.-W. Chang, Z. Ahmad, H. Zheng, and J.-S. Li, “Mass and controlled fabrication of aligned PVP fibers for matrix type antibiotic drug delivery systems,” Chem. Eng. J., 307, 661-669, 2017.
• [21] D.-G. Yu, X.-X. Shen, C. Branford-White, K. White, L.-M. Zhu, and S. A. Bligh, “Oral fast-dissolving drug delivery membranes prepared from electrospun polyvinylpyrrolidone ultrafine fibers,” Nanotechnology, 20 (5), 055104, 2009.
• [22] D. Yu, X. Wang, X. Li, W. Chian, Y. Li, and Y. Liao, “Electrospun biphasic drug release polyvinylpyrrolidone/ethyl cellulose core/sheath nanofibers,” Acta Biomater., 9 (3), 5665-5672, 2013.
• [23] N. N. Maslakci, S. Ulusoy, E. Uygun, H. Çevikbaş, L. Oksuz, H. K. Can, and A. U. Oksuz, “Ibuprofen and acetylsalicylic acid loaded electrospun PVP-dextran nanofiber mats for biomedical applications,” Polym. Bull., 74 (8), 3283-3299, 2017.
• [24] S. Torres-Giner, S. Wilkanowicz, B. Melendez-Rodriguez, and J. M. Lagaron, “Nanoencapsulation of Aloe vera in synthetic and naturally occurring polymers by electrohydrodynamic processing of interest in food technology and bioactive packaging,” J. Agric. Food. Chem., 65 (22), 4439-4448, 2017.
• [25] S. Chuangchote, T. Sagawa, and S. Yoshikawa, “Electrospinning of poly (vinyl pyrrolidone): Effects of solvents on electrospinnability for the fabrication of poly (p‐phenylene vinylene) and TiO2 nanofibers,” J. Appl. Polym. Sci., 114 (5), 2777-2791, 2009.
• [26] Q. Yang, Z. Li, Y. Hong, Y. Zhao, S. Qiu, C. Wang, and Y. Wei, “Influence of solvents on the formation of ultrathin uniform poly (vinyl pyrrolidone) nanofibers with electrospinning,” J. Polym. Sci. B Polym. Phys., 42 (20), 3721-3726, 2004.
• [27] M. H. Boskabady, M. N. Shafei, Z. Saberi, and S. Amini, “Pharmacological effects of Rosa damascena,” Iran J. Basic Med. Sci., 14 (4), 295-307, 2011.
• [28] H. Kesici Güler, F. Cengiz Çallıoğlu, and E. Sesli Çetin, “Antibacterial PVP/cinnamon essential oil nanofibers by emulsion electrospinning,” J. Text. I., 110 (2), 302-310, 2019.
• [29] F. Cengiz, and O. Jirsak, “The effect of salt on the roller electrospinning of polyurethane nanofibers,” Fiber Polym., 10 (2), 177-184, 2009.
• [30] A. Haider, S. Haider, and I.-K. Kang, “A comprehensive review summarizing the effect of electrospinning parameters and potential applications of nanofibers in biomedical and biotechnology,” Arab. J. Chem., 11 (8), 1165-1188, 2015.
• [31] S. Tan, R. Inai, M. Kotaki, and S. Ramakrishna, “Systematic parameter study for ultra-fine fiber fabrication via electrospinning process,” Polymer, 46 (16), 6128-6134, 2005.
• [32] S. Ramakrishna, K. Fujihara, W. Teo, T. Lim, and Z. Ma, “An Introduction to Electrospinning and Nanofibers,” London: World Scientific, 2005.